Polymorphisms of the glucocorticoid receptor gene and major depression

Biological Psychiatry

Volumn 59, Issue 8, 2006, Pages 681-688

  Van Rossum, Elisabeth F C ^a   Binder, Elisabeth B ^b   Majer, Matthias ^b   Koper, Jan W ^a   Ising, Marcus ^b   Modell, Sieglinde ^b   Salyakina, Daria ^b   Lamberts, Steven W J ^a   Holsboer, Florian ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Antidepressant treatment; Cognition; Depression; Glucocorticoid receptor gene; Glucocorticoid sensitivity; Polymorphism

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR;

ANALYSIS OF VARIANCE; ARTICLE; COGNITION; CONTROLLED STUDY; DEPRESSION; DNA POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QUESTIONNAIRE;

ADULT; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS; ASPARAGINE; CASE-CONTROL STUDIES; CORTICOTROPIN-RELEASING HORMONE; DEPRESSIVE DISORDER, MAJOR; DEXAMETHASONE; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYDROCORTISONE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; RECEPTORS, GLUCOCORTICOID; SERINE; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 33645339522     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.02.007     Document Type: Article

References (58)

1. N. Barden, I.S. Stec, A. Montkowski, F. Holsboer, J.M. Reul Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor Neuroendocrinology 66 1997 212 220
2. E.B. Binder, D. Salyakina, P. Lichtner, G.M. Wochnik, M. Ising, B. Putz Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment Nat Genet 36 2004 1319 1325
3. M.P. Boyle, J.A. Brewer, M. Funatsu, D.F. Wozniak, J.Z. Tsien, Y. Izumi, L.J. Muglia Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior Proc Natl Acad Sci U S A 102 2005 473 478
4. L.S. Brady, H.J. Whitfield Jr, R.J. Fox, P.W. Gold, M. Herkenham Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications J Clin Invest 87 1991 831 837
5. B.J. Carroll Dexamethasone suppression test for depression Adv Biochem Psychopharmacol 39 1984 179 188
6. E.R. de Kloet Hormones, brain and stress Endocr Regul 37 2003 51 68
7. E.R. de Kloet, M. Joels, F. Holsboer Stress and the brain From adaptation to disease Nat Rev Neurosci 6 2005 463 475
8. E.R. de Kloet, E. Vreugdenhil, M.S. Oitzl, M. Joels Brain corticosteroid receptor balance in health and disease Endocr Rev 19 1998 269 301
9. B. Devlin, K. Roeder Genomic control for association studies Biometrics 55 1999 997 1004
10. K. Erickson, W. Drevets, J. Schulkin Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states Neurosci Biobehav Rev 27 2003 233 246
11. M.L. Freedman, D. Reich, K.L. Penney, G.J. McDonald, A.A. Mignault, N. Patterson Assessing the impact of population stratification on genetic association studies Nat Genet 36 2004 388 393
12. J.F. Greden, R. Gardner, D. King, L. Grunhaus, B.J. Carroll, Z. Kronfol Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-retest reproducibility Arch Gen Psychiatry 40 1983 493 500
13. I. Heuser, A. Yassouridis, F. Holsboer The combined dexamethasone/CRH test A refined laboratory test for psychiatric disorders J Psychiatr Res 28 1994 341 356
14. I.J. Heuser, U. Schweiger, U. Gotthardt, J. Schmider, C.H. Lammers, M. Dettling Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects Am J Psychiatry 153 1996 93 99
15. F. Holsboer The corticosteroid receptor hypothesis of depression Neuropsychopharmacology 23 2000 477 501
16. F. Holsboer, R. Liebl, E. Hofschuster Repeated dexamethasone suppression test during depressive illness. Normalisation of test result compared with clinical improvement J Affect Disord 4 1982 93 101
17. N.A. Huizenga, J.W. Koper, P. De Lange, H.A. Pols, R.P. Stolk, H. Burger A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo J Clin Endocrinol Metabol 83 1998 144 151
18. M. Ising, H.E. Künzel, E.B. Binder, T. Nickel, S. Modell, F. Holsboer The combined dexamethasone/CRH test as a potential surrogate marker in depression Prog Neuropsychopharmacol Biol Psychiatry 29 2005 1085 1093
19. C. Kress, H. Thomassin, T. Grange Local DNA demethylation in vertebrates How could it be performed and targeted? FEBS Lett 494 2001 135 140
20. M. Majer, M. Ising, H.E. Künzel, E.B. Binder, F. Holsboer, S. Modell, J. Zihl Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders Psychol Med 34 2004 1453 1463
21. B.S. McEwen Effects of adverse experiences for brain structure and function Biol Psychiatry 48 2000 721 731
22. Z. Merali, L. Du, P. Hrdina, M. Palkovits, G. Faludi, M.O. Poulter, H. Anisman Dysregulation in the suicide brain mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region J Neurosci 24 2004 1478 1485
23. Z. Merali, P. Kent, L. Du, P. Hrdina, M. Palkovits, G. Faludi Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects Biol Psychiatry 59 2006 594 602
24. A. Montkowski, N. Barden, C. Wotjak, I. Stec, J. Ganster, M. Meaney Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function J Neuroendocrinol 7 1995 841 845
25. C.B. Nemeroff, M.J. Owens, G. Bissette, A.C. Andorn, M. Stanley Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims Arch Gen Psychiatry 45 1988 577 579
26. T. Nickel, A. Sonntag, J. Schill, A.W. Zobel, N. Ackl, A. Brunnauer Clinical and neurobiological effects of tianeptine and paroxetine in major depression J Clin Psychopharmacol 23 2003 155 168
