메뉴 건너뛰기




Volumn 3, Issue 3, 2010, Pages 385-396

Therapeutic potential of KCa3.1 blockers: Recent advances and promising trends

Author keywords

Asthma; Atherosclerosis; Fibrosis; ICA 17043; KCa3.1; Restenosis; Sickle cell disease; TRAM 34

Indexed keywords

11 PHENYLDIBENZAZEPINE; 4 PHENYL 4H PYRAN; 5,6 DICHLOROETHYLBENZIMIDAZOLONE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL L TYPE; CLOTRIMAZOLE; CYCLOHEXADIENE; CYCLOHEXADIENE LACTONE; DIPHENYLINDANONE; ETHYLBENZIMIDAZOLONE; FLINDOKALNER; NIFEDIPINE; NS 309; PLACEBO; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCA3.1; RILUZOLE; SENICAPOC; SKA 31; SULFONAMIDE; TRAM 34; UNCLASSIFIED DRUG;

EID: 77952557868     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/ecp.10.11     Document Type: Review
Times cited : (170)

References (105)
  • 1
    • 29844439979 scopus 로고    scopus 로고
    • International Union of Pharmacology. LI I. Nomenclature and molecular relationships of calcium-activated potassium channels
    • Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. International Union of Pharmacology. LI I. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol. Rev. 57 (4), 463-472 (2005).
    • (2005) Pharmacol. Rev. , vol.57 , Issue.4 , pp. 463-472
    • Wei, A.D.1    Gutman, G.A.2    Aldrich, R.3    Chandy, K.G.4    Grissmer, S.5    Wulff, H.6
  • 2
    • 0030987549 scopus 로고    scopus 로고
    • HSK4, a member of a novel subfamily of calcium-activated potassium channels
    • Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl Acad. Sci. USA 94 (20), 11013-11018 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , Issue.20 , pp. 11013-11018
    • Joiner, W.J.1    Wang, L.Y.2    Tang, M.D.3    Kaczmarek, L.K.4
  • 4
    • 0031455164 scopus 로고    scopus 로고
    • A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes
    • Logsdon NJ, Kang J, Togo JA, Christian EP, Aiyar J. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. J. Biol. Chem. 272, 32723-32726 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 32723-32726
    • Logsdon, N.J.1    Kang, J.2    Togo, J.A.3    Christian, E.P.4    Aiyar, J.5
  • 5
    • 0032189766 scopus 로고    scopus 로고
    • Mechanism of calcium gating in smallconductance calcium-activated potassium channels
    • Ca 2 channels have calmodulin bound to their C-terminus
    • Ca 2 channels have calmodulin bound to their C-terminus.
    • (1998) Nature , vol.395 , Issue.6701 , pp. 503-507
    • Xia, X.M.1    Fakler, B.2    Rivard, A.3
  • 7
    • 25844523898 scopus 로고    scopus 로고
    • Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation
    • Cheong A, Bingham AJ, Li J et al Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation. Mol. Cell 20 (1), 45-52 (2005).
    • (2005) Mol. Cell. , vol.20 , Issue.1 , pp. 45-52
    • Cheong, A.1    Bingham, A.J.2    Li, J.3
  • 8
    • 0034711234 scopus 로고    scopus 로고
    • KCal potassium channel during T-cell activation: Molecular mechanism and functional consequences
    • KCal potassium channel during T-cell activation: molecular mechanism and functional consequences. J. Biol. Chem. 275, 37137-37149 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 37137-37149
    • Ghanshani, S.1    Wulff, H.2    Miller, M.J.3
  • 9
    • 0034614418 scopus 로고    scopus 로고
    • Kinase-dependent regulation of the intermediate conductance, calciumdependent potassium channel, hIK1
    • Gerlach AC, Gangopadhyay NN, Devor DC. Kinase-dependent regulation of the intermediate conductance, calciumdependent potassium channel, hIK1. J. Biol. Chem. 275, 585-598 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 585-598
    • Gerlach, A.C.1    Gangopadhyay, N.N.2    Devor, D.C.3
  • 10
    • 33751513093 scopus 로고    scopus 로고
    • Ca 3. 1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells
    • Ca 3.1 activity is regulated by a histidine kinase, which is a very rare form of regulation in mammals
    • Ca 3.1 activity is regulated by a histidine kinase, which is a very rare form of regulation in mammals.
