-
1
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
Szakacs G., Paterson J.K., Ludwig J.A., Booth-Genthe C., and Gottesman M.M. Targeting multidrug resistance in cancer. Nat. Rev. 5 (2006) 219-234
-
(2006)
Nat. Rev.
, vol.5
, pp. 219-234
-
-
Szakacs, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
2
-
-
0030924052
-
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
-
Dey S., Ramachandra M., Pastan I., Gottesman M.M., and Ambudkar S.V. Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 10594-10599
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 10594-10599
-
-
Dey, S.1
Ramachandra, M.2
Pastan, I.3
Gottesman, M.M.4
Ambudkar, S.V.5
-
3
-
-
0025193531
-
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells
-
Raviv Y., Pollard H.B., Bruggemann E.P., Pastan I., and Gottesman M.M. Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. J. Biol. Chem. 265 (1990) 3975-3980
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 3975-3980
-
-
Raviv, Y.1
Pollard, H.B.2
Bruggemann, E.P.3
Pastan, I.4
Gottesman, M.M.5
-
5
-
-
0028786395
-
Both P-glycoprotein nucleotide-binding sites are catalytically active
-
Urbatsch I.L., Sankaran B., Bhagat S., and Senior A.E. Both P-glycoprotein nucleotide-binding sites are catalytically active. J. Biol. Chem. 270 (1995) 26956-26961
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26956-26961
-
-
Urbatsch, I.L.1
Sankaran, B.2
Bhagat, S.3
Senior, A.E.4
-
6
-
-
0030868612
-
Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein
-
Ambudkar S.V., Cardarelli C.O., Pashinsky I., and Stein W.D. Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. J. Biol. Chem. 272 (1997) 21160-21166
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 21160-21166
-
-
Ambudkar, S.V.1
Cardarelli, C.O.2
Pashinsky, I.3
Stein, W.D.4
-
7
-
-
0032523818
-
Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein
-
Shapiro A.B., and Ling V. Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein. Eur. J. Biochem. 254 (1998) 189-193
-
(1998)
Eur. J. Biochem.
, vol.254
, pp. 189-193
-
-
Shapiro, A.B.1
Ling, V.2
-
8
-
-
0031893374
-
Kinetics of the P-glycoprotein, the multidrug transporter
-
Stein W.D. Kinetics of the P-glycoprotein, the multidrug transporter. Exp. Physiol. 83 (1998) 221-232
-
(1998)
Exp. Physiol.
, vol.83
, pp. 221-232
-
-
Stein, W.D.1
-
9
-
-
17544365536
-
The role of passive transbilayer drug movement in multidrug resistance and its modulation
-
Eytan G.D., Regev R., Oren G., and Assaraf Y.G. The role of passive transbilayer drug movement in multidrug resistance and its modulation. J. Biol. Chem. 271 (1996) 12897-12902
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12897-12902
-
-
Eytan, G.D.1
Regev, R.2
Oren, G.3
Assaraf, Y.G.4
-
10
-
-
0035987203
-
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein
-
Hochman J.H., Yamazaki M., Ohe T., and Lin J.H. Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein. Curr. Drug. Metab. 3 (2002) 257-273
-
(2002)
Curr. Drug. Metab.
, vol.3
, pp. 257-273
-
-
Hochman, J.H.1
Yamazaki, M.2
Ohe, T.3
Lin, J.H.4
-
11
-
-
0037160075
-
A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein
-
Omote H., and Al-Shawi M.K. A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein. J. Biol. Chem. 277 (2002) 45688-45694
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45688-45694
-
-
Omote, H.1
Al-Shawi, M.K.2
-
12
-
-
14544269934
-
Inhibitors of multidrug efflux transporters: their membrane and protein interactions
-
Seelig A., and Gatlik-Landwojtowicz E. Inhibitors of multidrug efflux transporters: their membrane and protein interactions. Mini. Rev. Med. Chem. 5 (2005) 135-151
-
(2005)
Mini. Rev. Med. Chem.
