Pore-exposed tyrosine residues of p-glycoprotein are important hydrogen-bonding partners for drugs

Molecular Pharmacology

Volumn 85, Issue 3, 2014, Pages 420-428

  Cakil, Yaprak Dönmez ^a,b   Khunweeraphong, Narakorn ^a   Parveen, Zahida ^a,e   Schmid, Diethart ^c   Artaker, Matthias ^d   Ecker, Gerhard F ^f   Sitte, Harald H ^b   Pusch, Oliver ^b   Stockner, Thomas ^b   Chiba, Peter ^a  

^a Institutes of Medical Chemistry   (United Kingdom)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Department of Medical Biochemistry ^*  (India)

^d MAX F PERUTZ LABORATORIES   (Austria)

^e ABDUL WALI KHAN UNIVERSITY   (Pakistan)

^f UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN; MULTIDRUG RESISTANCE PROTEIN; PROPAFENONE; TYROSINE;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN STRUCTURE;

BINDING SITES; CELL LINE; HEK293 CELLS; HUMANS; HYDROGEN; HYDROGEN BONDING; LIGANDS; MUTATION; P-GLYCOPROTEIN; PROPAFENONE; PROTEIN STRUCTURE, TERTIARY; TYROSINE;

EID: 84894024586     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.088526     Document Type: Article

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