Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2905-2909

  Fang, Lei ^a,b   Kraus, Birgit ^c   Lehmann, Jochen ^a   Heilmann, Joerg ^c   Zhang, Yihua ^b   Decker, Michael ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Anti Alzheimer drug; Antioxidant; Cholinesterase inhibitor; Ferulic acid; Hybrid molecule; Tacrine

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; FERULIC ACID PLUS TACRINE; REACTIVE OXYGEN METABOLITE; TROLOX C;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLINESTERASE INHIBITION; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANTIOXIDANTS; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHROMANS; COUMARIC ACIDS; DRUG DESIGN; HUMANS; MODELS, CHEMICAL; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 42949132291     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.073     Document Type: Article

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