Mapping antiretroviral drugs in tissue by IR-MALDESI MSI coupled to the Q Exactive and comparison with LC-MS/MS SRM assay

Journal of the American Society for Mass Spectrometry

Volumn 25, Issue 12, 2014, Pages 2038-2047

  Barry, Jeremy A ^a   Robichaud, Guillaume ^a   Bokhart, Mark T ^a   Thompson, Corbin ^b   Sykes, Craig ^b   Kashuba, Angela D M ^b   Muddiman, David C ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

Drug distribution; IR MALDESI; LC MS MS; Mass spectrometry imaging

Indexed keywords

EMTRICITABINE; RALTEGRAVIR; TENOFOVIR; 2 PYRROLIDONE DERIVATIVE; ADENINE; ANTIRETROVIRUS AGENT; DEOXYCYTIDINE; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG UPTAKE; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MATRIX ASSISTED LASER DESORPTION ELECTROSPRAY IONIZATION MASS SPECTROMETRY IMAGING; TANDEM MASS SPECTROMETRY; TISSUE SECTION; UTERINE CERVIX; ANALOGS AND DERIVATIVES; CHEMISTRY; CYTOCHEMISTRY; FEMALE; MASS SPECTROMETRY; METABOLISM; MOLECULAR IMAGING; PROCEDURES; TISSUE DISTRIBUTION;

ADENINE; ANTI-RETROVIRAL AGENTS; CERVIX UTERI; CHROMATOGRAPHY, LIQUID; DEOXYCYTIDINE; EMTRICITABINE; FEMALE; HISTOCYTOCHEMISTRY; HUMANS; MOLECULAR IMAGING; ORGANOPHOSPHONATES; PYRROLIDINONES; RALTEGRAVIR POTASSIUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY; TENOFOVIR; TISSUE DISTRIBUTION;

EID: 84908011789     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-014-0884-1     Document Type: Article

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