    • (2006) Mol. Cell. , vol.24 , Issue.5 , pp. 665-675
    • Srivastava, S.1    Li, Z.2    Ko, K.3
  • 13
    • 0032739621 scopus 로고    scopus 로고
    • Ca channel, FIK, as a prototype for the cell growth regulatory function of the IK channel family
    • Ca channel, FIK, as a prototype for the cell growth regulatory function of the IK channel family. J. Membr. Biol. 172, 249-257 (1999).
    • (1999) J. Membr. Biol. , vol.172 , pp. 249-257
    • Pena, T.L.1    Rane, S.G.2
  • 14
    • 0033615419 scopus 로고    scopus 로고
    • + channel in vascular smooth muscle: Relationship between KCa channel diversity and smooth muscle cell function
    • + channel in vascular smooth muscle: relationship between KCa channel diversity and smooth muscle cell function. Circ. Res. 85, e33-e43 (1999).
    • (1999) Circ. Res. , vol.85
    • Neylon, C.B.1    Lang, R.J.2    Fu, Y.3    Bobik, A.4    Reinhart, P.H.5
  • 15
    • 16244369402 scopus 로고    scopus 로고
    • Blockade of the intermediate-conductance calciumactivated potassium channel as a new therapeutic strategy for restenosis
    • Ca 3.1 constitutes a target for the prevention of restenosis
    • Ca 3.1 constitutes a target for the prevention of restenosis.
    • (2003) Circulation , vol.108 , Issue.9 , pp. 1119-1125
    • Kohler, R.1    Wulff, H.2    Eichler, I.3
  • 16
    • 3042594481 scopus 로고    scopus 로고
    • + channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum
    • + channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Naunyn-Schmiedebergs Arch. Pharmacol. 369 (6), 602-615 (2004).
    • (2004) Naunyn-Schmiedebergs Arch. Pharmacol. , vol.369 , Issue.6 , pp. 602-615
    • Chen, M.X.1    Gorman, S.A.2    Benson, B.3
  • 17
    • 16244383259 scopus 로고    scopus 로고
    • + channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo
    • + channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo. Arterioscler. Thromb. Vasc. Biol. 25 (4), 704-709 (2005).
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , Issue.4 , pp. 704-709
    • Grgic, I.1    Eichler, I.2    Heinau, P.3
  • 18
    • 0000659323 scopus 로고
    • The function of calcium in the potassium permeability of human erythrocytes
    • Gardos G. The function of calcium in the potassium permeability of human erythrocytes. Biochem. Biophys. Acta 30, 653-654 (1958).
    • (1958) Biochem. Biophys. Acta , vol.30 , pp. 653-654
    • Gardos, G.1
  • 19
    • 0032555481 scopus 로고    scopus 로고
    • + channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation
    • + channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J. Biol. Chem. 273 (34), 21542-21553 (1998).
    • (1998) J. Biol. Chem. , vol.273 , Issue.34 , pp. 21542-21553
    • Vandorpe, D.H.1    Shmukler, B.E.2    Jiang, L.3
  • 22
    • 0037298183 scopus 로고    scopus 로고
    • IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis
    • Elliott JI, Higgins CF. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis. EMBO Rep. 4 (2), 189-194 (2003).
    • (2003) EMBO Rep. , vol.4 , Issue.2 , pp. 189-194
    • Elliott, J.I.1    Higgins, C.F.2
  • 23
    • 40449087467 scopus 로고    scopus 로고
    • Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death
    • Taylor SR, Gonzalez-Begne M, Dewhurst S et al. Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. J. Immunol. 180 (1), 300-308 (2008).
    • (2008) J. Immunol. , vol.180 , Issue.1 , pp. 300-308
    • Taylor, S.R.1    Gonzalez-Begne, M.2    Dewhurst, S.3
  • 24
    • 66949116366 scopus 로고    scopus 로고
    • Ca3.1) in the inner mitochondrial membrane of human colon cancer cells
    • Ca3.1) in the inner mitochondrial membrane of human colon cancer cells. Cell Calcium 45 (5), 509-516 (2009).
