A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females

Translational Psychiatry

Volumn 1, Issue , 2011, Pages

  Klok, M D ^a   Giltay, E J ^b   Van Der Does, A J W ^b,c   Geleijnse, J M ^d   Antypa, N ^c   Penninx, B W J H ^e   De Geus, E J C ^f   Willemsen, G ^f   Boomsma, D I ^f   Van Leeuwen, N ^b   Zitman, F G ^b   De Kloet, E R ^a   DeRijk, R H ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

cortisol; depression; female prevalence; mineralocorticoid receptor; optimism; single nucleotide polymorphisms

Indexed keywords

MINERALOCORTICOID RECEPTOR;

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; DEPRESSION; FEMALE; GENETIC ASSOCIATION; GENETICS; HAPLOTYPE; HUMAN; MALE; MIDDLE AGED; PERSONALITY; PSYCHOLOGICAL RATING SCALE; RISK; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; DEPRESSIVE DISORDER; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; PERSONALITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, MINERALOCORTICOID; RISK; SEX FACTORS; YOUNG ADULT;

EID: 83755170516     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2011.59     Document Type: Article

References (56)

1. de Kloet ER, Joels M, Holsboer F. Stress and the brain: From adaptation to disease. Nat Rev Neurosci 2005; 6: 463-475. (Pubitemid 40769171)
2. Joels M, Karst H, DeRijk R, de Kloet ER. The coming out of the brain mineralocorticoid receptor. Trends Neurosci 2008; 31: 1-7.
3. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000; 23: 477-501.
4. DeBattista C, Belanoff J, Glass S, Khan A, Horne RL, Blasey C et al. Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression. Biol Psychiatry 2006; 60: 1343-1349. (Pubitemid 44838535)
5. Holsboer F. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J Psychiatr Res 1999; 33: 181-214. (Pubitemid 29178663)
6. Klok MD, Alt SR, Irurzun Lafitte AJM, Turner JD, Lakke EAJF, Muller CP et al. Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder. J Psychiatr Res 2011; 45: 871-878.
7. Otte C, Hinkelmann K, Moritz S, Yassouridis A, Jahn H, Wiedemann K et al. Modulation of the mineralocorticoid receptor as add-on treatment in depression: A randomized, doubleblind, placebo-controlled proof-of-concept study. J Psychiatr Res 2009; 44: 339-346.
8. Seckl JR, Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology 1992; 55: 621-626.
9. Zobel AW, Schulze-Rauschenbach S, von Widdern OC, Metten M, Freymann N, Grasmader K et al. Improvement of working but not declarative memory is correlated with HPA normalization during antidepressant treatment. J Psychiatr Res 2004; 38: 377-383. (Pubitemid 38760005)
10. van Leeuwen N, Bellingrath S, de Kloet ER, Zitman FG, DeRijk RH, Kudielka BM et al. Human Mineralocorticoid Receptor (MR) gene haplotypes modulate MR expression and transactivation: Implication for the stress response. Psychoneuroendocrinology 2011; 36: 699-709.
11. DeRijk RH, Wust S, Meijer OC, Zennaro MC, Federenko IS, Hellhammer DH et al. A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J Clin Endocrinol Metab 2006; 91: 5083-5089. (Pubitemid 44917354)
12. Klok MD, Vreeburg SA, Penninx BWJH, Zitman FG, de Kloet ER, DeRijk RH. Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs. Psychoneuroendocrinology 2011; 36: 484-494.
13. van Leeuwen N, Kumsta R, Entringer S, de Kloet ER, Zitman FG, DeRijk RH et al. Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone. Psychoneuroendocrinology 2010; 35: 339-349.
14. DeRijk RH, de Kloet ER, Zitman FG, van Leeuwen N. Mineralocorticoid Receptor Gene Variants as Determinants of HPA Axis Regulation and Behavior. Endocr Dev. Karger, Basel 2011; 20: 137-148.
15. Matys V, Fricke E, Geffers R, Gossling E, Haubrock M, Hehl R et al. TRANSFAC: Transcriptional regulation, from patterns to profiles. Nucleic Acids Res 2003; 31: 374-378. (Pubitemid 36150406)
