Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis

Pharmacogenetics and Genomics

Volumn 16, Issue 3, 2006, Pages 159-169

  Smits, Bart M G ^a   Mudde, Josine B ^a   Van De Belt, Jose ^a   Verheul, Mark ^a   Olivier, Jocelien ^b   Homberg, Judith ^a   Guryev, Victor ^a   Cools, Alexander R ^b   Ellenbroek, Bart A ^b   Plasterk, Ronald H A ^a   Cuppen, Edwin ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

ENU mutagenesis; Missense mutations; Mutation discovery by high throughput resequencing; Rat disease models; Rat knockout

Indexed keywords

ANIMAL MODEL; ARTICLE; KNOCKOUT GENE; MODEL; MUTAGENESIS; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN;

ALKYLATING AGENTS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; ETHYLNITROSOUREA; FEMALE; GENETIC TECHNIQUES; GENOME; MALE; MUTAGENESIS, SITE-DIRECTED; PHARMACOGENETICS; RATS; RATS, INBRED F344;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33644601589     PISSN: 17446872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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