    • (2009) Cell. Calcium , vol.45 , Issue.5 , pp. 509-516
    • De Marchi, U.1    Sassi, N.2    Fioretti, B.3
  • 26
    • 0040735682 scopus 로고    scopus 로고
    • Ras/MEK/ERK up-regulation of the fibroblast KCa channel FIK is a common mechanism for basic fibroblast growth factor and transforming growth factor-β suppression of myogenesis
    • Pena TL, Chen SH, Konieczny SF, Rane SG. Ras/MEK/ERK up-regulation of the fibroblast KCa channel FIK is a common mechanism for basic fibroblast growth factor and transforming growth factor-β suppression of myogenesis. J. Biol. Chem. 275 (18), 13677-13682 (2000).
    • (2000) J. Biol. Chem. , vol.275 , Issue.18 , pp. 13677-13682
    • Pena, T.L.1    Chen, S.H.2    Konieczny, S.F.3    Rane, S.G.4
  • 27
    • 3142775617 scopus 로고    scopus 로고
    • + channel expression during B-cell differentiation: Implications for immunomodulation and autoimmunity
    • + channel expression during B-cell differentiation: implications for immunomodulation and autoimmunity. J. Immunol. 173, 776-786 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 776-786
    • Wulff, H.1    Knaus, H.G.2    Pennington, M.3    Chandy, K.G.4
  • 28
    • 0036149403 scopus 로고    scopus 로고
    • Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: Implication for HIV-1-associated dementia
    • Chung I, Zelivyanskaya M, Gendelman HE. Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: implication for HIV-1- associated dementia. J. Neuroimmunol. 122 (1-2), 40-54 (2002).
    • (2002) J. Neuroimmunol. , vol.122 , Issue.1-2 , pp. 40-54
    • Chung, I.1    Zelivyanskaya, M.2    Gendelman, H.E.3
  • 30
    • 34250215816 scopus 로고    scopus 로고
    • Functional upregulation of intermediate conductance calcium activated potassium channels is necessary for coronary smooth muscle cell dedifferentiation and migration
    • Tharp DL, Casati J, Turk JR, Bowles DK. Functional upregulation of intermediate conductance calcium activated potassium channels is necessary for coronary smooth muscle cell dedifferentiation and migration. FASEB J. 19, A1628 (2005).
    • (2005) FASEB J. , vol.19
    • Tharp, D.L.1    Casati, J.2    Turk, J.R.3    Bowles, D.K.4
  • 33
    • 33846122620 scopus 로고    scopus 로고
    • Ca3.1 contributes to microglia activation and nitric oxidedependent neurodegeneration
    • Ca3.1 contributes to microglia activation and nitric oxidedependent neurodegeneration. J. Neurosci. 27 (1), 234-244 (2007).
    • (2007) J. Neurosci. , vol.27 , Issue.1 , pp. 234-244
    • Kaushal, V.1    Koeberle, P.D.2    Wang, Y.3    Schlichter, L.C.4
  • 34
    • 33749365019 scopus 로고    scopus 로고
    • Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel
    • Wolfs JL, Wielders SJ, Comfurius P et al. Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel. Blood 108 (7), 2223-2228 (2006).
    • (2006) Blood , vol.108 , Issue.7 , pp. 2223-2228
    • Wolfs, J.L.1    Wielders, S.J.2    Comfurius, P.3
  • 35
    • 0029658673 scopus 로고    scopus 로고
    • The antifungal antibiotic, clotriamzole, inhibits Clsecretion by polarized monolayers of human colonic epithelial cells
    • Rufo PA, Jiang L, Moe SJ, Brugnara C, Alper SL, Lencer WI. The antifungal antibiotic, clotriamzole, inhibits Clsecretion by polarized monolayers of human colonic epithelial cells. J. Clin. Invest. 98, 2066-2075 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 2066-2075
    • Rufo, P.A.1    Jiang, L.2    Moe, S.J.3    Brugnara, C.4    Alper, S.L.5    Lencer, W.I.6
  • 38
  • 39
    • 0037295387 scopus 로고    scopus 로고
    • +-channels suppresses EDHF-mediated vasodilation
    • +-channels suppresses EDHF-mediated vasodilation. Br. J. Pharmacol. 138 (4), 594-601 (2003).
