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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6498-6502

Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease

(15) Chao, Xiaojuan a He, Xixin b Yang, Yilin a Zhou, Xie a Jin, Minghua a Liu, Shu c Cheng, Zhiyi a Liu, Peiqing a Wang, Yuting a Yu, Jianchen a Tan, Yi b Huang, Yingjuan a Qin, Jian a Rapposelli, Simona d Pi, Rongbiao a

a SUN YAT SEN UNIVERSITY (China)

b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE (China)

c SUN YAT SEN UNIVERSITY (China)

d UNIVERSITY OF PISA (Italy)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Antioxidants; Caffeic acid; Dimer; Multi targeted compounds

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CAFFEIC ACID; CHOLINESTERASE; GLUTAMIC ACID; HYDROGEN PEROXIDE; TACRINE; TACRINE CAFFEIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL PROTECTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; IC 50; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BUTYRYLCHOLINESTERASE; CAFFEIC ACIDS; CELL DEATH; CELL LINE; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HYDROGEN PEROXIDE; MICE; NEURONS; NEUROPROTECTIVE AGENTS; TACRINE;

EID: 84866739989 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.08.036 Document Type: Article

Times cited : (103)

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