, vol.5
, pp. 135-151
-
-
Seelig, A.1
Gatlik-Landwojtowicz, E.2
-
13
-
-
35348853741
-
The role of size and charge for blood-brain barrier permeation of drugs and fatty acids
-
Seelig A. The role of size and charge for blood-brain barrier permeation of drugs and fatty acids. J. Mol. Neurosci. 33 (2007) 32-41
-
(2007)
J. Mol. Neurosci.
, vol.33
, pp. 32-41
-
-
Seelig, A.1
-
14
-
-
0025003117
-
Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump
-
Horio M., Pastan I., Gottesman M.M., and Handler J.S. Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump. Biochim. Biophys. Acta 1027 (1990) 116-122
-
(1990)
Biochim. Biophys. Acta
, vol.1027
, pp. 116-122
-
-
Horio, M.1
Pastan, I.2
Gottesman, M.M.3
Handler, J.S.4
-
15
-
-
0034763005
-
Rational use of in vitro P-glycoprotein assays in drug discovery
-
Polli J.W., Wring S.A., Humphreys J.E., Huang L., Morgan J.B., Webster L.O., and Serabjit-Singh C.S. Rational use of in vitro P-glycoprotein assays in drug discovery. J. Pharmacol. Exp. Ther. 299 (2001) 620-628
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 620-628
-
-
Polli, J.W.1
Wring, S.A.2
Humphreys, J.E.3
Huang, L.4
Morgan, J.B.5
Webster, L.O.6
Serabjit-Singh, C.S.7
-
16
-
-
0037464458
-
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery
-
Schwab D., Fischer H., Tabatabaei A., Poli S., and Huwyler J. Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J. Med. Chem. 46 (2003) 1716-1725
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1716-1725
-
-
Schwab, D.1
Fischer, H.2
Tabatabaei, A.3
Poli, S.4
Huwyler, J.5
-
17
-
-
0036896304
-
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs
-
Mahar Doan K.M., Humphreys J.E., Webster L.O., Wring S.A., Shampine L.J., Serabjit-Singh C.J., Adkison K.K., and Polli J.W. Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J. Pharmacol. Exp. Ther. 303 (2002) 1029-1037
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 1029-1037
-
-
Mahar Doan, K.M.1
Humphreys, J.E.2
Webster, L.O.3
Wring, S.A.4
Shampine, L.J.5
Serabjit-Singh, C.J.6
Adkison, K.K.7
Polli, J.W.8
-
18
-
-
33749522506
-
Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity
-
Meier M., Blatter X.L., Seelig A., and Seelig J. Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity. Biophys. J. 91 (2006) 2943-2955
-
(2006)
Biophys. J.
, vol.91
, pp. 2943-2955
-
-
Meier, M.1
Blatter, X.L.2
Seelig, A.3
Seelig, J.4
-
19
-
-
1842426089
-
Towards P-glycoprotein structure-activity relationships
-
Waterbeemd v.d., and Lennernäs A. (Eds), Permeability and Absorption, Wiley/VCH, Weinheim
-
Seelig A., Landwojtowicz E., Fischer H., and Li Blatter X. Towards P-glycoprotein structure-activity relationships. In: Waterbeemd v.d., and Lennernäs A. (Eds). Drug Bioavailability/Estimation of Solubility (2003), Permeability and Absorption, Wiley/VCH, Weinheim 461-492
-
(2003)
Drug Bioavailability/Estimation of Solubility
, pp. 461-492
-
-
Seelig, A.1
Landwojtowicz, E.2
Fischer, H.3
Li Blatter, X.4
-
20
-
-
33947359030
-
P-glycoprotein kinetics measured in plasma membrane vesicles and living cells
-
Aanismaa P., and Seelig A. P-glycoprotein kinetics measured in plasma membrane vesicles and living cells. Biochemistry 46 (2007) 3394-3404
-
(2007)
Biochemistry
, vol.46
, pp. 3394-3404
-
-
Aanismaa, P.1
Seelig, A.2
-
21
-
-
33644672481
-
Quantification and characterization of P-glycoprotein-substrate interactions
-
Gatlik-Landwojtowicz E., Aanismaa P., and Seelig A. Quantification and characterization of P-glycoprotein-substrate interactions. Biochemistry 45 (2006) 3020-3032
-
(2006)
Biochemistry
, vol.45
, pp. 3020-3032
-
-
Gatlik-Landwojtowicz, E.1
Aanismaa, P.2
Seelig, A.3
-
22
-
-
70349509283
-
Detergents as intrinsic P-glycoprotein substrates and inhibitors
-
Li-Blatter X., Nervi P., and Seelig A. Detergents as intrinsic P-glycoprotein substrates and inhibitors. Biochim. Biophys. Acta 1788 (2009) 2335-2344
-
(2009)
Biochim. Biophys. Acta
, vol.1788
, pp. 2335-2344
-
-
Li-Blatter, X.1
Nervi, P.2
Seelig, A.3
-
23
-
-
0028964955
-
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters
-
Cardarelli C.O., Aksentijevich I., Pastan I., and Gottesman M.M. Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters. Cancer Res. 55 (1995) 1086-1091
-
(1995)
Cancer Res.
