Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4312-4315

  Bolognesi, Maria Laura ^a   Bartolini, Manuela ^a   Rosini, Michela ^a   Andrisano, Vincenza ^a   Melchiorre, Carlo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Amyloid beta; Butyrylcholinesterase; Small molecule protein protein interaction inhibitors

Indexed keywords

2,5 DIMETHOXYBENZOQUINONE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; BENZYLAMINE; BETA SECRETASE; MEMOQUIN; METHYL GROUP; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN AGGREGATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ACETYLCHOLINESTERASE; ALKANES; ALZHEIMER DISEASE; AMINES; AMYLOID BETA-PEPTIDES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; POLYAMINES; QUINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649996688     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.087     Document Type: Article

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