Mass spectrometry imaging with high resolution in mass and space (HR 2 MSI) for reliable investigation of drug compound distributions on the cellular level

Analytical and Bioanalytical Chemistry

Volumn 401, Issue 1, 2011, Pages 65-73

  Römpp, Andreas ^a   Guenther, Sabine ^a   Takats, Zoltan ^a   Spengler, Bernhard ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Accurate mass; Drug compounds; High resolution mass spectrometry; Mass spectrometry imaging

Indexed keywords

ACCURATE MASS; ANALYTES; ANTICANCER DRUG; BIN SIZE; CELLULAR LEVELS; DRUG COMPOUNDS; HIGH RESOLUTION; HIGH RESOLUTION MASS SPECTROMETRY; HIGH SPATIAL RESOLUTION; HISTOLOGICAL FEATURES; IFOSFAMIDE; IMAGING METHOD; IMATINIB; INTESTINAL TRACT; ION IMAGES; LABEL-FREE DETECTION; MASS RESOLUTION; MASS SPECTRA; MOUSE KIDNEY; PHARMACOKINETIC STUDIES; ROOT MEAN SQUARE; SPATIAL RESOLUTION; SPECIFIC INFORMATION; STEP SIZE; TISSUE SECTIONS; UNIQUE FEATURES; VERSATILE METHODS; WHOLE-BODY;

IMAGE RESOLUTION; MAMMALS; MASS SPECTROMETRY; PHOSPHOLIPIDS; PORPHYRINS; SPATIAL DISTRIBUTION; TISSUE;

SPATIAL VARIABLES MEASUREMENT;

ANTINEOPLASTIC AGENT; IFOSFAMIDE; IMATINIB; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; DIAGNOSTIC IMAGING; EVALUATION; GASTROINTESTINAL TRACT; KIDNEY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE; NUDE MOUSE; RAT; SENSITIVITY AND SPECIFICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; DIAGNOSTIC IMAGING; GASTROINTESTINAL TRACT; IFOSFAMIDE; KIDNEY; MICE; MICE, NUDE; PIPERAZINES; PYRIMIDINES; RATS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ANIMALIA; RATTUS;

EID: 79960559981     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-4990-7     Document Type: Article

References (28)