27. M.J. Owen, A.G. Cardno Psychiatric genetics Progress, problems, and potential Lancet 354 suppl 1 1999 SI11 SI14
28. M. Panarelli, C.D. Holloway, R. Fraser, J.M. Connell, M.C. Ingram, N.H. Anderson, C.J. Kenyon Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects J Clin Endocrinol Metab 83 1998 1846 1852
29. C.M. Pariante, A. Hye, R. Williamson, A. Makoff, S. Lovestone, R.W. Kerwin The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones Neuropsychopharmacology 28 2003 1553 1561
30. C.M. Pariante, A. Makoff, S. Lovestone, S. Feroli, A. Heyden, A.H. Miller, R.W. Kerwin Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters Br J Pharmacol 134 2001 1335 1343
31. C.M. Pariante, A.H. Miller Glucocorticoid receptors in major depression Relevance to pathophysiology and treatment Biol Psychiatry 49 2001 391 404
32. C.M. Pariante, S.A. Thomas, S. Lovestone, A. Makoff, R.W. Kerwin Do antidepressants regulate how cortisol affects the brain? Psychoneuroendocrinology 29 2004 423 447
33. M.C. Pepin, S. Beaulieu, N. Barden Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures Brain Res Mol Brain Res 6 1989 77 83
34. M.C. Pepin, M.V. Govindan, N. Barden Increased glucocorticoid receptor gene promoter activity after antidepressant treatment Mol Pharmacol 41 1992 1016 1022
35. F.C. Raadsheer, W.J. Hoogendijk, F.C. Stam, F.J. Tilders, D.F. Swaab Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients Neuroendocrinology 60 1994 436 444
36. Q.R. Regestein, L.I. Rose, G.H. Williams Psychopathology in Cushing's syndrome Arch Intern Med 130 1972 114 117
37. J.M. Reul, F. Holsboer Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression Curr Opin Pharmacol 2 2002 23 33
38. J.M. Reul, M.S. Labeur, D.E. Grigoriadis, E.B. De Souza, F. Holsboer Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide Neuroendocrinology 60 1994 509 519
39. J.M. Reul, I. Stec, M. Soder, F. Holsboer Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system Endocrinology 133 1993 312 320
40. S. Ridder, S. Chourbaji, R. Hellweg, A. Urani, C. Zacher, W. Schmid Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions J Neurosci 25 2005 6243 6250
41. H. Russcher, E.F.C. van Rossum, F.H. de Jong, A.O. Brinkmann, S.W.J. Lamberts, J.W. Koper Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism Mol Endocrinol 19 2005 1687 1696
42. P.D. Sasieni From genotypes to genes doubling the sample size Biometrics 53 1997 1253 1261
43. J. Schulkin, P.W. Gold, B.S. McEwen Induction of corticotropin-releasing hormone gene expression by glucocorticoids Implication for understanding the states of fear and anxiety and allostatic load Psychoneuroendocrinology 23 1998 219 243
44. J.R. Seckl, G. Fink Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo Neuroendocrinology 55 1992 621 626
45. N. Sousa, O.F. Almeida Corticosteroids Sculptors of the hippocampal formation Rev Neurosci 13 2002 59 84
46. H.H. Stassen, J. Angst, A. Delini-Stula Delayed onset of action of antidepressant drugs? Survey of results of Zurich meta-analyses Pharmacopsychiatry 29 1996 87 96
47. J.V. Tavares, W.C. Drevets, B.J. Sahakian Cognition in mania and depression Psychol Med 33 2003 959 967
48. E.F.C. van Rossum, J.W. Koper, A.W. van den Beld, A.G. Uitterlinden, P. Arp, W. Ester Identification of the Bcl I polymorphism in the glucocorticoid receptor gene Association with sensitivity to glucocorticoids in vivo, and body mass index Clinical Endocrinology 59 2003 585 592
49. E.F.C. van Rossum, J.W. Koper, N.A. Huizenga, A.G. Uitterlinden, J.A. Janssen, A.O. Brinkmann A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels Diabetes 51 2002 3128 3134
50. E.F.C. van Rossum, S.W.J. Lamberts Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition Recent Prog Horm Res 59 2004 333 357
51. H. Vedder, U. Bening-Abu-Shach, S. Lanquillon, J.C. Krieg Regulation of glucocorticoid receptor-mRNA in human blood cells by amitriptyline and dexamethasone J Psychiatr Res 33 1999 303 308
52. U. von Bardeleben, F. Holsboer Effect of age on the cortisol response to human corticotropin-releasing hormone in depressed patients pretreated with dexamethasone Biol Psychiatry 29 1991 1042 1050
53. U. von Bardeleben, F. Holsboer, G.K. Stalla, O.A. Muller Combined administration of human corticotropin-releasing factor and lysine vasopressin induces cortisol escape from dexamethasone suppression in healthy subjects Life Sci 37 1985 1613 1618
54. S. Watson, P. Gallagher, D. Del-Estal, A. Hearn, I.N. Ferrier, A.H. Young Hypothalamic-pituitary-adrenal axis function in patients with chronic depression Psychol Med 32 2002 1021 1028
55. S. Wust, E.F. Van Rossum, I.S. Federenko, J.W. Koper, R. Kumsta, D.H. Hellhammer Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress J Clin Endocrinol Metab 89 2004 565 573
56. M.R. Yudt, J.A. Cidlowski Molecular identification and characterization of a and b forms of the glucocorticoid receptor Mol Endocrinol 15 2001 1093 1103
57. P. Zimmermann, R. Sprengelmeyer, B. Fimm, C.W. Wallesch Cognitive slowing in decision tasks in early and advanced Parkinson's disease Brain Cogn 18 1992 60 69
58. A.W. Zobel, T. Nickel, A. Sonntag, M. Uhr, F. Holsboer, M. Ising Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study J Psychiatr Res 35 2001 83 94