Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 21, 2012, Pages 6513-6522

  Wang, Yue ^a   Wang, Fang ^a,c   Yu, Jun Ping ^b   Jiang, Feng Chao ^a   Guan, Xin Lei ^a   Wang, Can Ming ^a   Li, Lei ^a   Cao, Hui ^a   Li, Ming Xing ^a   Chen, Jian Guo ^a,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN INSTITUTE OF VIROLOGY   (China)

^c Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province   (China)

Author keywords

Amyloid aggregation; Alzheimer's disease; Ca2+ overload; Cholinesterase inhibition; Phenylthiazole tacrine hybrids

Indexed keywords

2 (ETHYL (3 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYL)AMINO) N (4 (4 METHOXYPHENYL)THIAZOL 2 YL)ACETAMIDE; 2 (ETHYL (3 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYL)AMINO) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 (ETHYL (4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL)AMINO) N (4 (4 METHOXYPHENYL)THIAZOL 2 YL)ACETAMIDE; 2 (ETHYL (4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL)AMINO) N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 CHLORO N (4 (4 CHLOROPHENYL)THIAZOL 2 YL)PROPANAMIDE; 2 CHLORO N (4 (4 METHOXYPHENYL)THIAZOL 2 YL)ACETAMIDE; 2 CHLORO N (4 (4 METHOXYPHENYL)THIAZOL 2 YL)PROPANAMIDE; 2 CHLORO N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 3 BROMO N (4 (4 CHLOROPHENYL)THIAZOL 2 YL)PROPANAMIDE; 3 BROMO N (4 (4 METHOXYPHENYL)THIAZOL 2 YL)PROPANAMIDE; 3 BROMO N (4 PHENYLTHIAZOL 2 YL)PROPANAMIDE; 4 (4 (4 CHLOROPHENYL)THIAZOL 2 YLAMINO) 4 OXOBUTANOIC ACID; 4 OXO 4 (4 PHENYLTHIAZOL 2 YLAMINO)BUTANOIC ACID; 4 OXO 4 (4,5,6,7 TETRAHYDROBENZO[D]THIAZOL 2 YLAMINO)BUTANOIC ACID; 5 OXO 5 (4 PHENYLTHIAZOL 2 YLAMINO)PENTANOIC ACID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CHOLINESTERASE; N (4 (4 CHLOROPHENYL)THIAZOL 2 YL) 2 (ETHYL (4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL)AMINO)ACETAMIDE; N 1 (4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL) N 4 (4,5,6,7 TETRAHYDROBENZO[D]THIAZOL 2 YL)SUCCINAMIDE; N 1 (4 (4 CHLOROPHENYL)THIAZOL 2 YL) N (4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL)SUCCINAMIDE; N 1 (4 PHENYLTHIAZOL 2 YL) N 4 (4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL)SUCCINAMIDE; N 1 (4 PHENYLTHIAZOL 2 YL) N 4 (6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL)SUCCINAMIDE; N 1 (4 PHENYLTHIAZOL 2 YL) N 5 (3 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYL)GLUTARAMIDE; N 1 (4 PHENYLTHIAZOL 2 YL) N 5 (4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL)GLUTARAMIDE; NIFEDIPINE; PHENYLTHIAZOLE DERIVATIVE; TACRINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; BRAIN CELL; CALCIUM CELL LEVEL; CALCIUM OVERLOAD; CALCIUM SIGNALING; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; NEWBORN; NONHUMAN; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

AMYLOID BETA-PEPTIDES; ANIMALS; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE; THIAZOLES;

EID: 84867574520     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.040     Document Type: Article

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