Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON)

Neurobiology of Disease

Volumn 24, Issue 2, 2006, Pages 308-317

  Beretta, Simone ^a   Wood, John P M ^b   Derham, Barry ^c   Sala, Gessica ^a   Tremolizzo, Lucio ^a   Ferrarese, Carlo ^a   Osborne, Neville N ^b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Complex I; Excitotoxicity; GLAST; Leber hereditary optic neuropathy (LHON); Reactive oxygen species; Retina; Rotenone

Indexed keywords

FREE RADICAL; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; OXIDOREDUCTASE; ROTENONE; SODIUM;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITION; EXPOSURE; GLIA CELL; LEBER HEREDITARY OPTIC NEUROPATHY; LIPID PEROXIDATION; MUELLER CELL; NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA CELL; SENSITIVITY ANALYSIS; TOXICITY; TRANSPORT KINETICS;

ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; ENERGY METABOLISM; EXCITATORY AMINO ACID TRANSPORTER 1; FREE RADICALS; GLUTAMIC ACID; LIPID PEROXIDATION; MITOCHONDRIA; NEUROGLIA; NEURONS; OPTIC ATROPHY, HEREDITARY, LEBER; OXIDATIVE STRESS; RATS; RATS, WISTAR; RETINA; RETINAL GANGLION CELLS; ROTENONE; UNCOUPLING AGENTS;

EID: 33749986488     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.07.016     Document Type: Article

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