16. Sandelin A, Alkema W, Engstrom P, Wasserman WW, Lenhard B. JASPAR: An openaccess database for eukaryotic transcription factor binding profiles. Nucleic Acids Res 2004; 32: D91-D94. (Pubitemid 38081611)
17. Reese MG, Eeckman FH, Kulp D, Haussler D. Improved splice site detection in Genie. J Comput Biol 1997; 4: 311-323. (Pubitemid 27355870)
18. Giltay EJ, Geleijnse JM, Zitman FG, Hoekstra T, Schouten EG. Dispositional optimism and all-cause and cardiovascular mortality in a prospective cohort of elderly dutch men and women. Arch Gen Psychiatry 2004; 61: 1126-1135. (Pubitemid 39463414)
19. Tempelman CJJ. Welbevinden bij ouderen: Konstruktie van een Meetinstrument (Wellbeing in the Elderly: Development of the Scale Subjective Well-being Older Persons; in Dutch). Doctoral Dissertation. University of Groningen: Groningen, The Netherlands, 1987.
20. Van der Does W. Cognitive reactivity to sad mood: Structure and validity of a new measure. Behav Res Ther 2002; 40: 105-120.
21. Hoekstra HA, Ormel J, de Fruyt F. NEO-PI-R Handleiding. Hogrefe Uitgevers BV: Amsterdam, The Netherlands, 2007.
22. Spinhoven P, Ormel J, Sloekers PP, Kempen GI, Speckens AE, Van Hemert AM. A validation study of the Hospital Anxiety and Depression Scale (HADS) in different groups of Dutch subjects. Psychol Med 1997; 27: 363-370. (Pubitemid 27139969)
23. Van der Does AJW, Barnhofer T, Williams JMG. The Major Depression Questionnaire (MDQ). www.dousa.nl/publications, 2003.
24. Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T et al. Genomewide association for major depressive disorder: A possible role for the presynaptic protein piccolo. Mol Psychiatry 2009; 14: 359-375.
25. Penninx BW, Beekman AT, Smit JH, Zitman FG, Nolen WA, Spinhoven P et al. The Netherlands Study of Depression and Anxiety (NESDA): Rationale, objectives and methods. Int J Methods Psychiatr Res 2008; 17: 121-140.
26. APA. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association: Washington, DC, 2001.
27. Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ et al. Netherlands Twin Register: From twins to twin families. Twin Res Hum Genet 2006; 9: 849-857. (Pubitemid 46093769)
28. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265. (Pubitemid 40202029)
29. Kuningas M, de Rijk RH, Westendorp RG, Jolles J, Slagboom PE, van Heemst D. Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology 2007; 32: 1295-1301. (Pubitemid 46788863)
30. Vazquez DM, Lopez JF, Morano MI, Kwak SP, Watson SJ, Akil H. Alpha, beta, and gamma mineralocorticoid receptor messenger ribonucleic acid splice variants: Differential expression and rapid regulation in the developing hippocampus. Endocrinology 1998; 139: 3165-3177. (Pubitemid 28512346)
31. Gesing A, Bilang-Bleuel A, Droste SK, Linthorst AC, Holsboer F, Reul JM. Psychological stress increases hippocampal mineralocorticoid receptor levels: Involvement of corticotropin-releasing hormone. J Neurosci 2001; 21: 4822-4829. (Pubitemid 32565640)
32. Macleod MR, Johansson IM, Soderstrom I, Lai M, Gido G, Wieloch T et al. Mineralocorticoid receptor expression and increased survival following neuronal injury. Eur J Neurosci 2003; 17: 1549-1555. (Pubitemid 36628123)
33. Topic B, Oitzl MS, Meijer OC, Huston JP, de Souza Silva MA. Differential susceptibility to extinction-induced despair and age-dependent alterations in the hypothalamicpituitary-adrenal axis and neurochemical parameters. Neuropsychobiology 2008; 58: 138-153.
34. Schmidt M, Enthoven L, van Woezik JH, Levine S, de Kloet ER, Oitzl MS. The dynamics of the hypothalamic-pituitary-adrenal axis during maternal deprivation. J Neuroendocrinol 2004; 16: 52-57. (Pubitemid 38159393)
35. Van Eekelen JA, Oitzl MS, De Kloet ER. Adrenocortical hyporesponsiveness and glucocorticoid feedback resistance in old male brown Norway rats. J Gerontol A Biol Sci Med Sci 1995; 50: B83-B89.
