GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 18, 2014, Pages

  Hansen, Erik C ^a   Seamon, Kyle J ^a   Cravens, Shannen L ^a   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNTP induced oligomerization; Enzyme catalysis; Innate immunity

Indexed keywords

DIMER; GUANOSINE TRIPHOSPHATE; MONOMER; PARATHION; PROTEIN; STERILE ALPHA MOTIF HISTIDINE ASPARTATE DOMAIN CONTAINING PROTEIN 1; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; SEDIMENTATION RATE;

DNTP INDUCED OLIGOMERIZATION; ENZYME CATALYSIS; INNATE IMMUNITY;

CATALYTIC DOMAIN; DEOXYGUANINE NUCLEOTIDES; DEOXYGUANOSINE; DEOXYRIBONUCLEOTIDES; DEOXYURACIL NUCLEOTIDES; ENZYME ACTIVATION; GUANOSINE TRIPHOSPHATE; HIV-1; HUMANS; IMMUNITY, INNATE; KINETICS; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SUBSTRATE SPECIFICITY; THIONUCLEOSIDES;

EID: 84899804645     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1401706111     Document Type: Article

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