The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

FASEB Journal

Volumn 28, Issue 10, 2014, Pages 4335-4346

  Zolnerciks, Joseph K ^a   Akkaya, Begum G ^a   Snippe, Marjolein ^a   Chiba, Peter ^b   Seelig, Anna ^c   Linton, Kenneth J ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

ABC transporter molecular mechanism; Drug efflux pump; MDR1; Membrane protein; Primary active transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; BORON DIPYRROMETHENE; DRUG DERIVATIVE; FLUORESCENT DYE; GLUTAMINE; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG; VERAPAMIL; ABCB1 PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BINDING;

ARTICLE; CATALYSIS; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BINDING; DRUG BINDING SITE; DRUG TRANSPORT; ENERGY TRANSFER; HEK293 CELL LINE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MULTIDRUG RESISTANCE; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN EXPRESSION; ACTIVE TRANSPORT; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEINS; POINT MUTATION; PROTEIN BINDING; VERAPAMIL;

EID: 84907683485     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-245639     Document Type: Article

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