Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

FEBS Open Bio

Volumn 4, Issue , 2014, Pages 777-787

  Takemoto, Kenji ^a   Hatano, Etsuro ^a   Iwaisako, Keiko ^a   Takeiri, Masatoshi ^a   Noma, Naruto ^a   Ohmae, Saori ^a   Toriguchi, Kan ^a   Tanabe, Kazutaka ^a   Tanaka, Hirokazu ^a   Seo, Satoru ^a   Taura, Kojiro ^a   Machida, Keigo ^b   Takeda, Norihiko ^c   Saji, Shigehira ^a   Uemoto, Shinji ^a   Asagiri, Masataka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Acetaminophen; Acute liver failure; Hepatocytes; Necroptosis; Reactive oxygen species; RIPK dependent necrosis

Indexed keywords

CYTOCHROME P450 2E1; ENZYME INHIBITOR; GLUTATHIONE; LIVER ENZYME; NECROSTATIN 1; PARACETAMOL; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN KINASE 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL VEIN; CONTROLLED STUDY; DEPLETION; DRUG INDUCED DISEASE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; LIVER CELL; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NECROPTOSIS; NECROSIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION;

EID: 84907751865     PISSN: None     EISSN: 22115463     Source Type: Journal    
DOI: 10.1016/j.fob.2014.08.007     Document Type: Article

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