, vol.55
, pp. 1086-1091
-
-
Cardarelli, C.O.1
Aksentijevich, I.2
Pastan, I.3
Gottesman, M.M.4
-
24
-
-
8744247455
-
The rate of P-glycoprotein activation depends on the metabolic state of the cell
-
Gatlik-Landwojtowicz E., Aanismaa P., and Seelig A. The rate of P-glycoprotein activation depends on the metabolic state of the cell. Biochemistry 43 (2004) 14840-14851
-
(2004)
Biochemistry
, vol.43
, pp. 14840-14851
-
-
Gatlik-Landwojtowicz, E.1
Aanismaa, P.2
Seelig, A.3
-
25
-
-
0026913511
-
The cytosensor microphysiometer: biological applications of silicon technology
-
McConnell H.M., Owicki J.C., Parce J.W., Miller D.L., Baxter G.T., Wada H.G., and Pitchford S. The cytosensor microphysiometer: biological applications of silicon technology. Science 257 (1992) 1906-1912
-
(1992)
Science
, vol.257
, pp. 1906-1912
-
-
McConnell, H.M.1
Owicki, J.C.2
Parce, J.W.3
Miller, D.L.4
Baxter, G.T.5
Wada, H.G.6
Pitchford, S.7
-
26
-
-
0030791978
-
Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity
-
Litman T., Zeuthen T., Skovsgaard T., and Stein W.D. Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity. Biochim. Biophys. Acta 1361 (1997) 159-168
-
(1997)
Biochim. Biophys. Acta
, vol.1361
, pp. 159-168
-
-
Litman, T.1
Zeuthen, T.2
Skovsgaard, T.3
Stein, W.D.4
-
27
-
-
0346732289
-
Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein
-
Al-Shawi M.K., Polar M.K., Omote H., and Figler R.A. Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein. J. Biol. Chem. 278 (2003) 52629-52640
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52629-52640
-
-
Al-Shawi, M.K.1
Polar, M.K.2
Omote, H.3
Figler, R.A.4
-
29
-
-
4544240958
-
Halogenation of drugs enhances membrane binding and permeation
-
Gerebtzoff G., Li-Blatter X., Fischer H., Frentzel A., and Seelig A. Halogenation of drugs enhances membrane binding and permeation. Chembiochem 5 (2004) 676-684
-
(2004)
Chembiochem
, vol.5
, pp. 676-684
-
-
Gerebtzoff, G.1
Li-Blatter, X.2
Fischer, H.3
Frentzel, A.4
Seelig, A.5
-
30
-
-
0031695039
-
Blood-brain barrier permeation: molecular parameters governing passive diffusion
-
Fischer H., Gottschlich R., and Seelig A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J. Membr. Biol. 165 (1998) 201-211
-
(1998)
J. Membr. Biol.
, vol.165
, pp. 201-211
-
-
Fischer, H.1
Gottschlich, R.2
Seelig, A.3
-
31
-
-
33749510509
-
In silico prediction of blood-brain barrier permeation using the calculated molecular cross-sectional area as main parameter
-
Gerebtzoff G., and Seelig A. In silico prediction of blood-brain barrier permeation using the calculated molecular cross-sectional area as main parameter. J. Chem. Inf. Model. 46 (2006) 2638-2650
-
(2006)
J. Chem. Inf. Model.
, vol.46
, pp. 2638-2650
-
-
Gerebtzoff, G.1
Seelig, A.2
-
32
-
-
0033739115
-
Structure-activity relationship of P-glycoprotein substrates and modifiers
-
Seelig A., and Landwojtowicz E. Structure-activity relationship of P-glycoprotein substrates and modifiers. Eur. J. Pharm. Sci. 12 (2000) 31-40
-
(2000)
Eur. J. Pharm. Sci.
, vol.12
, pp. 31-40
-
-
Seelig, A.1
Landwojtowicz, E.2
-
33
-
-
0028831929
-
Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein
-
Urbatsch I.L., and Senior A.E. Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein. Arch. Biochem. Biophys. 316 (1995) 135-140
-
(1995)
Arch. Biochem. Biophys.
