In Situ Mass Spectrometry Imaging and Ex Vivo Characterization of Renal Crystalline Deposits Induced in Multiple Preclinical Drug Toxicology Studies

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Nilsson, Anna ^a   Forngren, Benita ^b   Bjurström, Sivert ^b   Goodwin, Richard J A ^b   Basmaci, Elisa ^b   Gustafsson, Ingela ^b   Annas, Anita ^b   Hellgren, Dennis ^b   Svanhagen, Alexander ^b   Andrén, Per E ^a   Lindberg, Johan ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 (CYCLOBUTYLETHYNYL) N [(2 SULFAMOYLPHENYL)SULFONYL]BENZAMIDE; 4 (PHENYLETHYNYL) N [(2 SULFAMOYLPHENYL)SULFONYL]BENZAMIDE; BENZAMIDE DERIVATIVE; PROSTAGLANDIN E SYNTHASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG STRUCTURE; EX VIVO STUDY; FEMALE; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE QUALITY; KIDNEY INJURY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; TOXICITY TESTING;

ANIMALS; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; FEMALE; INTRAMOLECULAR OXIDOREDUCTASES; KIDNEY; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RATS; TOXICOLOGY;

EID: 84867886333     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047353     Document Type: Article

References (28)

1. Goodsaid FM, Blank M, Dieterle F, Harlow P, Hausner E, et al. (2009) Novel biomarkers of acute kidney toxicity. Clin Pharmacol Ther 86: 490-496.
2. Kuhlmann J, Wensing G, (2006) The applications of biomarkers in early clinical drug development to improve decision-making processes. Curr Clin Pharmacol 1: 185-191.
3. Pellegatti M, Pagliarusco S, (2011) Drug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review. Expert Opin Drug Metab Toxicol 7: 137-146.
4. Monro AM, (1990) Interspecies comparisons in toxicology: the utility and futility of plasma concentrations of the test substance. Regul Toxicol Pharmacol 12: 137-160.
5. Dieterle F, Marrer E, Suzuki E, Grenet O, Cordier A, et al. (2008) Monitoring kidney safety in drug development: emerging technologies and their implications. Curr Opin Drug Discov Devel 11: 60-71.
6. Izzedine H, Launay-Vacher V, Deray G, (2005) Antiviral drug-induced nephrotoxicity. Am J Kidney Dis 45: 804-817.
7. Clarke CJ, Haselden JN, (2008) Metabolic profiling as a tool for understanding mechanisms of toxicity. Toxicol Pathol 36: 140-147.
8. Drexler DM, Reily MD, Shipkova PA, (2011) Advances in mass spectrometry applied to pharmaceutical metabolomics. Anal Bioanal Chem 399: 2645-2653.
9. Guillarme DS, Julie; Rudaz, Serge; Veuthey, (2010) Jean-Luc (2010) Coupling ultra-high-pressure liquid chromatography with mass spectrometry. Trends in Analytical Chemistry 29: 15-27.
10. Emmert-Buck MR, Bonner RF, Smith PD, Chuaqui RF, Zhuang Z, et al. (1996) Laser capture microdissection. Science 274: 998-1001.
11. Goodwin RJ, Scullion P, Macintyre L, Watson DG, Pitt AR, (2010) Use of a solvent-free dry matrix coating for quantitative matrix-assisted laser desorption ionization imaging of 4-bromophenyl-1,4-diazabicyclo(3.2.2)nonane-4-carboxylate in rat brain and quantitative analysis of the drug from laser microdissected tissue regions. Anal Chem 82: 3868-3873.
12. Mustafa D, Kros JM, Luider T, (2008) Combining laser capture microdissection and proteomics techniques. Methods Mol Biol 428: 159-178.
13. Beckonert O, Coen M, Keun HC, Wang Y, Ebbels TM, et al. (2010) High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues. Nat Protoc 5: 1019-1032.
14. Cazares LH, Troyer DA, Wang B, Drake RR, Semmes OJ, (2011) MALDI tissue imaging: from biomarker discovery to clinical applications. Anal Bioanal Chem 401: 17-27.
15. Seeley EH, Schwamborn K, Caprioli RM, (2011) Imaging of intact tissue sections: moving beyond the microscope. J Biol Chem 286: 25459-25466.
16. Solon EG, Schweitzer A, Stoeckli M, Prideaux B, (2010) Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. Aaps J 12: 11-26.
17. Caprioli RM, Farmer TB, Gile J, (1997) Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal Chem 69: 4751-4760.
18. Fernandez JA, Ochoa B, Fresnedo O, Giralt MT, Rodriguez-Puertas R, (2011) Matrix-assisted laser desorption ionization imaging mass spectrometry in lipidomics. Anal Bioanal Chem 401: 29-51.
19. Goodwin RJ, Mackay CL, Nilsson A, Harrison DJ, Farde L, et al. (2011) Qualitative and Quantitative MALDI Imaging of the Positron Emission Tomography Ligands Raclopride (a D2 Dopamine Antagonist) and SCH 23390 (a D1 Dopamine Antagonist) in Rat Brain Tissue Sections Using a Solvent-Free Dry Matrix Application Method. Anal Chem 83: 9694-9701.
20. Khatib-Shahidi S, Andersson M, Herman JL, Gillespie TA, Caprioli RM, (2006) Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal Chem 78: 6448-6456.
21. Nilsson A, Fehniger TE, Gustavsson L, Andersson M, Kenne K, et al. (2010) Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry. PLoS One 5: e11411.
22. Stoeckli M, Chaurand P, Hallahan DE, Caprioli RM, (2001) Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat Med 7: 493-496.
23. Goodwin RJ, Pitt AR, (2010) Mass spectrometry imaging of pharmacological compounds in tissue sections. Bioanalysis 2: 279-293.
24. Prideaux B, Staab D, Stoeckli M, (2010) Applications of MALDI-MSI to pharmaceutical research. Methods Mol Biol 656: 405-413.
25. Sugiura Y, Setou M, (2010) Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes. J Neuroimmune Pharmacol 5: 31-43.
26. Drexler DM, Garrett TJ, Cantone JL, Diters RW, Mitroka JG, et al. (2007) Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues. J Pharmacol Toxicol Methods 55: 279-288.
27. Aberg KM, Torgrip RJ, Kolmert J, Schuppe-Koistinen I, Lindberg J, (2008) Feature detection and alignment of hyphenated chromatographic-mass spectrometric data. Extraction of pure ion chromatograms using Kalman tracking. J Chromatogr A 1192: 139-146.
28. Perazella MA, (1999) Crystal-induced acute renal failure. Am J Med 106: 459-465.