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Volumn 27, Issue 9, 2013, Pages 1413-1419

Differential penetration of raltegravir throughout gastrointestinal tissue: Implications for eradication and cure

Author keywords

Gut associated lymphoid tissue; HIV cure; Latency; Pharmacokinetics; Raltegravir

Indexed keywords

RALTEGRAVIR;

EID: 84879084001     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835f2b49     Document Type: Article
Times cited : (52)

References (45)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998; 338:853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5    Satten, G.A.6
  • 3
    • 47649115323 scopus 로고    scopus 로고
    • Life expectancy of individuals on combination antiretroviral therapy in high-income countries: A collaborative analysis of 14 cohort studies
    • The Antiretroviral Therapy Cohort Collaboration
    • Hogg R, Lima V, Sterne JA, Grabar S, Bonarek M, The Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 2008; 372:293-299.
    • (2008) Lancet , vol.372 , pp. 293-299
    • Hogg, R.1    Lima, V.2    Sterne, J.A.3    Grabar, S.4    Bonarek, M.5
  • 4
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278:1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3    Carruth, L.M.4    Buck, C.5    Chaisson, R.E.6
  • 5
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong JK, Hezareh M, Gunthard HF, Havlir DV, Ignacio CC, Spina CA, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997; 278: 1291-1295.
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1    Hezareh, M.2    Gunthard, H.F.3    Havlir, D.V.4    Ignacio, C.C.5    Spina, C.A.6
  • 6
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD4(R) T cells during primary HIV-1 infection
    • Chun TW, Engel D, Berrey MM, Shea T, Corey L, Fauci AS. Early establishment of a pool of latently infected, resting CD4(R) T cells during primary HIV-1 infection. Proc Natl Acad Sci U S A 1998; 95:8869-8873.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8869-8873
    • Chun, T.W.1    Engel, D.2    Berrey, M.M.3    Shea, T.4    Corey, L.5    Fauci, A.S.6
  • 7
    • 34447310001 scopus 로고    scopus 로고
    • Acute HIV infection: The impact of antiretroviral treatment on cellular immune responses
    • Hicks CB, Gay C, Ferrari G. Acute HIV infection: the impact of antiretroviral treatment on cellular immune responses. Clin Exp Immunol 2007; 149:211-216.
    • (2007) Clin Exp Immunol , vol.149 , pp. 211-216
    • Hicks, C.B.1    Gay, C.2    Ferrari, G.3
  • 8
    • 4644342929 scopus 로고    scopus 로고
    • CD4R T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    • Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, et al. CD4R T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004; 200:749-759.
    • (2004) J Exp Med , vol.200 , pp. 749-759
    • Brenchley, J.M.1    Schacker, T.W.2    Ruff, L.E.3    Price, D.A.4    Taylor, J.H.5    Beilman, G.J.6
  • 10
    • 0028792184 scopus 로고
    • In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
    • Chun TW, Finzi D, Margolick J, Chadwick K, Schwartz D, Siliciano RF. In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat Med 1995; 1:1284-1290.
    • (1995) Nat Med , vol.1 , pp. 1284-1290
    • Chun, T.W.1    Finzi, D.2    Margolick, J.3    Chadwick, K.4    Schwartz, D.5    Siliciano, R.F.6
  • 11
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4R T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, et al. Latent infection of CD4R T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999; 5:512-517.
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3    Margolick, J.B.4    Chadwick, K.5    Pierson, T.6
  • 12
    • 55949083820 scopus 로고    scopus 로고
    • HIV rebounds from latently infected cells, rather than from continuing low-level replication
