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Volumn 8, Issue OCT, 2014, Pages 1-11

Early life stress and serotonin transporter gene variation interact to affect the transcription of the glucocorticoid and mineralocorticoid receptors, and the co-chaperone FKBP5, in the adult rat brain

Author keywords

Depression; Early life stress; FKBP5; Glucocorticoid receptor; Hippocampus; Medial prefrontal cortex; Mineralocorticoid receptor; Serotonin transporter

Indexed keywords

CHAPERONE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 51; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

EID: 84907963640     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2014.00355     Document Type: Article
Times cited : (29)

References (83)
  • 1
    • 33947155494 scopus 로고    scopus 로고
    • Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats
    • Aisa, B., Tordera, R., Lasheras, B., Del Río, J., and Ramírez, M. J. (2007). Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 32, 256-266. doi: 10.1016/j.psyneuen.2006.12.013
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 256-266
    • Aisa, B.1    Tordera, R.2    Lasheras, B.3    Del Río, J.4    Ramírez, M.J.5
  • 2
    • 14544297378 scopus 로고    scopus 로고
    • Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus
    • Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., and Maier, S. F. (2005). Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat. Neurosci. 8, 365-371. doi: 10.1038/nn1399
    • (2005) Nat. Neurosci. , vol.8 , pp. 365-371
    • Amat, J.1    Baratta, M.V.2    Paul, E.3    Bland, S.T.4    Watkins, L.R.5    Maier, S.F.6
  • 3
    • 0031978809 scopus 로고    scopus 로고
    • Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice
    • Bengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D., Heils, A., et al. (1998). Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 53, 649-655.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 649-655
    • Bengel, D.1    Murphy, D.L.2    Andrews, A.M.3    Wichems, C.H.4    Feltner, D.5    Heils, A.6
  • 4
    • 0032096445 scopus 로고    scopus 로고
    • Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field
    • Biagini, G., Pich, E. M., Carani, C., Marrama, P., and Agnati, L. F. (1998). Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field. Int. J. Dev. Neurosci. 16, 187-197. doi: 10.1016/S0736-5748(98)00019-7
    • (1998) Int. J. Dev. Neurosci. , vol.16 , pp. 187-197
    • Biagini, G.1    Pich, E.M.2    Carani, C.3    Marrama, P.4    Agnati, L.F.5
  • 5
    • 70350731477 scopus 로고    scopus 로고
    • The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders
    • Binder, E. B. (2009). The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 34S, S186-S195. doi: 10.1016/j.psyneuen.2009.05.021
    • (2009) Psychoneuroendocrinology , vol.34 S , pp. S186-S195
    • Binder, E.B.1
  • 6
    • 0003743345 scopus 로고
    • Bethesda, MD: U.S. Department of Health, Education, and Welfare, Public Health Service
    • Calhoun, J. B. (1962). The Ecology and Sociology of the Norway Rat. Bethesda, MD: U.S. Department of Health, Education, and Welfare, Public Health Service.
    • (1962) The Ecology and Sociology of the Norway Rat.
    • Calhoun, J.B.1
  • 7
    • 41449111073 scopus 로고    scopus 로고
    • Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression
    • Carola, V., Frazzetto, G., Pascucci, T., Audero, E., Puglisi-Allegra, S., Cabib, S., et al. (2008). Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression. Biol. Psychiatry 63, 840-846. doi: 10.1016/j.biopsych.2007.08.013
    • (2008) Biol. Psychiatry , vol.63 , pp. 840-846
    • Carola, V.1    Frazzetto, G.2    Pascucci, T.3    Audero, E.4    Puglisi-Allegra, S.5    Cabib, S.6
  • 8
    • 77951854270 scopus 로고    scopus 로고
    • Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits
    • Caspi, A., Hariri, A. R., Holmes, A., Uher, R., and Moffitt, T. E. (2010). Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am. J. Psychiatry 167, 509-527. doi: 10.1176/appi.ajp.2010.09101452
    • (2010) Am. J. Psychiatry , vol.167 , pp. 509-527
    • Caspi, A.1    Hariri, A.R.2    Holmes, A.3    Uher, R.4    Moffitt, T.E.5
  • 9
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386-389. doi: 10.1126/science.1083968
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3    Taylor, A.4    Craig, I.W.5    Harrington, H.6
  • 10
    • 62849097441 scopus 로고    scopus 로고
    • Fundamental aspects of the impact of glucocorticoids on the (immature) brain
    • Champagne, D. L., De Kloet, E. R., and Joëls, M. (2009). Fundamental aspects of the impact of glucocorticoids on the (immature) brain. Semin. Fetal Neonatal Med. 14, 136-142. doi: 10.1016/j.siny.2008.11.006
    • (2009) Semin. Fetal Neonatal Med. , vol.14 , pp. 136-142
    • Champagne, D.L.1    De Kloet, E.R.2    Joëls, M.3
  • 11
    • 0029761144 scopus 로고    scopus 로고
    • The neuroendocrinology of depression and chronic stress
    • Checkley, S. (1996). The neuroendocrinology of depression and chronic stress. Br. Med. Bull. 52, 597-617. doi: 10.1093/oxfordjournals.bmb.a011570
    • (1996) Br. Med. Bull. , vol.52 , pp. 597-617
    • Checkley, S.1
  • 12
    • 84862503178 scopus 로고    scopus 로고
    • Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity
    • Daskalakis, N. P., Oitzl, M. S., Schächinger, H., Champagne, D. L., and De Kloet, E. R. (2012). Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiol. Behav. 106, 707-721. doi: 10.1016/j.physbeh.2012.01.015
    • (2012) Physiol. Behav. , vol.106 , pp. 707-721
    • Daskalakis, N.P.1    Oitzl, M.S.2    Schächinger, H.3    Champagne, D.L.4    De Kloet, E.R.5
  • 13
    • 20044395965 scopus 로고    scopus 로고
    • Stress and the brain: From adaptation to disease
    • De Kloet, E. R., Joëls, M., and Holsboer, F. (2005). Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6, 463-475. doi: 10.1038/nrn1683
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 463-475
    • De Kloet, E.R.1    Joëls, M.2    Holsboer, F.3
  • 14
    • 0032467785 scopus 로고    scopus 로고
    • Brain corticosteroid receptor balance in health and disease
    • De Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., and Joëls, M. (1998). Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 19, 269-301.
