Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 21-30

  Thiratmatrakul, Supatra ^a   Yenjai, Chavi ^b   Waiwut, Pornthip ^c   Vajragupta, Opa ^d   Reubroycharoen, Prasert ^e   Tohda, Michihisa ^f   Boonyarat, Chantana ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

^b Khon Kaen University   (Thailand)

^c UBON RATCHATHANI UNIVERSITY   (Thailand)

^d MAHIDOL UNIVERSITY   (Thailand)

^e CHULALONGKORN UNIVERSITY   (Thailand)

^f UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Alzheimer's disease; Antioxidant; Carbazole; Cholinesterase; Molecular modeling; Tacrine

Indexed keywords

2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CARBAZOLE DERIVATIVE; CHOLINESTERASE; N1 (7 METHOXYHEPTAPHILLINE) N4 (1,2,3,4 TETRAHYDROACRIDINE 9 YL)PROPANE 1,3 DIAMINE; N1 (7 METHOXYHEPTAPHILLINE) N6 (1,2,3,4 TETRAHYDROACRIDINE 9 YL)PENTANE 1,5 DIAMINE; N1 (HEPTAPHILLINE) N6 (1,2,3,4 TETRAHYDROACRIDINE 9 YL)PROPANE 1,5 DIAMINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; LONG TERM MEMORY; MOLECULAR MODEL; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS;

ALZHEIMER'S DISEASE; ANTIOXIDANT; CARBAZOLE; CHOLINESTERASE; MOLECULAR MODELING; TACRINE;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BUTYRYLCHOLINESTERASE; CARBAZOLES; CELL LINE; CHOLINESTERASE INHIBITORS; ELECTROPHORUS; HUMANS; MALE; MEMORY DISORDERS; MICE; MOLECULAR DOCKING SIMULATION; OXIDATIVE STRESS; TACRINE;

EID: 84893731184     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.020     Document Type: Article

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