, vol.316
, pp. 135-140
-
-
Urbatsch, I.L.1
Senior, A.E.2
-
34
-
-
0023263405
-
Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers
-
Seelig A. Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers. Biochim. Biophys. Acta 899 (1987) 196-204
-
(1987)
Biochim. Biophys. Acta
, vol.899
, pp. 196-204
-
-
Seelig, A.1
-
35
-
-
0345019898
-
Permeability of lipid bilayer to anthracycline derivatives. Role of the bilayer composition and of the temperature
-
Frézard F., and Garnier-Suillerot A. Permeability of lipid bilayer to anthracycline derivatives. Role of the bilayer composition and of the temperature. Biochim. Biophys. Acta 1389 (1998) 13-22
-
(1998)
Biochim. Biophys. Acta
, vol.1389
, pp. 13-22
-
-
Frézard, F.1
Garnier-Suillerot, A.2
-
36
-
-
0023940909
-
Influences of solvent on group transfer potentials and biochemical recognition of carbohydrates. Anomalous solvation of the anomeric hydroxyl group
-
Wolfenden R., and Liang Y.L. Influences of solvent on group transfer potentials and biochemical recognition of carbohydrates. Anomalous solvation of the anomeric hydroxyl group. J. Biol. Chem. 263 (1988) 8022-8026
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 8022-8026
-
-
Wolfenden, R.1
Liang, Y.L.2
-
37
-
-
33947476169
-
Structure and partition coefficient. Synthesis and properties of dodecyl methyl pentaerythrityl ethers
-
Berry J.S. Structure and partition coefficient. Synthesis and properties of dodecyl methyl pentaerythrityl ethers. J. Org. Chem. 25 (1960) 1272-1274
-
(1960)
J. Org. Chem.
, vol.25
, pp. 1272-1274
-
-
Berry, J.S.1
-
38
-
-
0030043562
-
Surface areas and packing constraints in POPC C (12)EO (n) membranes. A time-resolved fluorescence study
-
Lantzch G., Binder H., Heerklotz H., Wendling M., and Klose G. Surface areas and packing constraints in POPC C (12)EO (n) membranes. A time-resolved fluorescence study. Biophys. Chem. 58 (1996) 289-302
-
(1996)
Biophys. Chem.
, vol.58
, pp. 289-302
-
-
Lantzch, G.1
Binder, H.2
Heerklotz, H.3
Wendling, M.4
Klose, G.5
-
39
-
-
0035682157
-
The mechanism of action of multidrug-resistance-linked P-glycoprotein
-
Sauna Z.E., Smith M.M., Muller M., Kerr K.M., and Ambudkar S.V. The mechanism of action of multidrug-resistance-linked P-glycoprotein. J. Bioenerg. Biomembr. 33 (2001) 481-491
-
(2001)
J. Bioenerg. Biomembr.
, vol.33
, pp. 481-491
-
-
Sauna, Z.E.1
Smith, M.M.2
Muller, M.3
Kerr, K.M.4
Ambudkar, S.V.5
-
40
-
-
0037180390
-
Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1)
-
Sauna Z.E., Muller M., Peng X.H., and Ambudkar S.V. Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1). Biochemistry 41 (2002) 13989-14000
-
(2002)
Biochemistry
, vol.41
, pp. 13989-14000
-
-
Sauna, Z.E.1
Muller, M.2
Peng, X.H.3
Ambudkar, S.V.4
-
41
-
-
39749084704
-
Development of inhibitors of ATP-binding cassette drug transporters: present status and challenges
-
Shukla S., Wu C.P., and Ambudkar S.V. Development of inhibitors of ATP-binding cassette drug transporters: present status and challenges. Expert Opin. Drug Metab. Toxicol. 4 (2008) 205-223
-
(2008)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, pp. 205-223
-
-
Shukla, S.1
Wu, C.P.2
Ambudkar, S.V.3
-
42
-
-
52249103044
-
P-glycoprotein senses its substrates and the lateral membrane packing density: consequences for the catalytic cycle
-
Aanismaa P., Gatlik-Landwojtowicz E., and Seelig A. P-glycoprotein senses its substrates and the lateral membrane packing density: consequences for the catalytic cycle. Biochemistry 47 (2008) 10197-10207
-
(2008)
Biochemistry
, vol.47
, pp. 10197-10207
-
-
Aanismaa, P.1
Gatlik-Landwojtowicz, E.2
Seelig, A.3
-
43
-
-
0141764821
-
Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery
-
Reza M.S., Quadir M.A., and Haider S.S. Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery. J. Pharm. Pharm. Sci. 6 (2003) 282-291
-
(2003)
J. Pharm. Pharm. Sci.
, vol.6
, pp. 282-291
-
-
Reza, M.S.1
Quadir, M.A.2
Haider, S.S.3
|