    • (1998) Endocr. Rev. , vol.19 , pp. 269-301
    • De Kloet, E.R.1    Vreugdenhil, E.2    Oitzl, M.S.3    Joëls, M.4
  • 15
    • 52949140212 scopus 로고    scopus 로고
    • Housekeeping genes revisited: Different expressions depending on gender, brain area and stressor
    • Derks, N. M., Müller, M., Gaszner, B., Tilburg-Ouwens, D. T. W. M., Roubos, E. W., and Kozicz, T. (2008). Housekeeping genes revisited: different expressions depending on gender, brain area and stressor. Neuroscience156, 305-309. doi: 10.1016/j.neuroscience.2008.07.047
    • (2008) Neuroscience , vol.156 , pp. 305-309
    • Derks, N.M.1    Müller, M.2    Gaszner, B.3    Tilburg-Ouwens, D.T.W.M.4    Roubos, E.W.5    Kozicz, T.6
  • 16
    • 80855138134 scopus 로고    scopus 로고
    • Membrane mineralocorticoid but not glucocorticoid receptors of the dorsal hippocampus mediate the rapid effects of corticosterone on memory retrieval
    • Dorey, R., Piérard, C., Shinkaruk, S., Tronche, C., Chauveau, F., Baudonnat, M., et al. (2011). Membrane mineralocorticoid but not glucocorticoid receptors of the dorsal hippocampus mediate the rapid effects of corticosterone on memory retrieval. Neuropsychopharmacology 36, 2639-2649. doi: 10.1038/npp.2011.152
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2639-2649
    • Dorey, R.1    Piérard, C.2    Shinkaruk, S.3    Tronche, C.4    Chauveau, F.5    Baudonnat, M.6
  • 17
    • 0034082010 scopus 로고    scopus 로고
    • The long-term effects of maternal deprivation depend on the genetic background
    • Ellenbroek, B. A., and Cools, A. R. (2000). The long-term effects of maternal deprivation depend on the genetic background. Neuropsychopharmacology 23, 99-106. doi: 10.1016/S0893-133X(00)00088-9
    • (2000) Neuropsychopharmacology , vol.23 , pp. 99-106
    • Ellenbroek, B.A.1    Cools, A.R.2
  • 18
    • 73549123839 scopus 로고    scopus 로고
    • Are the dorsal and ventral hippocampus functionally distinct structures?
    • Fanselow, M. S., and Dong, H.-W. (2010). Are the dorsal and ventral hippocampus functionally distinct structures?Neuron 65, 7-19. doi: 10.1016/j.neuron.2009.11.031
    • (2010) Neuron , vol.65 , pp. 7-19
    • Fanselow, M.S.1    Dong, H.-W.2
  • 19
    • 0037107176 scopus 로고    scopus 로고
    • Environmental enrichment reverses the effects of maternal separation on stress reactivity
    • Francis, D. D., Diorio, J., Plotsky, P. M., and Meaney, M. J. (2002). Environmental enrichment reverses the effects of maternal separation on stress reactivity. J. Neurosci. 22, 7840-7843.
