Determination of the antiretroviral drug tenofovir in plasma from HIV-infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry

Journal of Mass Spectrometry

Volumn 46, Issue 3, 2011, Pages 282-289

  Meesters, Roland J W ^a   Van Kampen, Jeroen J A ^a   Scheuer, Rachel D ^a   Van Der Ende, Marchina E ^a   Gruters, Rob A ^a   Luider, Theo M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Isotope dilution method; MALDI QqQ MS MS; Multiple reaction monitoring; Tenofovir; Tenofovir disoproxil fumarate

Indexed keywords

ANTIRETROVIRAL DRUGS; CLINICAL FEASIBILITY; CONCENTRATION RANGES; DEPROTEINIZATION; FUMARATES; HIGH-THROUGHPUT MEASUREMENTS; HUMAN CONTROL; INTERNAL STANDARDS; ISOTOPE DILUTION METHODS; ISOTOPE DILUTIONS; LIMIT OF DETECTION; LIMIT OF QUANTIFICATIONS; MALDI-QQQ-MS/MS; MATRIX ASSISTED LASER DESORPTION/IONIZATION; MULTIPLE REACTION MONITORING; PLASMA SAMPLES; PRODRUGS; SIGNAL TO NOISE; SPECTROMETRIC METHODS; TENOFOVIR; TRIPLE QUADRUPOLE TANDEM MASS SPECTROMETRY; ULTRA-FAST; VALIDATED METHODS;

CONCENTRATION (PROCESS); DESORPTION; DILUTION; DISEASES; ISOTOPES; MASS SPECTROMETRY; MONITORING; SIGNAL TO NOISE RATIO;

PLASMAS;

ADENINE; ANTIRETROVIRUS AGENT; ATAZANAVIR; CARBON 13; LOPINAVIR PLUS RITONAVIR; PROTEINASE INHIBITOR; RITONAVIR; TENOFOVIR; TENOFOVIR DISOPROXIL;

ADULT; ARTICLE; BLOOD SAMPLING; CALIBRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFICACY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTRIGLYCERIDEMIA; MATRIX ASSISTED LASER DESORPTION IONIZATION TRIPLE QUADRUPOLE TANDEM MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; RELIABILITY; TANDEM MASS SPECTROMETRY; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; VALIDATION STUDY;

ADENINE; ADULT; ANTI-HIV AGENTS; HIV INFECTIONS; HUMANS; ISOTOPE LABELING; LINEAR MODELS; PHOSPHONIC ACIDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY; TRIGLYCERIDES;

EID: 79952545933     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1897     Document Type: Article

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