    • (2003) Br. J. Pharmacol. , vol.138 , Issue.4 , pp. 594-601
    • Eichler, I.1    Wibawa, J.2    Grgic, I.3
  • 41
    • 70349895458 scopus 로고    scopus 로고
    • + channels in normal and impaired EDHF-dilator responses - Relevance to cardiovascular pathologies and drug discovery
    • + channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery. Br. J. Pharmacol. 157 (4), 509-526 (2009).
    • (2009) Br. J. Pharmacol. , vol.157 , Issue.4 , pp. 509-526
    • Grgic, I.1    Kaistha, B.P.2    Hoyer, J.3    Kohler, R.4
  • 42
    • 66349089328 scopus 로고    scopus 로고
    • K1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension
    • Ca 3.1 play a critical role in mediating the endothelium-derived hyperpolarizing factor response
    • Ca 3.1 play a critical role in mediating the endothelium-derived hyperpolarizing factor response.
    • (2009) Circulation , vol.119 , Issue.17 , pp. 2323-2332
    • Brahler, S.1    Kaistha, A.2    Schmidt, V.J.3
  • 44
    • 45149098981 scopus 로고    scopus 로고
    • Ca 3.1 channels during endotheliumderived hyperpolarizing factor signaling in mesenteric resistance arteries
    • Ca 3.1 channels during endotheliumderived hyperpolarizing factor signaling in mesenteric resistance arteries. Circ. Res. 102 (10), 1247-1255 (2008).
    • (2008) Circ. Res. , vol.102 , Issue.10 , pp. 1247-1255
    • Dora, K.A.1    Gallagher, N.T.2    McNeish, A.3    Garland, C.J.4
  • 45
    • 47749105331 scopus 로고    scopus 로고
    • Functional architecture of inositol 1, 4, 5-trisphosphate signaling in restricted spaces of myoendothelial projections
    • Ledoux J, Taylor MS, Bonev AD et al Functional architecture of inositol 1, 4, 5-trisphosphate signaling in restricted spaces of myoendothelial projections. Proc. Natl Acad. Sci. USA 105 (28), 9627-9632 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.28 , pp. 9627-9632
    • Ledoux, J.1    Taylor, M.S.2    Bonev, A.D.3
  • 46
    • 67349255451 scopus 로고    scopus 로고
    • Ca 3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly
    • Ca 3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly. Pflugers Arch. 458 (2), 291-302 (2009).
    • (2009) Pflugers Arch. , vol.458 , Issue.2 , pp. 291-302
    • Grgic, I.1    Kaistha, B.P.2    Paschen, S.3
  • 48
    • 34250213865 scopus 로고    scopus 로고
    • Modulators of small- and intermediate-conductance calciumactivated potassium channels and their therapeutic indications
    • Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V. Modulators of small- and intermediate-conductance calciumactivated potassium channels and their therapeutic indications. Curr. Med. Chem. 14 (13), 1437-1457 (2007).
    • (2007) Curr. Med. Chem. , vol.14 , Issue.13 , pp. 1437-1457
    • Wulff, H.1    Kolski-Andreaco, A.2    Sankaranarayanan, A.3    Sabatier, J.M.4    Shakkottai, V.5
  • 55
    • 0029865706 scopus 로고    scopus 로고
    • Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease
    • Ca 3.1 blockade with clotrimazole reduces erythrocyte dehydration in patients with sickle cell anemia
    • Ca 3.1 blockade with clotrimazole reduces erythrocyte dehydration in patients with sickle cell anemia.