    • (2002) J. Neurosci. , vol.22 , pp. 7840-7843
    • Francis, D.D.1    Diorio, J.2    Plotsky, P.M.3    Meaney, M.J.4
  • 20
    • 33846058958 scopus 로고    scopus 로고
    • Early life events and their consequences for later disease: A life history and evolutionary perspective
    • Gluckman, P. D., Hanson, M. A., and Beedle, A. S. (2007). Early life events and their consequences for later disease: a life history and evolutionary perspective. Am. J. Hum. Biol. 19, 1-19. doi: 10.1002/ajhb.20590
    • (2007) Am. J. Hum. Biol. , vol.19 , pp. 1-19
    • Gluckman, P.D.1    Hanson, M.A.2    Beedle, A.S.3
  • 21
    • 0036212671 scopus 로고    scopus 로고
    • Organization of the stress system and its dysregulation in melancholic and atypical depression: High vs low CRH/NE states
    • Gold, P. W., and Chrousos, G. P. (2002). Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry 7, 254-275. doi: 10.1038/sj.mp.4001032
    • (2002) Mol. Psychiatry , vol.7 , pp. 254-275
    • Gold, P.W.1    Chrousos, G.P.2
  • 22
    • 58149470815 scopus 로고    scopus 로고
    • A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF
    • Gourley, S. L., Kedves, A. T., Olausson, P., and Taylor, J. R. (2009). A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF. Neuropsychopharmacology 34, 707-716. doi: 10.1038/npp.2008.123
    • (2009) Neuropsychopharmacology , vol.34 , pp. 707-716
    • Gourley, S.L.1    Kedves, A.T.2    Olausson, P.3    Taylor, J.R.4
  • 23
    • 0033525170 scopus 로고    scopus 로고
    • Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets
    • Greenberg, B. D., Tolliver, T. J., Huang, S.-J., Li, Q., Bengel, D., and Murphy, D. L. (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am. J. Med. Genet. 88, 83-87.
    • (1999) Am. J. Med. Genet. , vol.88 , pp. 83-87
    • Greenberg, B.D.1    Tolliver, T.J.2    Huang, S.-J.3    Li, Q.4    Bengel, D.5    Murphy, D.L.6
  • 24
    • 84873743622 scopus 로고    scopus 로고
    • Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: Modulation by antidepressant treatment
    • Guidotti, G., Calabrese, F., Anacker, C., Racagni, G., Pariante, C. M., and Riva, M. A. (2013). Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: modulation by antidepressant treatment. Neuropsychopharmacology 38, 616-627. doi: 10.1038/npp.2012.225
    • (2013) Neuropsychopharmacology , vol.38 , pp. 616-627
    • Guidotti, G.1    Calabrese, F.2    Anacker, C.3    Racagni, G.4    Pariante, C.M.5    Riva, M.A.6
  • 25
    • 80054096224 scopus 로고    scopus 로고
    • The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress
    • Hartmann, J., Wagner, K. V., Liebl, C., Scharf, S. H., Wang, X.-D., Wolf, M., et al. (2012). The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology 62, 332-339. doi: 10.1016/j.neuropharm.2011.07.041
    • (2012) Neuropharmacology , vol.62 , pp. 332-339
    • Hartmann, J.1    Wagner, K.V.2    Liebl, C.3    Scharf, S.H.4    Wang, X.-D.5    Wolf, M.6
  • 26
    • 0029895783 scopus 로고    scopus 로고
    • Allelic variation of human serotonin transporter gene expression
    • Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., et al. (1996). Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66, 2621-2624. doi: 10.1046/j.1471-4159.1996.66062621.x
    • (1996) J. Neurochem. , vol.66 , pp. 2621-2624
    • Heils, A.1    Teufel, A.2    Petri, S.3    Stöber, G.4    Riederer, P.5    Bengel, D.6
  • 27
    • 0345305849 scopus 로고    scopus 로고
    • Abnormal anxiety-related behavior in serotonin transporter null mutant mice: The influence of genetic background
    • Holmes, A., Li, Q., Murphy, D. L., Gold, E., and Crawley, J. N. (2003). Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav. 2, 365-380. doi: 10.1046/j.1601-1848.2003.00050.x
    • (2003) Genes Brain Behav. , vol.2 , pp. 365-380
    • Holmes, A.1    Li, Q.2    Murphy, D.L.3    Gold, E.4    Crawley, J.N.5
  • 28
    • 0033797445 scopus 로고    scopus 로고
    • The corticosteroid receptor hypothesis of depression
    • Holsboer, F. (2000). The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23, 477-501. doi: 10.1016/S0893-133X(00)00159-7
    • (2000) Neuropsychopharmacology , vol.23 , pp. 477-501
    • Holsboer, F.1
  • 29
    • 34249080888 scopus 로고    scopus 로고
    • Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system
    • Homberg, J. R., Olivier, J. D., Smits, B. M. G., Mul, J. D., Mudde, J., Verheul, M., et al. (2007). Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience 146, 1662-1676. doi: 10.1016/j.neuroscience.2007.03.030
