Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3- carbonitriles

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 122-133

  Samadi, Abdelouahid ^a   Valderas, Carolina ^a   Ríos, Cristóbal De Los ^b,c   Bastida, Agatha ^a   Chioua, Mourad ^a   González Lafuente, Laura ^b   Colmena, Inés ^b   Gandía, Luis ^b   Romero, Alejandro ^b   Barrio, Laura Del ^b   Martín De Saavedra, María D ^b   López, Manuela G ^b   Villarroya, Mercedes ^b   Marco Contelles, José ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

2 Aminopyridin 3 carbonitriles; AChE; Alzheimer's disease; BuChE; Inhibition mechanism; Molecular modelling; Neuronal cerebrovascular diseases; Neuroprotection; Tacrine analogues

Indexed keywords

5 AMINO 2 (DIMETHYLAMINO) 4 PHENYL 6,7,8,9 TETRAHYDROBENZO[1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 (DIMETHYLAMINO) 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 (ETHYLOXY) 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 (METHYLOXY) 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 (PROP 2 YN 1 YLAMINO) 6,7,8,9 TETRAHYDROBENZO[1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 CHLORO 4 PHENYL 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 CHLORO 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 METHOXY 4 PHENYL 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 PIPERIDIN 1 YL 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 2 PYRROLIDIN 1 YL 6,7,8,9 TETRAHYDROBENZO [1,8 B]NAPHTHYRIDINE 3 CARBONITRILE; 5 AMINO 7 BENZYL 2 CHLORO 6,7,8,9 TETRAHYDROPYRIDO [2,3 B] [1,6] NAPHTHYRIDIN 3 CARBONITRILE; 5 AMINO 7 BENZYL 2 METHOXY 6,7,8,9 TETRAHYDROPYRIDO [2,3 B] [1,6] NAPHTHYRIDINE 3 CARBONITRILE; CHOLINERGIC RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL DEATH; CELL STRESS; CEREBROVASCULAR DISEASE; CHROMAFFIN CELL; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; FEMALE; HUMAN; IC 50; MOLECULAR MODEL; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS;

BOVINAE;

EID: 78650757374     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.040     Document Type: Article

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