Crystal structures of human cholinesterases in complex with huprine W and tacrine: Elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Biochemical Journal

Volumn 453, Issue 3, 2013, Pages 393-399

  Nachon, Florian ^a   Carletti, Eugénie ^a   Ronco, Cyril ^b   Trovaslet, Marie ^a   Nicolet, Yvain ^c   Jean, Ludovic ^b   Renard, Pierre Yves ^b  

^a INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^b UNIVERSITÉ DE ROUEN   (France)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Huprine; Inhibitor; Tacrine; X ray structure

Indexed keywords

ACETYLCHOLINESTERASE; CARBONYL DERIVATIVE; CHLORINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; FASCICULIN; HISTIDINE; HUPRINE W; HYDROGEN; HYDROXYL GROUP; ISOQUINOLINE; SERINE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME SPECIFICITY; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINOQUINOLINES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; TACRINE;

EID: 84880070992     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130013     Document Type: Article

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