Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method

Analytical Chemistry

Volumn 83, Issue 24, 2011, Pages 9694-9701

  Goodwin, Richard J A ^a,c   MacKay, C Logan ^b   Nilsson, Anna ^c   Harrison, David J ^b   Farde, Lars ^d,e   Andren, Per E ^c   Iverson, Suzanne L ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURATE MASS; ADJACENT VEHICLES; APPLICATION METHOD; ISOTOPE DISTRIBUTIONS; KIDNEY TISSUES; LINEAR RESPONSE; MALDI MATRIX; MALDI-TOF/TOF; MASS-TO-CHARGE RATIO; MATRIX; MATRIX COATING; MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY; MS/MS FRAGMENTATION; QUANTITATIVE DATA; RAT BRAIN TISSUE; RECEPTOR ANTAGONISTS; RESEARCH DEVELOPMENT; SOLVENT FREE; TARGET COMPOUND; TISSUE CONCENTRATIONS; TISSUE SECTIONS;

BRAIN; CONTROL SYSTEM SYNTHESIS; DESORPTION; DRUG DOSAGE; ISOTOPES; LIGANDS; MASS SPECTROMETRY; MATRIX ALGEBRA; POSITRONS; RATS; SOLVENTS; TISSUE;

POSITRON EMISSION TOMOGRAPHY;

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BENZAZEPINE DERIVATIVE; DOPAMINE RECEPTOR BLOCKING AGENT; INDIUM TIN OXIDE; LIGAND; RACLOPRIDE; TIN DERIVATIVE;

ANIMAL; ARTICLE; BRAIN; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; POSITRON EMISSION TOMOGRAPHY; RAT; SCINTISCANNING; SPRAGUE DAWLEY RAT;

ANIMALS; BENZAZEPINES; BRAIN; DOPAMINE ANTAGONISTS; LIGANDS; POSITRON-EMISSION TOMOGRAPHY; RACLOPRIDE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIN COMPOUNDS;

EID: 83655172683     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac202630t     Document Type: Article

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