The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

Science Signaling

Volumn 3, Issue 115, 2010, Pages

  Vandenabeele, Peter ^a,b   Declercq, Wim ^a,b   Van Herreweghe, Franky ^a,b   Berghe, Tom Vanden ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; LIPOXYGENASE; OXIDOREDUCTASE; PHOSPHOLIPASE A2; PROTEIN RIP 1; PROTEIN RIP 3; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; HRB PROTEIN, HUMAN; NUCLEOPORIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, HUMAN; RNA BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN;

BIOENERGY; CALCIUM MOBILIZATION; CELL DEATH; CELL SURVIVAL; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; NECROSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; APOPTOSIS; METABOLISM; MITOCHONDRION; MOUSE; NEOPLASM; PATHOLOGY; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; CASPASES; HUMANS; MICE; MITOCHONDRIA; NECROSIS; NEOPLASMS; NUCLEAR PORE COMPLEX PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; REPERFUSION INJURY; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN;

EID: 77953672526     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3115re4     Document Type: Review

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102. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
103. Acknowledgments: We thank A. Bredan for editing and N. Takahashi for critically reading the manuscript. We apologize to the many authors whose original work could not be cited due to reference limitations. Funding: This research has been supported by VIB, Ghent University, Framework Programme 6 (FP6) ApopTrain, MRTN-CT-035624; FP6 Epistem, LSHB-CT-2005-019067; Apo-Sys FP7-200767, IAP 6/18, Research Foundation Flanders (FWO-Vlaanderen) (3G.0218.06 and G.0226.09) and Flemish Special Research Fund-Concerted Research Actions BOFGOA 12.0505.02. T. V. B. holds a grant of the FWO and P. V. holds a Methusalem grant from the Flemish Government.