1. K Chughtai RMA Heeren 2010 Mass spectrometric imaging for biomedical tissue analysis Chem Rev 110 5 3237 3277 10.1021/cr100012c 1:CAS:528: DC%2BC3cXltlWisLk%3D
2. LA McDonnell RMA Heeren 2007 Imaging mass spectrometry Mass Spectrom Rev 26 4 606 643 10.1002/mas.20124 10.1002/mas.20124 1:CAS:528:DC%2BD2sXot1KltLk%3D (Pubitemid 47169781)
3. B Spengler M Hubert 2002 Scanning microprobe matrix-assisted laser desorption ionization (SMALDI) mass spectrometry: instrumentation for sub-micrometer resolved LDI and MALDI surface analysis J Am Soc Mass Spectrom 13 6 735 748 10.1016/S1044-0305(02)00376-8 1:CAS:528:DC%2BD38Xjsl2lu7o%3D (Pubitemid 36876027)
4. Spengler B, Hubert M, Kaufmann R (1994) MALDI ion imaging and biological ion imaging with a new scanning UV-laser microprobe. In: Proceedings of the 42nd Annual Conference on Mass Spectrometry and Allied Topics, Chicago, Illinois, 29 May-3 June, p 1041
5. M Stoeckli P Chaurand DE Hallahan RM Caprioli 2001 Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues Nat Med 7 4 493 496 10.1038/86573 1:CAS:528: DC%2BD3MXis1yksLo%3D (Pubitemid 32298555)
6. SN Jackson HYJ Wang AS Woods 2005 In situ structural characterization of phosphatidylcholines in brain tissue using MALDI-MS/MS J Am Soc Mass Spectrom 16 12 2052 2056 10.1016/j.jasms.2005.08.014 10.1016/j.jasms.2005.08.014 1:CAS:528:DC%2BD2MXht1CmsbrO (Pubitemid 41642968)
7. RB Chen XY Jiang MCP Conaway I Mohtashemi LM Hui R Viner LJ Li 2010 Mass spectral analysis of neuropeptide expression and distribution in the nervous system of the lobster Homarus americanus J Proteome Res 9 2 818 832 10.1021/pr900736t 10.1021/pr900736t 1:CAS:528:DC%2BC3cXnsVylug%3D%3D
8. M Stoeckli D Staab M Staufenbiel KH Wiederhold L Signor 2002 Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry Anal Biochem 311 1 33 39 10.1016/S0003-2697(02)00386-X 1:CAS:528: DC%2BD38Xos1GntLY%3D (Pubitemid 35463486)
9. ML Reyzer RM Caprioli 2007 MALDI-MS-based imaging of small molecules and proteins in tissues Curr Opin Chem Biol 11 1 29 35 10.1016/j.cbpa.2006.11.035 10.1016/j.cbpa.2006.11.035 1:CAS:528:DC%2BD2sXhsFOhs7s%3D (Pubitemid 46217921)
10. ML Reyzer YS Hsieh K Ng WA Korfmacher RM Caprioli 2003 Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry J Mass Spectrom 38 10 1081 1092 10.1002/jms.525 10.1002/jms.525 1:CAS:528:DC%2BD3sXovFCltb4%3D (Pubitemid 37407703)
11. M Stoeckli D Staab A Schweitzer 2007 Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections Int J Mass Spectrom 260 2-3 195 202 10.1016/j.ijms.2006.10.007 1:CAS:528: DC%2BD2sXitFSitQ%3D%3D
12. EG Solon A Schweitzer M Stoeckli B Prideaux 2010 Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development AAPS J 12 1 11 26 10.1208/s12248-009-9158-4 10.1208/s12248-009-9158-4 1:CAS:528:DC%2BC3cXisVGrtr0%3D
13. S Khatib-Shahidi M Andersson JL Herman TA Gillespie RM Caprioli 2006 Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry Anal Chem 78 18 6448 6456 10.1021/ac060788p 10.1021/ac060788p 1:CAS:528:DC%2BD28XnsF2iurg%3D (Pubitemid 44418954)
14. DS Cornett SL Frappier RM Caprioli 2008 MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue Anal Chem 80 14 5648 5653 10.1021/ac800617s 10.1021/ac800617s 1:CAS:528:DC%2BD1cXnsVehtL4%3D
15. E Acquadro C Cabella S Ghiani L Miragoli EM Bucci D Corpillo 2009 Matrix-assisted laser desorption ionization imaging mass spectrometry detection of a magnetic resonance imaging contrast agent in mouse liver Anal Chem 81 7 2779 2784 10.1021/ac900038y 10.1021/ac900038y 1:CAS:528:DC%2BD1MXivF2qsbk%3D
16. PJ Trim CM Henson JL Avery A McEwen MF Snel E Claude PS Marshall A West AP Princivalle MR Clench 2008 Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of Vinblastine in whole body tissue sections Anal Chem 80 22 8628 8634 10.1021/ac8015467 10.1021/ac8015467 1:CAS:528:DC%2BD1cXht1ehsb%2FL
17. G Hopfgartner E Varesio M Stoeckli 2009 Matrix-assisted laser desorption/ionization mass spectrometric imaging of complete rat sections using a triple quadrupole linear ion trap Rapid Commun Mass Spectrom 23 6 733 736 10.1002/rcm.3934 10.1002/rcm.3934 1:CAS:528:DC%2BD1MXjt1Wgu7Y%3D
18. DM Drexler TJ Garrett JL Cantone RW Diters JG Mitroka MC Prieto Conaway SP Adams RA Yost M Sanders 2007 Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues J Pharmacol Toxicol Meth 55 3 279 288 10.1016/j.vascn.2006.11.004 10.1016/j.vascn.2006.11.004 1:CAS:528:DC%2BD2sXjsVGgsr4%3D (Pubitemid 46436524)
19. AG Marshall CL Hendrickson 2002 Fourier transform ion cyclotron resonance detection: principles and experimental configurations Int J Mass Spectrom 215 1-3 59 75 1:CAS:528:DC%2BD38XisV2rt74%3D
20. A Römpp IM Taban R Mihalca MC Duursma TH Mize LA McDonnell RMA Heeren 2005 Examples of Fourier transform ion cyclotron resonance mass spectrometry developments: from ion physics to remote access biochemical mass spectrometry Eur J Mass Spectrom 11 5 443 456 10.1255/ejms.732 (Pubitemid 41796532)
21. M Scigelova A Makarov 2006 Orbitrap mass analyzer-overview and applications in proteomics Proteomics 6 1 16 21 10.1002/pmic.200600528 10.1002/pmic.200600528 (Pubitemid 44625764)
22. RR Landgraf MCP Conaway TJ Garrett PW Stacpoole RA Yost 2009 Imaging of lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS Anal Chem 81 20 8488 8495 10.1021/ac901387u 10.1021/ac901387u 1:CAS:528:DC%2BD1MXhtFantLvL
23. A Römpp S Guenther Y Schober O Schulz Z Takats W Kummer B Spengler 2010 Histology by mass spectrometry: label-free tissue characterization obtained from high-accuracy bioanalytical imaging Angew Chem Int Ed 49 22 3834 3838 10.1002/anie.200905559
24. S Guenther A Römpp W Kummer B Spengler 2011 AP-MALDI imaging of neuropeptides in mouse pituitary gland with 5 μm spatial resolution and high mass accuracy Int J Mass Spectrom 10.1016/j.ijms.2010.11.011
25. W Bouschen O Schulz D Eikel B Spengler 2010 Matrix vapor deposition/recrystallization and dedicated spray preparation for high-resolution scanning microprobe matrix-assisted laser desorption/ionization imaging mass spectrometry (SMALDI-MS) of tissue and single cells Rapid Commun Mass Spectrom 24 3 355 364 10.1002/rcm.4401 1:CAS:528:DC%2BC3cXlvVWmsg%3D%3D
26. M Koestler D Kirsch A Hester A Leisner S Guenther B Spengler 2008 A high-resolution scanning microprobe matrix-assisted laser desorption/ionization ion source for imaging analysis on an ion trap/Fourier transform ion cyclotron resonance mass spectrometer Rapid Commun Mass Spectrom 22 20 3275 3285 10.1002/rcm.3733 10.1002/rcm.3733 1:CAS:528:DC%2BD1cXhtleiu73K
27. S Guenther M Koestler O Schulz B Spengler 2010 Laser spot size and laser power dependence of ion formation in high resolution MALDI imaging Int J Mass Spectrom 294 1 7 15 10.1016/j.ijms.2010.03.014 10.1016/j.ijms.2010.03.014 1:CAS:528:DC%2BC3cXntlCqsLo%3D
28. EJ Weinman J Lakkis M Akom RK Wali CB Drachenberg RA Coleman JB Wade 2002 Expression of NHERF-1, NHERF-2, PDGFR-alpha, and PDGFR-beta in normal human kidneys and in renal transplant rejection Pathobiology 70 6 314 323 10.1159/000071271 10.1159/000071271 (Pubitemid 36829006)