    • (2007) Neuroscience , vol.146 , pp. 1662-1676
    • Homberg, J.R.1    Olivier, J.D.2    Smits, B.M.G.3    Mul, J.D.4    Mudde, J.5    Verheul, M.6
  • 30
    • 84867899489 scopus 로고    scopus 로고
    • The serotonin transporter gene and functional and pathological adaptation to environmental variation across the life span
    • Homberg, J. R., and van den Hove, D. L. A. (2012). The serotonin transporter gene and functional and pathological adaptation to environmental variation across the life span. Prog. Neurobiol. 99, 117-127. doi: 10.1016/j.pneurobio.2012.08.003
    • (2012) Prog. Neurobiol. , vol.99 , pp. 117-127
    • Homberg, J.R.1    van den Hove, D.L.A.2
  • 31
    • 0025015350 scopus 로고
    • Nest temperature: Effects on maternal behavior, pup development, and interactions with handling
    • Jans, J. E., and Woodside, B. C. (1990). Nest temperature: effects on maternal behavior, pup development, and interactions with handling. Dev. Psychobiol. 23, 519-534. doi: 10.1002/dev.420230607
    • (1990) Dev. Psychobiol. , vol.23 , pp. 519-534
    • Jans, J.E.1    Woodside, B.C.2
  • 32
    • 72449207509 scopus 로고    scopus 로고
    • Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes
    • Kalueff, A. V., Olivier, J. D. A., Nonkes, L. J. P., and Homberg, J. R. (2010). Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes. Neurosci. Biobehav. Rev. 34, 373-386. doi: 10.1016/j.neubiorev.2009.08.003
    • (2010) Neurosci. Biobehav. Rev. , vol.34 , pp. 373-386
    • Kalueff, A.V.1    Olivier, J.D.A.2    Nonkes, L.J.P.3    Homberg, J.R.4
  • 33
    • 79952033418 scopus 로고    scopus 로고
    • The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation
    • Karg, K., Burmeister, M., Shedden, K., and Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch. Gen. Psychiatry 68, 444-454. doi: 10.1001/archgenpsychiatry.2010.189
    • (2011) Arch. Gen. Psychiatry , vol.68 , pp. 444-454
    • Karg, K.1    Burmeister, M.2    Shedden, K.3    Sen, S.4
  • 34
    • 84876291637 scopus 로고    scopus 로고
    • Diverging neural pathways assemble a behavioural state from separable features in anxiety
    • Kim, S.-Y., Adhikari, A., Lee, S. Y., Marshel, J. H., Kim, C. K., Mallory, C. S., et al. (2013). Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature 496, 219-223. doi: 10.1038/nature12018
    • (2013) Nature , vol.496 , pp. 219-223
    • Kim, S.-Y.1    Adhikari, A.2    Lee, S.Y.3    Marshel, J.H.4    Kim, C.K.5    Mallory, C.S.6
  • 35
    • 84871717397 scopus 로고    scopus 로고
    • Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions
    • Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., et al. (2013). Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci. 16, 33-41. doi: 10.1038/nn.3275
    • (2013) Nat. Neurosci. , vol.16 , pp. 33-41
    • Klengel, T.1    Mehta, D.2    Anacker, C.3    Rex-Haffner, M.4    Pruessner, J.C.5    Pariante, C.M.6
  • 36
    • 79958767459 scopus 로고    scopus 로고
    • Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder
    • Klok, M. D., Alt, S. R., Irurzun Lafitte, A. J. M., Turner, J. D., Lakke, E. A. J. F., Huitinga, I., et al. (2011a). Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder. J. Psychiatr. Res. 45, 871-878. doi: 10.1016/j.jpsychires.2010.12.002
    • (2011) J. Psychiatr. Res. , vol.45 , pp. 871-878
    • Klok, M.D.1    Alt, S.R.2    Irurzun Lafitte, A.J.M.3    Turner, J.D.4    Lakke, E.A.J.F.5    Huitinga, I.6
  • 37
    • 83755170516 scopus 로고    scopus 로고
    • A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females
    • Klok, M. D., Giltay, E. J., Van der Does, J. W., Geleijnse, J. M., Antypa, N., Penninx, B. W. J. H., et al. (2011b). A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females. Transl. Psychiatry 1:e62. doi: 10.1038/tp.2011.59
    • (2011) Transl. Psychiatry , vol.1
    • Klok, M.D.1    Giltay, E.J.2    Van der Does, J.W.3    Geleijnse, J.M.4    Antypa, N.5    Penninx, B.W.J.H.6
  • 38
    • 1042277738 scopus 로고    scopus 로고
    • Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation
    • Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., and Plotsky, P. M. (2004). Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biol. Psychiatry 55, 367-375. doi: 10.1016/j.biopsych.2003.10.007
    • (2004) Biol. Psychiatry , vol.55 , pp. 367-375
    • Ladd, C.O.1    Huot, R.L.2    Thrivikraman, K.V.3    Nemeroff, C.B.4    Plotsky, P.M.5
  • 39
    • 16244368475 scopus 로고    scopus 로고
    • Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling-maternal separation as neonates
