Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry

Journal of Mass Spectrometry

Volumn 38, Issue 10, 2003, Pages 1081-1092

  Reyzer, Michelle L ^a   Hsieh, Yunsheng ^b   Ng, Kwokei ^b   Korfmacher, Walter A ^b   Caprioli, Richard M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Drugs; Imaging; MALDI; MS MS; QqTOF

Indexed keywords

BRAIN; COMPUTER SOFTWARE; DRUG DOSAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LASER BEAM EFFECTS; TISSUE; TUMORS;

IONIZATION MASS SPECTROMETRY; TANDEM MASS SPECTROMETRY;

MASS SPECTROMETRY;

ANTINEOPLASTIC AGENT; LONAFARNIB; SCH 226374; SINAPIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN TISSUE; COMPUTER PROGRAM; CONTROLLED STUDY; CORRELATION ANALYSIS; DISSOCIATION; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE ANALYSIS; MASS SPECTROMETER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; BRAIN; COUMARIC ACIDS; IMIDAZOLES; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PIPERAZINES; RATS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE EXTRACTS;

EID: 0242606377     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.525     Document Type: Article

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