Cross-talk between Gs- and Gq-coupled pathways in regulation of interleukin-4 by A2B adenosine receptors in human mast cells

Molecular Pharmacology

Volumn 70, Issue 2, 2006, Pages 727-735

  Ryzhov, Sergey ^a   Goldstein, Anna E ^a   Biaggioni, Italo ^a   Feoktistov, Igor ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; ADENOSINE A2B RECEPTOR; ADENYLATE CYCLASE; CALCINEURIN; CALCIUM ION; CYCLOSPORIN A; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; INTERLEUKIN 4; IONOMYCIN; NUCLEAR FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CELL STIMULATION; CHELATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAST CELL; PASTEURELLA MULTOCIDA; PRIORITY JOURNAL; PROTEIN FOLDING; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); CELLS, CULTURED; FORSKOLIN; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; INTERLEUKIN-4; MAST CELLS; NFATC TRANSCRIPTION FACTORS; RECEPTOR, ADENOSINE A2B; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33746238096     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.022780     Document Type: Article

References (61)

1. Aramburu J, Yaffe MB, Lopez-Rodriguez C, Cantley LC, Hogan PG, and Rao A (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (Wash DC) 285:2129-2133.
2. Beals CR, Sheridan CM, Turck CW, Gardner P, and Crabtree GR (1997) Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science (Wash DC) 275:1930-1934.
3. Blackburn MR, Lee CG, Young HW, Zhu Z, Chunn JL, Kang MJ, Banerjee SK, and Elias JA (2003) Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Investig 112:332-344.
4. Boise LH, Petryniak B, Mao X, June CH, Wang CY, Lindsten T, Bravo R, Kovary K, Leiden JM, and Thompson CB (1993) The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol Cel Biol 13:1911-1919.
5. Borger P, Kauffman HF, Postma DS, and Vellenga E (1996) Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Blood 87:691-698.
6. Boss V, Talpade DJ, and Murphy TJ (1996) Induction of NFAT-mediated transcription by Gq-coupled receptors in lymphoid and non-lymphoid cells. J Biol Chem 271:10429-10432.
7. 2B adenosine receptor antagonists: recent developments. Mini-Rev Med Chem 5:1053-1060.
8. Chunn JL, Young HW, Banerjee SK, Colasurdo GN, and Blackburn MR (2001) Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol 167:4676-4685.
9. Chuvpilo S, Avots A, Berberich-Siebelt F, Glockner J, Fischer C, Kerstan A, Escher C, Inashkina I, Hlubek F, Jankevics E, et al. (1999) Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes. J Immunol 162:7294-7301.
10. Driver AG, Kukoly CA, Ali S, and Mustafa SJ (1993) Adenosine in bronchoalveolar lavage fluid in asthma. Am Rev Respir Dis 148:91-97.
11. Fang X, Yu SX, Lu Y, Bast RC Jr, Woodgett JR, and Mills GB (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci USA 97:11960-11965.
12. 2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Investig 96:1979-1986.
13. 2B receptors. Pharmacol Rev 49:381-402.
14. 2B adenosine receptor subtypes. Biochem Pharmacol 55:627-633.
15. 2B receptor antagonist 3-isobutyl-8- pyrrolidinoxanthine (IPDX). Biochem Pharmacol 62:1163-1173.
16. 2B receptors in human mast cells. Drug Dev Res 58:461-471.
17. 2B receptors - a novel therapeutic target in asthma? Trends Pharmacol Sci 19:148-153.
18. 3 adenosine receptors. Circ Res 92:485-492.
19. Fozard JR (2003) The case for a role for adenosine in asthma: almost convincing? Curr Opin Pharmacol 3:264-269.
20. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz KN, and Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552.
21. Gauchat JF, Henchoz S, Mazzei G, Aubry JP, Brunner T, Blasey H, Life P, Talabot D, Flores-Romo L, and Thompson J (1993) Induction of human IgE synthesis in B cells by mast cells and basophils. Nature (Lond) 365:340-343.
22. Hains MD, Siderovski DP, and Harden TK (2004) Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. Methods Enzymol 389:71-88.
23. 2B-selective adenosine receptor antagonists. J Med Chem 45:1500-1510.
24. Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, and Blumer KJ (1999) G protein selectivity is a determinant of RGS2 function. J Biol Chem 274:34253-34259.
25. Heximer SP, Watson N, Linder ME, Blumer KJ, and Hepler JR (1997) RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proc Natl Acad Sci USA 94:14389-14393.
26. 2B receptor as a novel therapeutic target in asthma. Br J Pharmacol 145:1009-1015.
27. Huszar E, Vass G, Vizi E, Csoma Z, Barat E, Molnar VG, Herjavecz I, and Horvath I (2002) Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma. Eur Respir J 20:1393-1398.
28. 2+/calcineurin-NFAT-mediated signaling. Mol Cells 18:1-9.