    • Ladd, C. O., Thrivikraman, K. V., Huot, R. L., and Plotsky, P. M. (2005). Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling-maternal separation as neonates. Psychoneuroendocrinology 30, 520-533. doi: 10.1016/j.psyneuen.2004.12.004
    • (2005) Psychoneuroendocrinology , vol.30 , pp. 520-533
    • Ladd, C.O.1    Thrivikraman, K.V.2    Huot, R.L.3    Plotsky, P.M.4
  • 40
    • 0034076609 scopus 로고    scopus 로고
    • Emotion circuits in the brain
    • LeDoux, J. E. (2000). Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184. doi: 10.1146/annurev.neuro.23.1.155
    • (2000) Annu. Rev. Neurosci. , vol.23 , pp. 155-184
    • LeDoux, J.E.1
  • 41
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531. doi: 10.1126/science.274.5292.1527
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.-P.1    Bengel, D.2    Heils, A.3    Sabol, S.Z.4    Greenberg, B.D.5    Petri, S.6
  • 42
    • 22144473378 scopus 로고    scopus 로고
    • Developmental determinants of sensitivity and resistance to stress
    • Levine, S. (2005). Developmental determinants of sensitivity and resistance to stress. Psychoneuroendocrinology30, 939-946. doi: 10.1016/j.psyneuen.2005.03.013
    • (2005) Psychoneuroendocrinology , vol.30 , pp. 939-946
    • Levine, S.1
  • 44
    • 0242456044 scopus 로고    scopus 로고
    • Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
    • Lira, A., Zhou, M., Castanon, N., Ansorge, M. S., Gordon, J. A., Francis, J. H., et al. (2003). Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol. Psychiatry 54, 960-971. doi: 10.1016/S0006-3223(03)00696-6
    • (2003) Biol. Psychiatry , vol.54 , pp. 960-971
    • Lira, A.1    Zhou, M.2    Castanon, N.3    Ansorge, M.S.4    Gordon, J.A.5    Francis, J.H.6
  • 45
    • 15144344289 scopus 로고    scopus 로고
    • Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
    • Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., et al. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277, 1659-1662. doi: 10.1126/science.277.5332.1659
    • (1997) Science , vol.277 , pp. 1659-1662
    • Liu, D.1    Diorio, J.2    Tannenbaum, B.3    Caldji, C.4    Francis, D.5    Freedman, A.6
  • 46
    • 33750954402 scopus 로고    scopus 로고
    • Developmental plasticity of HPA and fear responses in rats: A critical review of the maternal mediation hypothesis
    • Macrì, S., and Würbel, H. (2006). Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis. Horm. Behav. 50, 667-680. doi: 10.1016/j.yhbeh.2006.06.015
    • (2006) Horm. Behav. , vol.50 , pp. 667-680
    • Macrì, S.1    Würbel, H.2
  • 47
    • 77952548291 scopus 로고    scopus 로고
    • Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment
    • Maniam, J., and Morris, M. J. (2010). Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment. Psychoneuroendocrinology 35, 717-728. doi: 10.1016/j.psyneuen.2009.10.013
    • (2010) Psychoneuroendocrinology , vol.35 , pp. 717-728
    • Maniam, J.1    Morris, M.J.2
  • 48
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    • McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12, 342-348. doi: 10.1038/nn.2270.
    • (2009) Nat. Neurosci. , vol.12 , pp. 342-348
    • McGowan, P.O.1    Sasaki, A.2    D'Alessio, A.C.3    Dymov, S.4    Labonté, B.5    Szyf, M.6
  • 49
    • 84885433816 scopus 로고    scopus 로고
    • Role of prefrontal cortex glucocorticoid receptors in stress and emotion
    • McKlveen, J. M., Myers, B., Flak, J. N., Bundzikova, J., Solomon, M. B., Seroogy, K. B., et al. (2013). Role of prefrontal cortex glucocorticoid receptors in stress and emotion. Biol. Psychiatry 74, 672-679. doi: 10.1016/j.biopsych.2013.03.024
    • (2013) Biol. Psychiatry , vol.74 , pp. 672-679
    • McKlveen, J.M.1    Myers, B.2    Flak, J.N.3    Bundzikova, J.4    Solomon, M.B.5    Seroogy, K.B.6
  • 50
    • 0034928759 scopus 로고    scopus 로고
    • Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    • Meaney, M. J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu. Rev. Neurosci. 24, 1161-1192. doi: 10.1146/annurev.neuro.24.1.1161
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1161-1192
    • Meaney, M.J.1
  • 51
    • 84873524329 scopus 로고    scopus 로고
    • Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder
    • Medina, A., Seasholtz, A. F., Sharma, V., Burke, S., Bunney, W., Myers, R. M., et al. (2013). Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder. J. Psychiatr. Res. 47, 307-314. doi: 10.1016/j.jpsychires.2012.11.002
    • (2013) J. Psychiatr. Res. , vol.47 , pp. 307-314