    • Joos B, Fischer M, Kuster H, Pillai SK, Wong JK, Boni J, et al. HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proc Natl Acad Sci U S A 2008; 105:16725-16730.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16725-16730
    • Joos, B.1    Fischer, M.2    Kuster, H.3    Pillai, S.K.4    Wong, J.K.5    Boni, J.6
  • 13
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • Gulick RM, Mellors JW, Havlir D, Eron JJ, Gonzalez C, McMahon D, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 1997; 337:734-739.
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1    Mellors, J.W.2    Havlir, D.3    Eron, J.J.4    Gonzalez, C.5    McMahon, D.6
  • 14
    • 0001027244 scopus 로고    scopus 로고
    • A randomized trial of high-versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection
    • Davey RT Jr, Chaitt DG, Albert JM, Piscitelli SC, Kovacs JA, Walker RE, et al. A randomized trial of high-versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection. J Infect Dis 1999; 179:849-858.
    • (1999) J Infect Dis , vol.179 , pp. 849-858
    • Davey Jr., R.T.1    Chaitt, D.G.2    Albert, J.M.3    Piscitelli, S.C.4    Kovacs, J.A.5    Walker, R.E.6
  • 15
    • 0242268402 scopus 로고    scopus 로고
    • Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
    • Brooks DG, Arlen PA, Gao L, Kitchen CM, Zack JA. Identification of T cell-signaling pathways that stimulate latent HIV in primary cells. Proc Natl Acad Sci U S A 2003; 100:12955-12960.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12955-12960
    • Brooks, D.G.1    Arlen, P.A.2    Gao, L.3    Kitchen, C.M.4    Zack, J.A.5
  • 17
    • 77949592502 scopus 로고    scopus 로고
    • Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4R cell infection
    • Archin NM, Cheema M, Parker D, Wiegand A, Bosch RJ, Coffin JM, et al. Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4R cell infection. PLoS One 2010; 5:1-4.
    • (2010) PLoS One , vol.5 , pp. 1-4
    • Archin, N.M.1    Cheema, M.2    Parker, D.3    Wiegand, A.4    Bosch, R.J.5    Coffin, J.M.6
  • 18
    • 50949131800 scopus 로고    scopus 로고
    • Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4R T cells
    • Archin NM, Eron JJ, Palmer S, Hartmann-Duff A, Martinson JA, Wiegand A, et al. Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4R T cells. AIDS 2008; 22:1131-1135.
    • (2008) AIDS , vol.22 , pp. 1131-1135
    • Archin, N.M.1    Eron, J.J.2    Palmer, S.3    Hartmann-Duff, A.4    Martinson, J.A.5    Wiegand, A.6
  • 19
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, Liberty AL, Kashuba AD, Choudhary SK, Kuruc JD, Crooks AM, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012; 487:482-485.
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3    Choudhary, S.K.4    Kuruc, J.D.5    Crooks, A.M.6
  • 20
  • 21
    • 79958136377 scopus 로고    scopus 로고
    • Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4R T cell model without inducing global T cell activation
    • Xing S, Bullen CK, Shroff NS, Shan L, Yang HC, Manucci JL, et al. Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4R T cell model without inducing global T cell activation. J Virology 2011; 85:6060-6064.
    • (2011) J Virology , vol.85 , pp. 6060-6064
    • Xing, S.1    Bullen, C.K.2    Shroff, N.S.3    Shan, L.4    Yang, H.C.5    Manucci, J.L.6
  • 22
    • 47949131197 scopus 로고    scopus 로고
    • HIV integrase inhibitors: Out of the pipeline and into the clinic
    • Havlir DV. HIV integrase inhibitors: out of the pipeline and into the clinic. N Engl J Med 2008; 359:416-418.
    • (2008) N Engl J Med , vol.359 , pp. 416-418
    • Havlir, D.V.1
  • 23
    • 79954988179 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men
    • Brown KC, Patterson KB, Malone SA, Shaheen NJ, Prince HM, Dumond JB, et al. Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men. J Infect Dis 2011; 203:1484-1490.
    • (2011) J Infect Dis , vol.203 , pp. 1484-1490
    • Brown, K.C.1    Patterson, K.B.2    Malone, S.A.3    Shaheen, N.J.4    Prince, H.M.5    Dumond, J.B.6