    • (1996) J. Clin. Invest. , vol.97 , Issue.5 , pp. 1227-1234
    • Brugnara, C.1    Gee, B.2    Armsby, C.C.3
  • 56
    • 0033694996 scopus 로고    scopus 로고
    • Effects of imidazole antimycotics on the liver microsomal cytochrome P450 isoforms in rats: Comparison of in vitro and ex vivo studies
    • Suzuki S, Kurata N, Nishimura Y, Yasuhara H, Satoh T Effects of imidazole antimycotics on the liver microsomal cytochrome P450 isoforms in rats: comparison of in vitro and ex vivo studies. Eur. J. Drug Metab. Pharmacokinet. 25 (2), 121-126 (2000).
    • (2000) Eur. J. Drug Metab. Pharmacokinet. , vol.25 , Issue.2 , pp. 121-126
    • Suzuki, S.1    Kurata, N.2    Nishimura, Y.3    Yasuhara, H.4    Satoh, T.5
  • 57
    • 0035987895 scopus 로고    scopus 로고
    • CYP3A4 induction by drugs: Correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes
    • Luo G, Cunningham M, Kim S et al CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab. Dispos. 30 (7), 795-804 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.7 , pp. 795-804
    • Luo, G.1    Cunningham, M.2    Kim, S.3
  • 60
    • 39749096542 scopus 로고    scopus 로고
    • Novel inhibitors of the Gardos channel for the treatment of sickle cell disease
    • McNaughton-Smith GA, Burns JF, Stocker J W et al. Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J. Med. Chem. 51 (4), 976-982 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.4 , pp. 976-982
    • McNaughton-Smith, G.A.1    Burns, J.F.2    Stocker, J.W.3
  • 61
    • 33750695012 scopus 로고    scopus 로고
    • Dose-escalation study of ICA-17043 in patients with sickle cell disease
    • Ataga KI, Orringer EP, Styles L et al Dose-escalation study of ICA-17043 in patients with sickle cell disease. Pharmacotherapy 26 (11), 1557-1564 (2006).
    • (2006) Pharmacotherapy , vol.26 , Issue.11 , pp. 1557-1564
    • Ataga, K.I.1    Orringer, E.P.2    Styles, L.3
  • 62
    • 77952565390 scopus 로고    scopus 로고
    • Formulation-based approach to support early drug discovery and development efforts: A case study for entereric microencapsulation of a novel immunosuppressant TRAM-34
    • press
    • Abbassi M, Shresta S, Raman G et al. Formulation-based approach to support early drug discovery and development efforts: a case study for entereric microencapsulation of a novel immunosuppressant TRAM-34. J. Microencapsulation (2009) (In press).
    • (2009) J. Microencapsulation
    • Abbassi, M.1    Shresta, S.2    Raman, G.3
  • 65
    • 8144221598 scopus 로고    scopus 로고
    • Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma
    • Ca 3.1 blocker has beneficial effects in traumatic brain injury
    • Ca 3.1 blocker has beneficial effects in traumatic brain injury.
    • (2004) Eur. J. Neurosci. , vol.20 , Issue.7 , pp. 1761-1768
    • Mauler, F.1    Hinz, V.2    Horvath, E.3
  • 69
    • 0035146762 scopus 로고    scopus 로고
    • Benzimidazolone activators of chloride secretion: Potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease
    • Singh S, Syme CA, Singh AK, Devor DC, Bridges RJ. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J. Pharmacol. Exp. Ther. 296 (2), 600-611 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , Issue.2 , pp. 600-611
    • Singh, S.1    Syme, C.A.2    Singh, A.K.3    Devor, D.C.4    Bridges, R.J.5
  • 71
    • 59449098672 scopus 로고    scopus 로고
    • Ca 3.1 potassium channels, potentiates the endothelium-derived hyper polarizing factor response and lowers blood pressure
    • Ca 3.1 potassium channels, potentiates the endothelium-derived hyper polarizing factor response and lowers blood pressure. Mol. Pharmacol. 75 (2), 281-295 (2009).
    • (2009) Mol. Pharmacol. , vol.75 , Issue.2 , pp. 281-295
    • Sankaranarayanan, A.1    Raman, G.2    Busch, C.3
  • 73
    • 41549129593 scopus 로고    scopus 로고
    • KCa3.1: Target and marker for cancer, autoimmune disorder and vascular inflammation?