    • Medina, A.1    Seasholtz, A.F.2    Sharma, V.3    Burke, S.4    Bunney, W.5    Myers, R.M.6
  • 52
    • 84896105340 scopus 로고    scopus 로고
    • Glucocorticoid actions on synapses, circuits, and behavior: Implications for the energetics of stress
    • Myers, B., McKlveen, J. M., and Herman, J. P. (2014). Glucocorticoid actions on synapses, circuits, and behavior: implications for the energetics of stress. Front. Neuroendocrinol. 35, 180-196. doi: 10.1016/j.yfrne.2013.12.003
    • (2014) Front. Neuroendocrinol. , vol.35 , pp. 180-196
    • Myers, B.1    McKlveen, J.M.2    Herman, J.P.3
  • 53
    • 79960782040 scopus 로고    scopus 로고
    • Social defeat: Impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice
    • Narayanan, V., Heiming, R. S., Jansen, F., Lesting, J., Sachser, N., Pape, H.-C., et al. (2011). Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice. PLoS ONE 6:e22600. doi: 10.1371/journal.pone.0022600
    • (2011) PLoS ONE , vol.6
    • Narayanan, V.1    Heiming, R.S.2    Jansen, F.3    Lesting, J.4    Sachser, N.5    Pape, H.-C.6
  • 54
    • 84862502708 scopus 로고    scopus 로고
    • Mismatch or cumulative stress: Toward an integrated hypothesis of programming effects
    • Nederhof, E., and Schmidt, M. V. (2012). Mismatch or cumulative stress: toward an integrated hypothesis of programming effects. Physiol. Behav. 106, 691-700. doi: 10.1016/j.physbeh.2011.12.008
    • (2012) Physiol. Behav. , vol.106 , pp. 691-700
    • Nederhof, E.1    Schmidt, M.V.2
  • 55
    • 84862611550 scopus 로고    scopus 로고
    • Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats
    • Nonkes, L. J. P., De Pooter, M., and Homberg, J. R. (2012). Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats. J. Psychiatry Neurosci. 37, 224-230. doi: 10.1503/jpn.110116
    • (2012) J. Psychiatry Neurosci. , vol.37 , pp. 224-230
    • Nonkes, L.J.P.1    De Pooter, M.2    Homberg, J.R.3
  • 56
    • 0026532055 scopus 로고
    • Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning
    • Oitzl, M. S., and De Kloet, E. R. (1992). Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behav. Neurosci. 106, 62-71. doi: 10.1037/0735-7044.106.1.62
    • (1992) Behav. Neurosci. , vol.106 , pp. 62-71
    • Oitzl, M.S.1    De Kloet, E.R.2
  • 57
    • 40949084721 scopus 로고    scopus 로고
    • A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders
    • Olivier, J. D. A., Van der Hart, M. G. C., Van Swelm, R. P. L., Dederen, P. J., Homberg, J. R., Cremers, T., et al. (2008). A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience 152, 573-584. doi: 10.1016/j.neuroscience.2007.12.032
    • (2008) Neuroscience , vol.152 , pp. 573-584
    • Olivier, J.D.A.1    Van der Hart, M.G.C.2    Van Swelm, R.P.L.3    Dederen, P.J.4    Homberg, J.R.5    Cremers, T.6
  • 58
    • 0035280252 scopus 로고    scopus 로고
    • Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment
    • Pariante, C. M., and Miller, A. H. (2001). Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49, 391-404. doi: 10.1016/S0006-3223(00)01088-X
    • (2001) Biol. Psychiatry , vol.49 , pp. 391-404
    • Pariante, C.M.1    Miller, A.H.2
  • 59
    • 0027195888 scopus 로고
    • Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
    • Plotsky, P. M., and Meaney, M. J. (1993). Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Res. Mol. Brain Res. 18, 195-200. doi: 10.1016/0169-328X(93)90189-V
    • (1993) Brain Res. Mol. Brain Res. , vol.18 , pp. 195-200
    • Plotsky, P.M.1    Meaney, M.J.2
  • 60
    • 27744501266 scopus 로고    scopus 로고
    • Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring
    • Plotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., and Meaney, M. J. (2005). Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology 30, 2192-2204. doi: 10.1038/sj.npp.1300769
    • (2005) Neuropsychopharmacology , vol.30 , pp. 2192-2204
    • Plotsky, P.M.1    Thrivikraman, K.V.2    Nemeroff, C.B.3    Caldji, C.4    Sharma, S.5    Meaney, M.J.6
  • 61
    • 84877026896 scopus 로고    scopus 로고
    • Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients
    • Qi, X.-R., Kamphuis, W., Wang, S., Wang, Q., Lucassen, P. J., Zhou, J.-N., et al. (2013). Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients. Psychoneuroendocrinology 38, 863-870. doi: 10.1016/j.psyneuen.2012.09.014
    • (2013) Psychoneuroendocrinology , vol.38 , pp. 863-870
    • Qi, X.-R.1    Kamphuis, W.2    Wang, S.3    Wang, Q.4    Lucassen, P.J.5    Zhou, J.-N.6
  • 62