29. Johnson RA, Desaubry L, Bianchi G, Shoshani I, Lyons E Jr, Taussig R, Watson PA, Cali JJ, Krupinski J, Pieroni JP, et al. (1997) Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates. J Biol Chem 272:8962-8966.
30. 2B adenosine receptors. J Med Chem 43:1165-1172.
31. + T cells while decreasing IL-2 release and NF-AT induction. Int Immunol 6:1333-1343.
32. q in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol 56:705-713.
33. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, and Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-815.
34. Li-Weber M, Salgame P, Hu C, Davydov IV, Laur O, Klevenz S, and Krammer PH (1998) Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter. J Immunol 161:1380-1389.
35. 2b receptor. Biochem Pharmacol 64:317-325.
36. Monticelli S, Solymar DC, and Rao A (2004) Role of NFAT proteins in IL13 gene transcription in mast cells. J Biol Chem 279:36210-36218.
37. Nesbitt SA and Horton MA (1992) A nonradioactive biochemical characterization of membrane proteins using enhanced chemiluminescence. Anal Biochem 206:267-272.
38. Neves SR, Ram PT, and Iyengar R (2002) G protein pathways. Science (Wash DC) 296:1636-1639.
39. Nilsson G, Blom T, Kusche-Gullberg M, Kjellen I, Butterfield JH, Sundstrom C, Nilsson K, and Hellman L (1994) Phenotypic characterization of the human mast-cell line HMC-1. Scand J Immunol 39:489-498.
40. Okayama Y, Petit-Frere C, Kassel O, Semper A, Quint D, Tunon-de-Lara MJ, Bradding P, Holgate ST, and Church MK (1995) IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells. J Immunol 155:1796-1808.
41. Plaut M, Pierce JH, Watson CJ, Hanley-Hyde J, Nordan RP, and Paul WE (1989) Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (Lond) 339:64-67.
42. Polosa R, Rorke S, and Holgate ST (2002) Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Thorax 57:649-654.
43. Pouw-Kraan T, Van Kooten C, Rensink I, and Aarden L (1992) Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production. Eur J Immunol 22:1237-1241.
44. 2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J Immunol 172:7726-7733.
45. Seuwen K, Lagarde A, and Pouyssegur J (1988) Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C. EMBO (Eur Mol Biol Organ) J 7:161-168.
46. Sheridan CM, Heist EK, Beals CR, Crabtree GR, and Gardner P (2002) Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3. J Biol Chem 277:48664-48676.
47. Shichijo M, Inagaki N, Kimata M, Serizawa I, Saito H, and Nagai H (1999) Role of cyclic 3′,5′-adenosine monophosphate in the regulation of chemical mediator release and cytokine production from cultured human mast cells. J Allergy Clin Immunol 103:S421-S428.
48. Steinke JW and Borish L (2001) Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Resp Res 2:66-70.
49. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, et al. (2003) Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med 9:1506-1512.
50. Timmerman LA, Healy JI, Ho SN, Chen L, Goodnow CC, and Crabtree GR (1997) Redundant expression but selective utilization of nuclear factor of activated T cells family members. J Immunol 159:2735-2740.
51. Tokoyoda K, Tsujikawa K, Matsushita H, Ono Y, Hayashi T, Harada Y, Abe R, Kubo M, and Yamamoto H (2004) Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells. Int Immunol 16:643-653.
52. Tsuruta L, Lee HJ, Masuda ES, Koyano-Nakagawa N, Arai N, Arai K, and Yokota T (1995) Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP. J Immunol 154:5255-5264.
53. 2B receptors. Biochem Pharmacol 70:1601-1612.
54. Wang M, Saxon A, and Diaz-Sanchez D (1999) Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived. Clin Immunol 90:47-54.
55. Weiss DL and Brown MA (2001) Regulation of IL-4 production in mast cells: a paradigm for cell-type-specific gene expression. Immunol Rev 179:35-47.
56. Weiss DL, Hural J, Tara D, Timmerman LA, Henkel G, and Brown MA (1996) Nuclear factor of activated T cells is associated with a mast cell interleukin 4 transcription complex. Mol Cel Biol 16:228-235.
57. Wilson BA and Ho M (2004) Pasteurella multocida toxin as a tool for studying Gq signal transduction. Rev Physiol Biochem Pharmacol 152:93-109.
58. Wirth S, Lacour M, Jaunin F, and Hauser C (1996) Cyclic adenosine monophosphate (cAMP) differentially regulates IL-4 in thymocyte subsets. Thymus 24:101-109.
59. Yamaguchi M, Sayama K, Yano K, Lantz CS, Noben-Trauth N, Ra C, Costa JJ, and Galli SJ (1999) IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release. J Immunol 162:5455-5465.
60. 2B adenosine receptor antagonist for the potential treatment of asthma. Bioorg Med Chem Lett 15:609-612.
61. Zhong H, Chunn JL, Volmer JB, Fozard JR, and Blackburn MR (2001) Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice. J Pharmacol Exp Ther 298:433-440.