Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina

Current Eye Research

Volumn 21, Issue 1, 2000, Pages 571-580

  Sakamoto, Y ^a   Nakajima, T ^a   Fukiage, C ^a   Sakai, O ^a   Yoshida, Y ^a   Azuma, M ^a   Shearer, T R ^a  

^a SENJU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Calpain; Calpain inhibitor SJA6017; Ischemia reperfusion; Rat; Retina

Indexed keywords

CALCIUM; CALPAIN; CALPASTATIN; FODRIN; ISOENZYME; M CALPAIN; MU CALPAIN; N (FLUOROPHENYLSULFONYL)VALYLLEUCINAL; PENTOBARBITAL; SJA 6017; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; REPERFUSION; REPERFUSION INJURY; RETINA ARTERY OCCLUSION; RETINA BLOOD FLOW; RETINA CELL; RETINA INJURY; RETINA INNER PLEXIFORM LAYER; RETINA ISCHEMIA; RETINA NERVE CELL;

EID: 0033749658     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/0271-3683(200007)2111-ZFT571     Document Type: Article

References (32)

1. Calpain: A cytosolic proteinase active at the membranes
2. Calpain: A protease in search of a function?
3. Structure and physiological function of calpains
4. Calpain: New perspectives in molecular diversity and physiological-pathological involvement
5. Identification of a retina-specific calpain from rat
6. Positive regulation of μ-calpain action by polyphos-phoinositides
7. Spatial resolution of fodrin proteolysis in postischemic brain
8. Three distinct phases of fodrin proteolysis induced in postischemic hippocampus
9. Prolonged calpain-mediated spectrin break-down occurs regionally following experimental brain injury in the rat
10. Selective neuronal cell death induced by activation of μ-calpain under conditions of ischemia/reperfusion
11. Temporal ordering of pathogenic events following transient global ischemia
12. Dual response of calpain to rat brain postdecapitative ischemia
13. Postischemic reperfusion induces α-fodrin proteolysis by m-calpain in the synaptosome and nucleus in rat brain
14. Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia
15. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
16. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat
17. High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats
18. Irregular retinal and RPE damage after pressure-induced ischemia in the rabbit
19. Necrosis and apoptosis after retinal ischemia: Involvement of NMDA-mediated excitotoxicity and p53
20. Expression of cell cycle-related genes in dying cells in retinal ischemic injury
21. Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family protease
22. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: Amelioration of cataract in cultured rat lenses
23. Activation of calpain in lens: A review and proposed mechanism
24. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
25. Calpain in excitotoxicity, cerebral ischemia, and neuronal apoptosis
26. Possible mechanism for the decrease of mitochondrial aspartate aminotransferase activity in ischemic and hypoxic rat retinas
27. Decreased sensitivity of lens-specific calpain Lp82 to calpastatin inhibitor
28. Immunohistochemical localization of calpains and calpastatin in the rabbit eye
29. Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia
30. Ischemic Cell death in brain neurons
31. Effect of calpain on the composition and structure of postsynaptic densities
32. The novel calpain inhibitor SJA6017 improves functional recovery after delayed administration in a mouse model of diffuse head injury