    • 84883315917 scopus 로고    scopus 로고
    • Chronic stress-induced alterations of dendritic spine subtypes predict functional decrements in an hypothalamo-pituitary-adrenal-inhibitory prefrontal circuit
    • Radley, J. J., Anderson, R. M., Hamilton, B. A., Alcock, J. A., and Romig-Martin, S. A. (2013). Chronic stress-induced alterations of dendritic spine subtypes predict functional decrements in an hypothalamo-pituitary-adrenal-inhibitory prefrontal circuit. J. Neurosci. 33, 14379-14391. doi: 10.1523/JNEUROSCI.0287-13.2013
    • (2013) J. Neurosci. , vol.33 , pp. 14379-14391
    • Radley, J.J.1    Anderson, R.M.2    Hamilton, B.A.3    Alcock, J.A.4    Romig-Martin, S.A.5
  • 63
    • 77951494204 scopus 로고    scopus 로고
    • Gender-dependent effects of early maternal separation and variable chronic stress on vasopressinergic activity and glucocorticoid receptor expression in adult rats
    • Renard, G. M., Rivarola, M. A., and Suárez, M. M. (2010). Gender-dependent effects of early maternal separation and variable chronic stress on vasopressinergic activity and glucocorticoid receptor expression in adult rats. Dev. Neurosci. 32, 71-80. doi: 10.1159/000280102
    • (2010) Dev. Neurosci. , vol.32 , pp. 71-80
    • Renard, G.M.1    Rivarola, M.A.2    Suárez, M.M.3
  • 64
    • 67649206975 scopus 로고    scopus 로고
    • Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression
    • Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression. JAMA 301, 2462-2471. doi: 10.1001/jama.2009.878
    • (2009) JAMA , vol.301 , pp. 2462-2471
    • Risch, N.1    Herrell, R.2    Lehner, T.3    Liang, K.-Y.4    Eaves, L.5    Hoh, J.6
  • 65
    • 0031050555 scopus 로고    scopus 로고
    • Basolateral amygdala lesions block the memory-enhancing effect of glucocorticoid administration in the dorsal hippocampus of rats
    • Roozendaal, B., and McGaugh, J. L. (1997). Basolateral amygdala lesions block the memory-enhancing effect of glucocorticoid administration in the dorsal hippocampus of rats. Eur. J. Neurosci. 9, 76-83. doi: 10.1111/j.1460-9568.1997.tb01355.x
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 76-83
    • Roozendaal, B.1    McGaugh, J.L.2
  • 67
    • 79955948146 scopus 로고    scopus 로고
    • Serotonin transporter genotype x construction stress interaction in rats
    • Schipper, P., Nonkes, L. J. P., Karel, P., Kiliaan, A. J., and Homberg, J. R. (2011). Serotonin transporter genotype x construction stress interaction in rats. Behav. Brain Res. 223, 169-175. doi: 10.1016/j.bbr.2011.04.037
    • (2011) Behav. Brain Res. , vol.223 , pp. 169-175
    • Schipper, P.1    Nonkes, L.J.P.2    Karel, P.3    Kiliaan, A.J.4    Homberg, J.R.5
  • 68
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative CT method
    • Schmittgen, T. D., and Livak, K. J. (2008). Analyzing real-time PCR data by the comparative CT method. Nat. Protoc. 3, 1101-1108. doi: 10.1038/nprot.2008.73
    • (2008) Nat. Protoc. , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 69
    • 77953356562 scopus 로고    scopus 로고
    • Corticosteroids operate as a switch between memory systems
    • Schwabe, L., Schächinger, H., De Kloet, E. R., and Oitzl, M. S. (2009). Corticosteroids operate as a switch between memory systems. J. Cogn. Neurosci. 22, 1362-1372. doi: 10.1162/jocn.2009.21278
    • (2009) J. Cogn. Neurosci. , vol.22 , pp. 1362-1372
    • Schwabe, L.1    Schächinger, H.2    De Kloet, E.R.3    Oitzl, M.S.4
  • 70
    • 33644601589 scopus 로고    scopus 로고
    • Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis
    • Smits, B. M. G., Mudde, J. B., Van de Belt, J., Verheul, M., Olivier, J., Homberg, J. R., et al. (2006). Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet. Genomics 16, 159-169. doi: 10.1097/01.fpc.0000184960.82903.8f
    • (2006) Pharmacogenet. Genomics , vol.16 , pp. 159-169
    • Smits, B.M.G.1    Mudde, J.B.2    Van de Belt, J.3    Verheul, M.4    Olivier, J.5    Homberg, J.R.6
  • 71
    • 77952544115 scopus 로고    scopus 로고
    • Prefrontal control of fear: More than just extinction
    • Sotres-Bayon, F., and Quirk, G. J. (2010). Prefrontal control of fear: more than just extinction. Curr. Opin. Neurobiol. 20, 231-235. doi: 10.1016/j.conb.2010.02.005
    • (2010) Curr. Opin. Neurobiol. , vol.20 , pp. 231-235
    • Sotres-Bayon, F.1    Quirk, G.J.2
  • 72
    • 84885234502 scopus 로고    scopus 로고
    • Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes
    • Teicher, M. H., and Samson, J. A. (2013). Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. Am. J. Psychiatry 170, 1114-1133. doi: 10.1176/appi.ajp.2013.12070957