36. Zennaro MC, Farman N, Bonvalet JP, Lombes M. Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states. J Clin Endocrinol Metab 1997; 82: 1345-1352. (Pubitemid 27200399)
37. Kang P, Rogalska J, Walker CA, Burke M, Seckl JR, Macleod MR et al. Injury-induced mineralocorticoid receptor expression involves differential promoter usage: A novel role for the rat MRbeta variant. Mol Cell Endocrinol 2009; 305: 56-62.
38. Zennaro MC, Le Menuet D, Lombes M. Characterization of the human mineralocorticoid receptor gene 50-regulatory region: Evidence for differential hormonal regulation of two alternative promoters via nonclassical mechanisms. Mol Endocrinol 1996; 10: 1549-1560. (Pubitemid 26408744)
39. Kudielka BM, Kirschbaum C. Sex differences in HPA axis responses to stress: A review. Biol Psychol 2005; 69: 113-132. (Pubitemid 40299386)
40. Carey MP, Deterd CH, de Koning J, Helmerhorst F, de Kloet ER. The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat. J Endocrinol 1995; 144: 311-321.
41. Quinkler M, Meyer B, Bumke-Vogt C, Grossmann C, Gruber U, Oelkers W et al. Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor. Eur J Endocrinol 2002; 146: 789-799.
42. Seckl JR. 11beta-Hydroxysteroid dehydrogenase in the brain: A novel regulator of glucocorticoid action? Front Neuroendocrinol 1997; 18: 49-99. (Pubitemid 27045165)
43. Kendler KS, Fiske A, Gardner CO, Gatz M. Delineation of two genetic pathways to major depression. Biol Psychiatry 2009; 65: 808-811.
44. Southwick SM, Vythilingam M, Charney DS. The psychobiology of depression and resilience to stress: Implications for prevention and treatment. Annu Rev Clin Psychol 2005; 1: 255-291. (Pubitemid 43843952)
45. Antypa N, Van der Does AJW, Penninx BW. Cognitive reactivity: Investigation of a potentially treatable marker of suicide risk in depression. J Affect Disord 2010; 122: 46-52.
46. Nolen-Hoeksema S. The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. J Abnorm Psychol 2000; 109: 504-511.
47. Barnhofer T, Chittka T. Cognitive reactivity mediates the relationship between neuroticism and depression. Behav Res Ther 2010; 48: 275-281.
48. Carver CS, Scheier MF, Segerstrom SC. Optimism. Clin Psychol Rev 2010; 30: 879-889.
49. Giltay EJ, Zitman FG, Kromhout D. Dispositional optimism and the risk of depressive symptoms during 15 years of follow-up: The Zutphen Elderly Study. J Affect Disord 2006; 91: 45-52. (Pubitemid 43254637)
50. Karst H, Berger S, Erdmann G, Schutz G, Joels M. Metaplasticity of amygdalar responses to the stress hormone corticosterone. Proc Natl Acad Sci USA 2010; 107: 14449-14454.
51. Bogdan R, Perlis RH, Fagerness J, Pizzagalli DA. The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes Brain Behav 2010; 9: 658-667.
52. Otte C, Moritz S, Yassouridis A, Koop M, Madrischewski AM, Wiedemann K et al. Blockade of the mineralocorticoid receptor in healthy men: Effects on experimentally induced panic symptoms, stress hormones, and cognition. Neuropsychopharmacology 2007; 32: 232-238. (Pubitemid 44967802)
53. Oitzl MS, de Kloet ER. Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behav Neurosci 1992; 106: 62-71.
54. Brinks V, van der Mark MH, de Kloet ER, Oitzl MS. Differential MR/GR activation in mice results in emotional states beneficial or impairing for cognition. Neural Plast 2007; 2007: 90163.
55. Belsky J, Jonassaint C, Pluess M, Stanton M, Brummett B, Williams R. Vulnerability genes or plasticity genes? Mol Psychiatry 2009; 14: 746-754.
56. Bijl RV, Ravelli A, van Zessen G. Prevalence of psychiatric disorder in the general population: Results of The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Soc Psychiatry Psychiatr Epidemiol 1998; 33: 587-595. (Pubitemid 28528860)