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Volumn , Issue , 2012, Pages

Microglial KCa3.1 channels as a potential therapeutic target for Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; CLOTRIMAZOLE; CYCLOHEXADIENE LACTONE; NONSTEROID ANTIINFLAMMATORY AGENT; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCA3.1; SENICAPOC; UNCLASSIFIED DRUG;

EID: 84862277780     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.1155/2012/868972     Document Type: Review
Times cited : (57)

References (63)
  • 1
    • 84862297965 scopus 로고    scopus 로고
    • Accelerating drug discovery for Alzheimer's disease: Best practices for preclinical animal studies
    • ARTICLE 28
    • Shineman D. W., Basi G. S., Bizon J. L., Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies Alzheimer's Research Therapy 2011 3 5, article 28
    • (2011) Alzheimer's Research Therapy , vol.3 , Issue.5
    • Shineman, D.W.1    Basi, G.S.2    Bizon, J.L.3
  • 2
    • 78751692575 scopus 로고    scopus 로고
    • Anti-A therapeutics in alzheimer's disease: The need for a paradigm shift
    • Golde T. E., Schneider L. S., Koo E. H., Anti-A therapeutics in alzheimer's disease: the need for a paradigm shift Neuron 2011 69 2 203 213
    • (2011) Neuron , vol.69 , Issue.2 , pp. 203-213
    • Golde, T.E.1    Schneider, L.S.2    Koo, E.H.3
  • 5
    • 40449127705 scopus 로고    scopus 로고
    • Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia
    • DOI 10.1159/000113679
    • Jellinger K. A., Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia Neurodegenerative Diseases 2008 5 3-4 118 121 (Pubitemid 351347827)
    • (2008) Neurodegenerative Diseases , vol.5 , Issue.3-4 , pp. 118-121
    • Jellinger, K.A.1
  • 6
    • 84155162975 scopus 로고    scopus 로고
    • Vascular risk factors and Alzheimer's disease: Are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review
    • ARTICLE 36
    • Chui H. C., Zheng L., Reed B. R., Vinters H. V., Mack W. J., Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review Alzheimer's Research Therapy 2012 3 6, article 36
    • (2012) Alzheimer's Research Therapy , vol.3 , Issue.6
    • Chui, H.C.1    Zheng, L.2    Reed, B.R.3    Vinters, H.V.4    MacK, W.J.5
  • 7
    • 35748959415 scopus 로고    scopus 로고
    • Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    • DOI 10.1212/01.wnl.0000271090.28148.24, PII 0000611420071211000005
    • Schneider J. A., Arvanitakis Z., Bang W., Bennett D. A., Mixed brain pathologies account for most dementia cases in community-dwelling older persons Neurology 2007 69 24 2197 2204 (Pubitemid 350294674)
    • (2007) Neurology , vol.69 , Issue.24 , pp. 2197-2204
    • Schneider, J.A.1    Arvanitakis, Z.2    Bang, W.3    Bennett, D.A.4
  • 10
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J., Selkoe D. J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 2002 297 5580 353 356 (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 11
    • 20444496481 scopus 로고    scopus 로고
    • Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
    • DOI 10.1074/jbc.M500997200
    • Demuro A., Mina E., Kayed R., Milton S. C., Parker I., Glabe C. G., Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers The Journal of Biological Chemistry 2005 280 17 17294 17300 (Pubitemid 41389198)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.17 , pp. 17294-17300
    • Demuro, A.1    Mina, E.2    Kayed, R.3    Milton, S.C.4    Parker, I.5    Glabe, C.G.6
  • 12
    • 84855750207 scopus 로고    scopus 로고
    • Single-channel Ca 2+ imaging implicates A 142 amyloid pores in Alzheimers disease pathology
