IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia

Frontiers in Cellular Neuroscience

Volumn 8, Issue JULY, 2014, Pages

  Ferreira, Roger ^a,b   Lively, Starlee ^a   Schlichter, Lyanne C ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alternative microglial activation; AP 1 transcription factor; IL 4 signaling; KCa3.1 SK4 channel; M2 macrophage activation; Microglial migration; Ras MEK ERK signaling; Type I IL 4 receptor

Indexed keywords

ARGINASE 1; CALCIUM ACTIVATED POTASSIUM CHANNEL; CD163 ANTIGEN; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR TYPE I; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; KCA3.1 CHANNEL; KCNN4 PROTEIN; MANNOSE RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C FOS; PROTEIN C JUN; PURINERGIC P2Y2 RECEPTOR; RAF PROTEIN; RAS PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE EXPRESSION; MEMBRANE CURRENT; MICROGLIA; NONHUMAN; PATCH CLAMP TECHNIQUE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84903714533     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00183     Document Type: Article

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