Determination of loperamide in Mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis

Archives of Pharmacal Research

Volumn 34, Issue 11, 2011, Pages 1983-1988

  Shin, Young G ^a   Dong, Teresa ^a   Chou, Bilin ^a   Menghrajani, Kapil ^a  

^a Department of Drug Metabolism and Pharmacokinetics ^*  (United States)

Author keywords

ESI LC MS MS; Loperamide; Matrix assisted laser desoprtion ionization (MALDI); Mdr1a 1b( ); Quantitation; Tissue analysis

Indexed keywords

ACETONITRILE; ALPHA CYANO 4 HYDROXYCINNAMIC ACID; GLYCOPROTEIN P; LOPERAMIDE; RESERPINE; TRIFLUOROACETIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; INTERMETHOD COMPARISON; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; QUADRUPOLE MASS SPECTROMETRY; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTIDIARRHEALS; BRAIN; CALIBRATION; DRUG DISCOVERY; DRUGS, INVESTIGATIONAL; LIMIT OF DETECTION; LOPERAMIDE; MICE; MICE, KNOCKOUT; MICROCHEMISTRY; NERVE TISSUE PROTEINS; NEUROIMAGING; P-GLYCOPROTEINS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE DISTRIBUTION;

EID: 83655182569     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-1119-7     Document Type: Article

References (15)

1. F. O. Ayorinde P. Hambright T. N. Porter Q. L. Keith Jr. 1999 Use of meso-tetrakis(pentafluorophenyl)porphyrin as a matrix for low molecular weight alkylphenol ethoxylates in laser desorption/ionization time-of-flight mass spectrometry Rapid Commun. Mass Spectrom. 13 2474 2479 10589096 10.1002/(SICI)1097-0231(19991230)13:24<2474::AID-RCM814>3.0.CO;2-0 1:CAS:528:DC%2BD3cXhtFSqug%3D%3D
2. A. Brunelle D. Touboul O. Laprévote 2005 Biological tissue imaging with time-of-flight secondary ion mass spectrometry and cluster ion sources J. Mass Spectrom. 40 985 999 16106340 10.1002/jms.902 1:CAS:528: DC%2BD2MXpvFKqu7Y%3D (Pubitemid 41284732)
3. Y. C. Chen J. Shiea J. Sunner 2000 Rapid determination of trace nitrophenolic organics in water by combining solid-phase extraction with surface-assisted laser desorption/ionization time-of-flight mass spectrometry Rapid Commun. Mass Spectrom. 14 86 90 10623934 10.1002/(SICI)1097-0231(20000130) 14:2<86::AID-RCM839>3.0.CO;2-O (Pubitemid 30047325)
4. Z. Guo Q. Zhang H. Zou B. Guo J. Ni 2002 A method for the analysis of low-mass molecules by MALDI-TOF mass spectrometry Anal. Chem. 74 1637 1641 12033256 10.1021/ac010979m 1:CAS:528:DC%2BD38XhsF2ls7o%3D (Pubitemid 34297603)
5. Y. Hsieh R. Casale E. Fukuda J. Chen I. Knemeyer J. Wingate R. Morrison W. Korfmacher 2006 Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue Rapid Commun. Mass Spectrom. 20 965 972 16470674 10.1002/rcm.2397 1:CAS:528: DC%2BD28XjtFCgs7Y%3D
6. J. C. Kalvass C. L. Graff G. M. Pollack 2004 Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice Pharm. Res. 21 1867 1870 15553234 10.1023/B:PHAM.0000045241.26925.8b 1:CAS:528:DC%2BD2cXos1Wqt78%3D (Pubitemid 39390099)
7. S. Khatib-Shahidi M. Andersson J. L. Herman T. A. Gillespie R. M. Caprioli 2006 Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry Anal. Chem. 78 6448 6456 16970320 10.1021/ac060788p 1:CAS:528:DC%2BD28XnsF2iurg%3D (Pubitemid 44418954)
8. C. Lechene F. Hillion G. McMahon D. Benson A. M. Kleinfeld J. P. Kampf D. Distel Y. Luyten J. Bonventre D. Hentschel K. M. Park S. Ito M. Schwartz G. Benichou G. Slodzian 2006 High-resolution quantitative imaging of massalian and bacterial cells using stable isotope mass spectrometry J. Biol. 5 20 26 17010211 10.1186/jbiol42
9. M. L. Reyzer Y. Hsieh K. Ng W. A. Korfmacher R. M. Caprioli 2003 Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry J. Mass Spectrom. 38 1081 1092 14595858 10.1002/jms.525 1:CAS:528:DC%2BD3sXovFCltb4%3D (Pubitemid 37407703)
10. M. L. Reyzer R. L. Caldwell T. C. Dugger J. T. Forbes C. A. Ritter M. Guix C. L. Arteaga R. M. Caprioli 2004 Early changes in protein expression detected by mass spectrometry predict tumor response to molecular therapeutics Cancer Res. 64 9093 9100 15604278 10.1158/0008-5472.CAN-04-2231 1:CAS:528:DC%2BD2cXhtVOmsLbE (Pubitemid 39665523)
11. L. Sleno D. A. Volmer 2005 Some fundamental and technical aspects of the quantitative analysis of pharmaceutical drugs by matrix-assisted laser desorption/ionization mass spectrometry Rapid Commun. Mass Spectrom. 19 1928 1936 15954169 10.1002/rcm.2006 1:CAS:528:DC%2BD2MXmslCrtb0%3D (Pubitemid 41026413)
12. M. Stoeckli P. Chaurand D. E. Hallahan R. M. Caprioli 2001 Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues Nat. Med. 7 493 496 11283679 10.1038/86573 1:CAS:528:DC%2BD3MXis1yksLo%3D (Pubitemid 32298555)
13. K. Tanaka H. Waki Y. Ido S. Akita Y. Yoshida T. Yoshida 1988 Protein and polymer analyses up to m/z 100,000 by laser ionization time-of-flight mass spectrometry Rapid Commun. Mass Spectrom. 2 151 153 10.1002/rcm.1290020802 1:CAS:528:DyaK3cXjtVSgug%3D%3D
14. J. Vandenbossche M. Huisman Y. Xu D. Sanderson-Bongiovanni P. Soons 2010 Loperamide and P-glycoprotein inhibition: assessment of the clinical relevance J. Pharm. Pharmacol. 62 401 412 20604828 1:CAS:528:DC%2BC3cXlsFWnurc%3D
15. J. Wei J. M. Buriak G. Siuzdak 1999 Desorption-ionization mass spectrometry on porous silicon Nature 399 243 246 10353246 10.1038/20400 1:CAS:528:DyaK1MXjsFyku7c%3D (Pubitemid 29246449)