    • Demuro A., Smith M., Parker I., Single-channel Ca 2+ imaging implicates A 142 amyloid pores in Alzheimers disease pathology Journal of Cell Biology 2011 195 515 524
    • (2011) Journal of Cell Biology , vol.195 , pp. 515-524
    • Demuro, A.1    Smith, M.2    Parker, I.3
  • 13
    • 8144221598 scopus 로고    scopus 로고
    • Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma
    • DOI 10.1111/j.1460-9568.2004.03615.x
    • Mauler F., Hinz V., Horvth E., Schuhmacher J., Hofmann H. A., Wirtz S., Hahn M. G., Urbahns K., Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma European Journal of Neuroscience 2004 20 7 1761 1768 (Pubitemid 39471569)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.7 , pp. 1761-1768
    • Mauler, F.1    Hinz, V.2    Horvath, E.3    Schuhmacher, J.4    Hofmann, H.A.5    Wirtz, S.6    Hahn, M.G.7    Urbahns, K.8
  • 14
    • 75149118999 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and mild cognitive impairment: A field in its infancy
    • McGeer E. G., McGeer P. L., Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy Journal of Alzheimer's Disease 2010 19 1 355 361
    • (2010) Journal of Alzheimer's Disease , vol.19 , Issue.1 , pp. 355-361
    • McGeer, E.G.1    McGeer, P.L.2
  • 17
    • 79952810857 scopus 로고    scopus 로고
    • Amyloid- protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity
    • Maezawa I., Zimin P. I., Wulff H., Jin L. W., Amyloid- protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity The Journal of Biological Chemistry 2011 286 5 3693 3706
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.5 , pp. 3693-3706
    • Maezawa, I.1    Zimin, P.I.2    Wulff, H.3    Jin, L.W.4
  • 18
    • 49449093147 scopus 로고    scopus 로고
    • The inflammatory response in Alzheimer's disease
    • Rogers J., The inflammatory response in Alzheimer's disease Journal of Periodontology 2008 79 8 1535 1543
    • (2008) Journal of Periodontology , vol.79 , Issue.8 , pp. 1535-1543
    • Rogers, J.1
  • 21
    • 56349166514 scopus 로고    scopus 로고
    • Mechanisms of microglia accumulation in Alzheimer's disease: Therapeutic implications
    • El Khoury J., Luster A. D., Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications Trends in Pharmacological Sciences 2008 29 12 626 632
    • (2008) Trends in Pharmacological Sciences , vol.29 , Issue.12 , pp. 626-632
    • El Khoury, J.1    Luster, A.D.2
  • 22
    • 75949127362 scopus 로고    scopus 로고
    • Inflammation, microglia, and alzheimer's disease
    • Cameron B., Landreth G. E., Inflammation, microglia, and alzheimer's disease Neurobiology of Disease 2010 37 3 503 509
    • (2010) Neurobiology of Disease , vol.37 , Issue.3 , pp. 503-509
    • Cameron, B.1    Landreth, G.E.2
  • 23
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective -amyloid clearance pathways in aging alzheimer's disease mice
    • Hickman S. E., Allison E. K., El Khoury J., Microglial dysfunction and defective -amyloid clearance pathways in aging alzheimer's disease mice Journal of Neuroscience 2008 28 33 8354 8360
    • (2008) Journal of Neuroscience , vol.28 , Issue.33 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 24
    • 42649098547 scopus 로고    scopus 로고
    • Microglial degeneration in the aging brain - Bad news for neurons?
    • DOI 10.2741/2937
    • Streit W. J., Miller K. R., Lopes K. O., Njie E., Microglial degeneration in the aging brainbad news for neurons? Frontiers in Bioscience 2008 13 9 3423 3438 (Pubitemid 351594693)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.9 , pp. 3423-3438
    • Streit, W.J.1    Miller, K.R.2    Lopes, K.O.3    Njie, E.4
  • 25
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: Too much or too little?