    • (2013) Am. J. Psychiatry , vol.170 , pp. 1114-1133
    • Teicher, M.H.1    Samson, J.A.2
  • 73
    • 67349121577 scopus 로고    scopus 로고
    • Neural regulation of endocrine and autonomic stress responses
    • Ulrich-Lai, Y. M., and Herman, J. P. (2009). Neural regulation of endocrine and autonomic stress responses. Nat. Rev. Neurosci. 10, 397-409. doi: 10.1038/nrn2647
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 397-409
    • Ulrich-Lai, Y.M.1    Herman, J.P.2
  • 74
  • 75
    • 84928011808 scopus 로고    scopus 로고
    • Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis
    • van der Doelen, R. H. A., Deschamps, W., D'Annibale, C., Peeters, D., Wevers, R. A., Zelena, D., et al. (2014). Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis. Transl. Psychiatry 4:e409. doi: 10.1038/tp.2014.57
    • (2014) Transl. Psychiatry , vol.4
    • van der Doelen, R.H.A.1    Deschamps, W.2    D'Annibale, C.3    Peeters, D.4    Wevers, R.A.5    Zelena, D.6
  • 76
    • 84888291581 scopus 로고    scopus 로고
    • Adaptive fitness; early life adversity improves adult stress coping in heterozygous serotonin transporter knockout rats
    • van der Doelen, R. H. A., Kozicz, T., and Homberg, J. R. (2013). Adaptive fitness; early life adversity improves adult stress coping in heterozygous serotonin transporter knockout rats. Mol. Psychiatry 18, 1244-1245. doi: 10.1038/mp.2012.186
    • (2013) Mol. Psychiatry , vol.18 , pp. 1244-1245
    • van der Doelen, R.H.A.1    Kozicz, T.2    Homberg, J.R.3
  • 77
    • 33645339522 scopus 로고    scopus 로고
    • Polymorphisms of the glucocorticoid receptor gene and major depression
    • van Rossum, E. F. C., Binder, E. B., Majer, M., Koper, J. W., Ising, M., Modell, S., et al. (2006). Polymorphisms of the glucocorticoid receptor gene and major depression. Biol. Psychiatry 59, 681-688. doi: 10.1016/j.biopsych.2006.02.007
    • (2006) Biol. Psychiatry , vol.59 , pp. 681-688
    • van Rossum, E.F.C.1    Binder, E.B.2    Majer, M.3    Koper, J.W.4    Ising, M.5    Modell, S.6
  • 78
    • 84871382267 scopus 로고    scopus 로고
    • Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment
    • Vivinetto, A. L., Suárez, M. M., and Rivarola, M. A. (2013). Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment. Behav. Brain Res. 240, 110-118. doi: 10.1016/j.bbr.2012.11.014
    • (2013) Behav. Brain Res. , vol.240 , pp. 110-118
    • Vivinetto, A.L.1    Suárez, M.M.2    Rivarola, M.A.3
  • 79
    • 84872831993 scopus 로고    scopus 로고
    • Stress induced hippocampal mineralocorticoid and estrogen receptor β gene expression and long-term potentiation in male adult rats is sensitive to early-life stress experience
    • Wang, H., Meyer, K., and Korz, V. (2013). Stress induced hippocampal mineralocorticoid and estrogen receptor β gene expression and long-term potentiation in male adult rats is sensitive to early-life stress experience. Psychoneuroendocrinology 38, 250-262. doi: 10.1016/j.psyneuen.2012.06.004
    • (2013) Psychoneuroendocrinology , vol.38 , pp. 250-262
    • Wang, H.1    Meyer, K.2    Korz, V.3
  • 81
    • 0036428858 scopus 로고    scopus 로고
    • Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders
    • Webster, M., Knable, M., O'Grady, J., Orthmann, J., and Weickert, C. (2002). Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol. Psychiatry 7, 985-994. doi: 10.1038/sj.mp.4001139
    • (2002) Mol. Psychiatry , vol.7 , pp. 985-994
    • Webster, M.1    Knable, M.2    O'Grady, J.3    Orthmann, J.4    Weickert, C.5
  • 82
    • 33846448741 scopus 로고    scopus 로고
    • Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice
    • Wellman, C. L., Izquierdo, A., Garrett, J. E., Martin, K. P., Carroll, J., Millstein, R., et al. (2007). Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J. Neurosci. 27, 684-691. doi: 10.1523/JNEUROSCI.4595-06.2007
    • (2007) J. Neurosci. , vol.27 , pp. 684-691
    • Wellman, C.L.1    Izquierdo, A.2    Garrett, J.E.3    Martin, K.P.4    Carroll, J.5    Millstein, R.6
  • 83
    • 70449413781 scopus 로고    scopus 로고
    • Status of glucocorticoid alterations in post-traumatic stress disorder
    • Yehuda, R. (2009). Status of glucocorticoid alterations in post-traumatic stress disorder. Ann. N.Y. Acad. Sci. 1179, 56-69. doi: 10.1111/j.1749-6632.2009.04979.x
    • (2009) Ann. N.Y. Acad. Sci. , vol.1179 , pp. 56-69
    • Yehuda, R.1


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