  • 24
    • 84867005260 scopus 로고    scopus 로고
    • Single and multiple dose pharma-cokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men
    • Brown KC, Patterson KB, Jennings SH, Malone SA, Shaheen NJ, Asher Prince HM, et al. Single and multiple dose pharma-cokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men. J Acquir Immune Defic Syndr 2012; 61:138-144.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 138-144
    • Brown, K.C.1    Patterson, K.B.2    Jennings, S.H.3    Malone, S.A.4    Shaheen, N.J.5    Asher Prince, H.M.6
  • 27
    • 84879073359 scopus 로고    scopus 로고
    • Pharmacokinetics of raltegravir in the blood plasma and genital tract of HIV-positive and HIV-negative women
    • 2010 July 18-23 Vienna, Austria
    • Patterson KB, Prince HA, White N, Wang R, Jones A, Kashuba ADM. Pharmacokinetics of raltegravir in the blood plasma and genital tract of HIV-positive and HIV-negative women. XVIII International AIDS Conference; 2010 July 18-23, 2010; Vienna, Austria.
    • (2010) XVIII International AIDS Conference
    • Patterson, K.B.1    Prince, H.A.2    White, N.3    Wang, R.4    Jones, A.5    Kashuba, A.D.M.6
  • 28
    • 77958468743 scopus 로고    scopus 로고
    • Pharmacologic opportunities for HIV prevention
    • Nicol MR, Kashuba AD. Pharmacologic opportunities for HIV prevention. Clin Pharmacol Ther 2010; 88:598-609.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 598-609
    • Nicol, M.R.1    Kashuba, A.D.2
  • 29
    • 83155177076 scopus 로고    scopus 로고
    • Penetration of tenofovir and emtricitabine in mucosal tissues: Implications for prevention of HIV-1 transmission
    • Patterson KB, Prince HA, Kraft E, Jenkins AJ, Shaheen NJ, Rooney JF, et al. Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission. Sci Transl Med 2011; 3:112re4.
    • (2011) Sci Transl Med , vol.3
    • Patterson, K.B.1    Prince, H.A.2    Kraft, E.3    Jenkins, A.J.4    Shaheen, N.J.5    Rooney, J.F.6
  • 30
    • 84879076789 scopus 로고    scopus 로고
    • Pharmacologic analysis of lymphatic reservoirs of HIV Infection
    • 2011 December 6-9 St. Maarten, West Indies
    • Fletcher C. Pharmacologic analysis of lymphatic reservoirs of HIV Infection. Fifth International Conference on HIV Persistence During Therapy; 2011 December 6-9, 2011; St. Maarten, West Indies.
    • (2011) Fifth International Conference on HIV Persistence During Therapy
    • Fletcher, C.1
  • 31
    • 84455174924 scopus 로고    scopus 로고
    • HIV/AIDS research. Tissue says blood is misleading, confusing HIV cure efforts
    • Cohen J. HIV/AIDS research. Tissue says blood is misleading, confusing HIV cure efforts. Science 2011; 334:1614.
    • (2011) Science , vol.334 , pp. 1614
    • Cohen, J.1
  • 33
    • 84866261116 scopus 로고    scopus 로고
    • A novel ultrasensitive LC-MS/MS assay for quantification of intracellular raltegravir in human cell extracts
    • Robbins BL, Nelson SR, Fletcher CV. A novel ultrasensitive LC-MS/MS assay for quantification of intracellular raltegravir in human cell extracts. J Pharm Biomed Anal 2012; 70:378-387.
    • (2012) J Pharm Biomed Anal , vol.70 , pp. 378-387
    • Robbins, B.L.1    Nelson, S.R.2    Fletcher, C.V.3
  • 34
    • 33750344235 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells
    • King T, Bushman L, Kiser J, Anderson PL, Ray M, Delahunty T, et al. Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells. J Chromat B 2006; 843:147-156.
    • (2006) J Chromat B , vol.843 , pp. 147-156
    • King, T.1    Bushman, L.2    Kiser, J.3    Anderson, P.L.4    Ray, M.5    Delahunty, T.6
  • 35
    • 84864243685 scopus 로고    scopus 로고
    • HIV: Shock and kill
    • Deeks SG. HIV: shock and kill. Nature 2012; 487:439-440.
    • (2012) Nature , vol.487 , pp. 439-440
    • Deeks, S.G.1
  • 36
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