    • Lucin K. M., Wyss-Coray T., Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 2009 64 1 110 122
    • (2009) Neuron , vol.64 , Issue.1 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 28
    • 33846122620 scopus 로고    scopus 로고
    • + channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration
    • DOI 10.1523/JNEUROSCI.3593-06.2007
    • Kaushal V., Koeberle P. D., Wang Y., Schlichter L. C., The Ca 2+ -activated K + channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration Journal of Neuroscience 2007 27 1 234 244 (Pubitemid 46089977)
    • (2007) Journal of Neuroscience , vol.27 , Issue.1 , pp. 234-244
    • Kaushal, V.1    Koeberle, P.D.2    Wang, Y.3    Schlichter, L.C.4
  • 29
    • 82555189765 scopus 로고    scopus 로고
    • The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke
    • Chen Y. J., Raman G., Bodendiek S., O'Donnell M. E., Wulff H., The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke Journal of Cerebral Blood Flow and Metabolism 2011 31 12 2363 2374
    • (2011) Journal of Cerebral Blood Flow and Metabolism , vol.31 , Issue.12 , pp. 2363-2374
    • Chen, Y.J.1    Raman, G.2    Bodendiek, S.3    O'Donnell, M.E.4    Wulff, H.5
  • 30
    • 80755181221 scopus 로고    scopus 로고
    • Inhibition of the Ca 2+ -dependent K + channel, KCNN4/KCa3.1, improves tissue protection and locomotor recovery after spinal cord injury
    • Bouhy D., Ghasemlou N., Lively S., Redensek A., Rathore K.I., Schlichter L.C., David S., Inhibition of the Ca 2+ -dependent K + channel, KCNN4/KCa3.1, improves tissue protection and locomotor recovery after spinal cord injury The Journal of Neuroscience 2011 31 16298 16308
    • (2011) The Journal of Neuroscience , vol.31 , pp. 16298-16308
    • Bouhy, D.1    Ghasemlou, N.2    Lively, S.3    Redensek, A.4    Rathore, K.I.5    Schlichter, L.C.6    David, S.7
  • 32
    • 73449119314 scopus 로고    scopus 로고
    • Voltage-gated potassium channels as therapeutic targets
    • Wulff H., Castle N. A., Pardo L. A., Voltage-gated potassium channels as therapeutic targets Nature Reviews Drug Discovery 2009 8 12 982 1001
    • (2009) Nature Reviews Drug Discovery , vol.8 , Issue.12 , pp. 982-1001
    • Wulff, H.1    Castle, N.A.2    Pardo, L.A.3
  • 33
    • 70349162817 scopus 로고    scopus 로고
    • The functional network of ion channels in T lymphocytes
    • Cahalan M. D., Chandy K. G., The functional network of ion channels in T lymphocytes Immunological Reviews 2009 231 1 59 87
    • (2009) Immunological Reviews , vol.231 , Issue.1 , pp. 59-87
    • Cahalan, M.D.1    Chandy, K.G.2
  • 34
    • 0034711234 scopus 로고    scopus 로고
    • Up-regulation of the IKCa1 potassium channel during T-cell activation: Molecular mechanism and functional consequences
    • DOI 10.1074/jbc.M003941200
    • Ghanshani S., Wulff H., Miller M. J., Rohm H., Neben A., Gutman G. A., Cahalan M. D., Chandy K. G., Up-regulation of the IKCa1 potassium channel during T-cell activation: molecular mechanism and functional consequences The Journal of Biological Chemistry 2000 275 47 37137 37149 (Pubitemid 32002132)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 37137-37149
    • Ghanshani, S.1    Wulff, H.2    Miller, M.J.3    Rohm, H.4    Neben, A.5    Gutman, G.A.6    Cahalan, M.D.7    Chandy, K.G.8
  • 36
    • 3142775617 scopus 로고    scopus 로고
    • + channel expression during B cell differentiation: Implications for immunomodulation and autoimmunity
    • Wulff H., Knaus H. G., Pennington M., Chandy K. G., K + channel expression during B cell differentiation: implications for immunomodulation and autoimmunity Journal of Immunology 2004 173 2 776 786 (Pubitemid 38924252)
    • (2004) Journal of Immunology , vol.173 , Issue.2 , pp. 776-786
    • Wulff, H.1    Knaus, H.-G.2    Pennington, M.3    Chandy, K.G.4
  • 38
    • 1842556491 scopus 로고    scopus 로고
    • + channels for lysophosphatidic acid-induced microglial migration
    • DOI 10.1111/j.1460-9568.2004.03265.x
    • Schilling T., Stock C., Schwab A., Eder C., Functional importance of Ca 2+ -activated K + channels for lysophosphatidic acid-induced microglial migration European Journal of Neuroscience 2004 19 6 1469 1474 (Pubitemid 38437909)
    • (2004) European Journal of Neuroscience , vol.19 , Issue.6 , pp. 1469-1474
