Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: An LC-MS and matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity

Chemical Research in Toxicology

Volumn 26, Issue 2, 2013, Pages 241-251

  Castellino, Stephen ^a   Groseclose, M Reid ^a   Sigafoos, James ^a   Wagner, David ^a   De Serres, Mark ^a   Polli, Joseph W ^a   Romach, Elizabeth ^a   Myer, James ^a   Hamilton, Brad ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOSDEVIRINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN HOMOGENATE; BRAIN TISSUE; CASE REPORT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG STRUCTURE; GRAY MATTER; HAPLORHINI; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICHAEL ADDITION; MINIPIG; NEUROTOXICITY; NONHUMAN; PHASE 2 CLINICAL TRIAL; RABBIT; SEIZURE; TREATMENT DURATION; WHITE MATTER;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY, LIQUID; FEMALE; HAPLORHINI; HUMANS; INDOLES; MALE; PHOSPHINIC ACIDS; RABBITS; REVERSE TRANSCRIPTASE INHIBITORS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE; SWINE, MINIATURE;

EID: 84874028596     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx3004196     Document Type: Article

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