Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 314-331

  Qiang, Xiaoming ^a   Sang, Zhipei ^a   Yuan, Wen ^a   Li, Yan ^a   Liu, Qiang ^a   Bai, Ping ^a   Shi, Yikun ^b   Ang, Wei ^a   Tan, Zhenghuai ^b   Deng, Yong ^a  

^a SICHUAN UNIVERSITY   (China)

^b Sichuan Academy of Chinese Medicine Sciences   (China)

Author keywords

A aggregation inhibitors; Acetylcholinesterase inhibitors; Alzheimer's disease; Genistein O alkylbenzylamines; Metal chelating; Multifunctional agents

Indexed keywords

3 [4 (3 BROMOPROPOXY)PHENYL) 5 HYDROXY 7 (METHOXYMETHOXY) 4H CHROMEN 4 ONE; 3 [4 (4 BROMOBUTOXY)PHENYL] 5 HYDROXY 7 (METHOXYMETHOXY) 4H CHROMEN 4 ONE; 3 [4 [(6 BROMOHEXYL)OXY]PHENYL] 5 HYDROXY 7 (METHOXYMETHOXY) 4H CHROMEN 4 ONE; 3 [4 [3 (BENZYL(METHYL)AMINO]PROPOXY]PHENYL] 5 HYDROXY 7 (METHOXYMETHOXY) 4H CHROMEN 4 ONE; 3 [4 [3 [BENZYL(ETHYL)AMINO]PROPOXY]PHENYL] 5 HYDROXY 7 (METHOXYMETHOXY) 4H CHROMEN 4 ONE; 3 [4 [4 [ETHYL(2 METHOXYBENZYL)AMINO]BUTOXY]PHENYL] 5,7 DIHYDROXY 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (METHOXYMETHOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 [3 [(2 METHOXYBENZYL)(METHYL)AMINO]PROPOXY] 4H CHROMEN 4 ONE; 7 (3 BROMOPROPOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (4 BROMOBUTOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [(6 BROMOHEXYL)OXY] 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [3 (BENZYL(ETHYL)AMINO]PROPOXY] 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [3 [BENZYL(METHYL)AMINO]PROPOXY] 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [3 [ETHYL(2 METHOXYBENZYL)AMINO]PROPOXY] 5 HYDROXY 3 (4HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [4 [BENZYL(METHYL)AMINO]BUTOXY] 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [4 [ETHYL(2 METHOXYBENZYL)AMINO]BUTOXY] 3 [4 [4 [ETHYL(2 METHOXYBENZYL)AMINO]BUTOXY]PHENYL] 5 HYDROXY 4H CHROMEN 4 ONE; 7 [4 [ETHYL(2 METHOXYBENZYL)AMINO]BUTOXY] 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [[6 [BENZYL(ETHYL)AMINO]HEXYL]OXY] 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 [[6 [BENZYL(METHYL)AMINO]HEXYL]OXY] 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BENZYLAMINE DERIVATIVE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GENISTEIN; GENISTEIN O ALKYLBENZYLAMINE DERIVATIVE; N (2 METHOXYBENZYL)METHYLAMINE; N BENZYL N METHYLNITROSAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; KINETICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PASSIVE AVOIDANCE TEST; PROTEIN AGGREGATION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; IC50; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CHOLINESTERASE INHIBITORS; DRUG DESIGN; GENISTEIN; INHIBITORY CONCENTRATION 50; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84896810378     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.045     Document Type: Article

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