    • Chou CC, Lunn CA, Murgolo NJ. KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation? Expert Rev. Mol. Diagn. 8 (2), 179-187 (2008).
    • (2008) Expert Rev. Mol. Diagn. , vol.8 , Issue.2 , pp. 179-187
    • Chou, C.C.1    Lunn, C.A.2    Murgolo, N.J.3
  • 74
    • 0027275040 scopus 로고
    • + transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives
    • + transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J. Clin. Invest. 92, 520-526 (1993).
    • (1993) J. Clin. Invest. , vol.92 , pp. 520-526
    • Brugnara, C.1    De Franceschi, L.2    Alper, S.L.3
  • 76
    • 0038481183 scopus 로고    scopus 로고
    • + channel in effector memory T cells as new target for MS
    • + channel in effector memory T cells as new target for MS. J. Clin. Invest. 111, 1703-1713 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 1703-1713
    • Wulff, H.1    Calabresi, P.A.2    Allie, R.3
  • 78
    • 20244366860 scopus 로고    scopus 로고
    • Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice
    • Reich EP, Cui L, Yang L et al. Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice. Eur. J. Immunol 35 (4), 1027-1036 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , Issue.4 , pp. 1027-1036
    • Reich, E.P.1    Cui, L.2    Yang, L.3
  • 79
    • 77952562884 scopus 로고    scopus 로고
    • Blocking ion channel KCNN4 alleviates inflammation symptoms by arresting the synthesis of key proinflammatory factors
    • CA, USA
    • Chou CC. Blocking ion channel KCNN4 alleviates inflammation symptoms by arresting the synthesis of key proinflammatory factors. In: IBC Assays and Cellular Targets. CA, USA (2005).
    • (2005) IBC Assays and Cellular Targets.
    • Chou, C.C.1
  • 82
    • 76549083562 scopus 로고    scopus 로고
    • Ca 3.1 ameliorates T cell mediated colitis
    • Ca 3.1 might constitute a therapeutic target for inflammatory bowel disease
    • Ca 3.1 might constitute a therapeutic target for inflammatory bowel disease.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , Issue.4 , pp. 1541-1546
    • Di, L.1    Srivastava, S.2    Zhdanova, O.3
  • 84
    • 70350344966 scopus 로고    scopus 로고
    • V1.3 as novel targets for asthma therapy
    • V1.3 as novel targets for asthma therapy. Br. J. Pharmacol. 157 (8), 1330-1339 (2009).
    • (2009) Br. J. Pharmacol. , vol.157 , Issue.8 , pp. 1330-1339
    • Bradding, P.1    Wulff, H.2
  • 87
    • 51349157566 scopus 로고    scopus 로고
    • Ca3.1 contributes to atherogenesis in mice and humans
    • Ca 3.1 might constitute a target for atherosclerosis
    • Ca 3.1 might constitute a target for atherosclerosis.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3025-3037
    • Toyama, K.1    Wulff, H.2    Chandy, K.G.3
  • 90
    • 34547631040 scopus 로고    scopus 로고
    • + channels inhibits progression of human endometrial cancer
    • + channels inhibits progression of human endometrial cancer. Oncogene 26 (35), 5107-5114 (2007).
    • (2007) Oncogene , vol.26 , Issue.35 , pp. 5107-5114
    • Wang, Z.H.1    Shen, B.2    Yao, H.L.3
  • 91
    • 50849139524 scopus 로고    scopus 로고
    • Ca 3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease
    • Ca 3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease. Kidney Int. 74 (6), 740-749 (2008).
    • (2008) Kidney Int. , vol.74 , Issue.6 , pp. 740-749
    • Albaqumi, M.1    Srivastava, S.2    Li, Z.3
  • 93
    • 0031453854 scopus 로고    scopus 로고
    • + conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera
    • + conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. J. Clin. Invest. 100 (12), 3111-3120 (1997).