    • Grinsztejn B, Nguyen BY, Katlama C, Gatell JM, Lazzarin A, Vittecoq D, et al. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 2007; 369:1261-1269.
    • (2007) Lancet , vol.369 , pp. 1261-1269
    • Grinsztejn, B.1    Nguyen, B.Y.2    Katlama, C.3    Gatell, J.M.4    Lazzarin, A.5    Vittecoq, D.6
  • 37
    • 33845366857 scopus 로고    scopus 로고
    • Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
    • Markowitz M, Morales-Ramirez JO, Nguyen BY, Kovacs CM, Steigbigel RT, Cooper DA, et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006; 43:509-515.
    • (2006) J Acquir Immune Defic Syndr , vol.43 , pp. 509-515
    • Markowitz, M.1    Morales-Ramirez, J.O.2    Nguyen, B.Y.3    Kovacs, C.M.4    Steigbigel, R.T.5    Cooper, D.A.6
  • 38
    • 37349120701 scopus 로고    scopus 로고
    • Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase
    • Murray JM, Emery S, Kelleher AD, Law M, Chen J, Hazuda DJ, et al. Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS 2007; 21:2315-2321.
    • (2007) AIDS , vol.21 , pp. 2315-2321
    • Murray, J.M.1    Emery, S.2    Kelleher, A.D.3    Law, M.4    Chen, J.5    Hazuda, D.J.6
  • 39
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi RT, Zheng L, Bosch RJ, Chan ES, Margolis DM, Read S, et al. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS Med 2010; 7:e1000321.
    • (2010) PLoS Med , vol.7
    • Gandhi, R.T.1    Zheng, L.2    Bosch, R.J.3    Chan, E.S.4    Margolis, D.M.5    Read, S.6
  • 40
    • 79953000877 scopus 로고    scopus 로고
    • A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4R T cell response
    • Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, et al. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4R T cell response. J Infect Dis 2011; 203:960-968.
    • (2011) J Infect Dis , vol.203 , pp. 960-968
    • Hatano, H.1    Hayes, T.L.2    Dahl, V.3    Sinclair, E.4    Lee, T.H.5    Hoh, R.6
  • 41
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, Cranmer L, et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci U S A 2009; 106:9403-9408.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3    Palmer, S.E.4    Gange, S.J.5    Cranmer, L.6
  • 42
    • 77749277080 scopus 로고    scopus 로고
    • Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy
    • McMahon D, Jones J, Wiegand A, Gange SJ, Kearney M, Palmer S, et al. Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy. Clin Infect Dis 2010; 50:912-919.
    • (2010) Clin Infect Dis , vol.50 , pp. 912-919
    • McMahon, D.1    Jones, J.2    Wiegand, A.3    Gange, S.J.4    Kearney, M.5    Palmer, S.6
  • 43
    • 78149417719 scopus 로고    scopus 로고
    • Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
    • Yukl SA, Gianella S, Sinclair E, Epling L, Li Q, Duan L, et al. Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J Infect Dis 2010; 202:1553-1561.
    • (2010) J Infect Dis , vol.202 , pp. 1553-1561
    • Yukl, S.A.1    Gianella, S.2    Sinclair, E.3    Epling, L.4    Li, Q.5    Duan, L.6
  • 44
    • 84859250847 scopus 로고    scopus 로고
    • Impact of multitargeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
    • Ananworanich J, Schuetz A, Vandergeeten C, Sereti I, de Souza M, Rerknimitr R, et al. Impact of multitargeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS One 2012; 7:e33948.
    • (2012) PLoS One , vol.7
    • Ananworanich, J.1    Schuetz, A.2    Vandergeeten, C.3    Sereti, I.4    De Souza, M.5    Rerknimitr, R.6
  • 45
    • 84864051807 scopus 로고    scopus 로고
    • A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model
    • Shytaj IL, Norelli S, Chirullo B, Della Corte A, Collins M, Yalley-Ogunro J, et al. A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model. PLoS Pathog 2012; 8:e1002774.
    • (2012) PLoS Pathog , vol.8
    • Shytaj, I.L.1    Norelli, S.2    Chirullo, B.3    Della Corte, A.4    Collins, M.5    Yalley-Ogunro, J.6


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