PKA reduces the rat and human KCa3.1 current, CaM binding, and Ca2+ signaling, which requires Ser332/334 in the CaM-binding C terminus

Journal of Neuroscience

Volumn 34, Issue 40, 2014, Pages 13371-13383

  Wong, Raymond ^a,b   Schlichter, Lyanne C ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adenosine A2a receptor; Calmodulin binding; Microglia ion channels; Mutation analysis; Protein kinase A; SK channel regulation

Indexed keywords

ADENOSINE A2A RECEPTOR; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALMODULIN; CALMODULIN BINDING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PURINERGIC RECEPTOR; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; 1-ETHYL-2-BENZIMIDAZOLINONE; BENZIMIDAZOLE DERIVATIVE; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CHANNEL STIMULATING AGENT; ENZYME INHIBITOR; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNN4 PROTEIN, HUMAN; KCNN4 PROTEIN, RAT; PROTEIN BINDING; PROTEIN KINASE; SERINE;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM SIGNALING; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MALE; MICROGLIA; MUTATIONAL ANALYSIS; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP TECHNIQUE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG EFFECTS; GENETICS; MEMBRANE POTENTIAL; METABOLISM; NEWBORN; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BENZIMIDAZOLES; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CALMODULIN; CELLS, CULTURED; ENZYME INHIBITORS; FEMALE; HEK293 CELLS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MEMBRANE POTENTIALS; PROTEIN BINDING; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SERINE;

EID: 84907481680     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1008-14.2014     Document Type: Article

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