    • (1997) J. Clin. Invest. , vol.100 , Issue.12 , pp. 3111-3120
    • Rufo, P.A.1    Merlin, D.2    Riegler, M.3
  • 94
    • 65549109899 scopus 로고    scopus 로고
    • ® (ICA-17043): A potential therapy for the prevention and treatment of hemolysisassociated complications in sickle cell anemia
    • •• Review summarizing the safety, pharmacokinetics and Phase II trial results for Senicapoc
    • ® (ICA-17043): a potential therapy for the prevention and treatment of hemolysisassociated complications in sickle cell anemia. Expert Opin. Invest. Drugs 18 (2), 231-239 (2009). •• Review summarizing the safety, pharmacokinetics and Phase II trial results for Senicapoc.
    • (2009) Expert Opin. Invest. Drugs , vol.18 , Issue.2 , pp. 231-239
    • Ataga, K.I.1    Stocker, J.2
  • 95
    • 43249105788 scopus 로고    scopus 로고
    • ® (ICA-17043), in patients with sickle cell anemia
    • ® (ICA-17043), in patients with sickle cell anemia. Blood 111 (8), 3991-3997 (2008).
    • (2008) Blood , vol.111 , Issue.8 , pp. 3991-3997
    • Ataga, K.I.1    Smith, W.R.2    De Castro, L.M.3
  • 96
    • 77952558653 scopus 로고    scopus 로고
    • A 48-week open-label study of Sincapoc (ICA-17042), a Gardos channel blocker, in patients with sickle cell disease
    • Abstract 685
    • Swerdlow P, Ataga KI, Smith W, Saunthararajah Y, Stocker JW A 48-week open-label study of Sincapoc (ICA-17042), a Gardos channel blocker, in patients with sickle cell disease. Blood 108, (2006) (Abstract 685).
    • (2006) Blood , vol.108
    • Swerdlow, P.1    Ataga, K.I.2    Smith, W.3    Saunthararajah, Y.4    Stocker, J.W.5
  • 97
    • 0035052573 scopus 로고    scopus 로고
    • Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
    • Gribkoff VK, Starrett JE, Dworetzky SI et al. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nat. Med. 7, 471-477 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 471-477
    • Gribkoff, V.K.1    Starrett, J.E.2    Dworetzky, S.I.3
  • 98
    • 0036961830 scopus 로고    scopus 로고
    • BMS-204352: A potassium channel opener developed for the treatment of stroke
    • Jensen BS. BMS-204352: a potassium channel opener developed for the treatment of stroke. CNS Drug Rev. 8 (4), 353-360 (2002).
    • (2002) CNS Drug Rev. , vol.8 , Issue.4 , pp. 353-360
    • Jensen, B.S.1
  • 100
    • 77952576618 scopus 로고    scopus 로고
    • President and Fellows of Harvard College; Children Medical Center Corporation; Ion Pharmaceuticals. Inc., WO9734589
    • President and Fellows of Harvard College; Children Medical Center Corporation; Ion Pharmaceuticals. Inc., WO9734589 (1997).
    • (1997)
  • 101
    • 77952570428 scopus 로고    scopus 로고
    • President and Fellows of Harvard College; Children Medical Center Corporation; NuChem Pharmaceuticals Inc., US6992079
    • President and Fellows of Harvard College; Children Medical Center Corporation; NuChem Pharmaceuticals Inc., US6992079 (2006).
    • (2006)
  • 102
    • 77952566341 scopus 로고    scopus 로고
    • President and Fellows of Harvard College; Children Medical Center Corporation; NuChem Pharmaceuticals Inc., US7342038
    • President and Fellows of Harvard College; Children Medical Center Corporation; NuChem Pharmaceuticals Inc., US7342038 (2008).
    • (2008)
  • 103
    • 77952563162 scopus 로고    scopus 로고
    • Icagen Inc., US7119112
    • Icagen Inc., US7119112 (2006).
    • (2006)
  • 104
    • 77952557093 scopus 로고    scopus 로고
    • Germany, DE-9619612645
    • Bayer A G, Germany, DE-9619612645 (1997).
    • (1997)
    • Bayer, A.G.1
  • 105
    • 77952575474 scopus 로고    scopus 로고
    • Icagen company press release. 26 October
    • Icagen company press release. 26 October 2009 www.icagen. com
    • (2009)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.