    • Schilling, T.1    Stock, C.2    Schwab, A.3    Eder, C.4
  • 40
    • 77952557868 scopus 로고    scopus 로고
    • Therapeutic potential of KCa3.1 blockers: Recent advances and promising trends
    • Wulff H., Castle N. A., Therapeutic potential of KCa3.1 blockers: recent advances and promising trends Expert Review of Clinical Pharmacology 2010 3 3 385 396
    • (2010) Expert Review of Clinical Pharmacology , vol.3 , Issue.3 , pp. 385-396
    • Wulff, H.1    Castle, N.A.2
  • 43
    • 0031455164 scopus 로고    scopus 로고
    • A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes
    • DOI 10.1074/jbc.272.52.32723
    • Logsdon N. J., Kang J., Togo J. A., Christian E. P., Aiyar J., A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes The Journal of Biological Chemistry 1997 272 52 32723 32726 (Pubitemid 28023600)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.52 , pp. 32723-32726
    • Logsdon, N.J.1    Kang, J.2    Togo, J.A.3    Christian, E.P.4    Aiyar, J.5
  • 45
    • 34250213865 scopus 로고    scopus 로고
    • Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications
    • DOI 10.2174/092986707780831186
    • Wulff H., Kolski-Andreaco A., Sankaranarayanan A., Sabatier J. M., Shakkottai V., Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications Current Medicinal Chemistry 2007 14 13 1437 1457 (Pubitemid 46902225)
    • (2007) Current Medicinal Chemistry , vol.14 , Issue.13 , pp. 1437-1457
    • Wulff, H.1    Kolski-Andreaco, A.2    Sankaranarayanan, A.3    Sabatier, J.-M.4    Shakkottai, V.5
  • 48
    • 44849100851 scopus 로고    scopus 로고
    • Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis
    • Tharp D. L., Wamhoff B. R., Wulff H., Raman G., Cheong A., Bowles D. K., Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 6 1084 1089
    • (2008) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.28 , Issue.6 , pp. 1084-1089
    • Tharp, D.L.1    Wamhoff, B.R.2    Wulff, H.3    Raman, G.4    Cheong, A.5    Bowles, D.K.6
  • 49
    • 55749114242 scopus 로고    scopus 로고
    • Reversed Na+/Ca 2+ exchange contributes to Ca 2+ influx and respiratory burst in microglia
    • Newell E. W., Stanley E. F., Schlichter L. C., Reversed Na+/Ca 2+ exchange contributes to Ca 2+ influx and respiratory burst in microglia. Channels (Austin, Tex.) 2007 1 5 366 376
    • (2007) Channels (Austin, Tex.) , vol.1 , Issue.5 , pp. 366-376
    • Newell, E.W.1    Stanley, E.F.2    Schlichter, L.C.3
  • 51
    • 0037551741 scopus 로고    scopus 로고
    • Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
    • DOI 10.1146/annurev.neuro.26.010302.081142
    • Caughey B., Lansbury P. T., Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders Annual Review of Neuroscience 2003 26 267 298 (Pubitemid 37064935)
    • (2003) Annual Review of Neuroscience , vol.26 , pp. 267-298
    • Caughey, B.1    Lansbury Jr., P.T.2
  • 52
    • 34249860495 scopus 로고    scopus 로고
    • Small molecule inhibitors of aggregation indicate that amyloid β oligomerization and fibrillization pathways are independent and distinct
    • DOI 10.1074/jbc.M608207200
    • Necula M., Kayed R., Milton S., Glabe C. G., Small molecule inhibitors of aggregation indicate that amyloid oligomerization and fibrillization pathways are independent and distinct The Journal of Biological Chemistry 2007 282 14 10311 10324 (Pubitemid 47093410)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.14 , pp. 10311-10324
    • Necula, M.1    Kayed, R.2    Milton, S.3    Glabe, C.G.4
  • 53
    • 57649148788 scopus 로고    scopus 로고
    • Structural classification of toxic amyloid oligomers
    • Glabe C. G., Structural classification of toxic amyloid oligomers The Journal of Biological Chemistry 2008 283 44 29639 29643
    • (2008) The Journal of Biological Chemistry , vol.283 , Issue.44 , pp. 29639-29643
    • Glabe, C.G.1
  • 58
    • 3042798841 scopus 로고    scopus 로고
    • β-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
    • DOI 10.1523/JNEUROSCI.0233-04.2004
    • Wang Q., Rowan M. J., Anwyl R., -amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide Journal of Neuroscience 2004 24 27 6049 6056 (Pubitemid 38891095)
    • (2004) Journal of Neuroscience , vol.24 , Issue.27 , pp. 6049-6056
    • Wang, Q.1    Rowan, M.J.2    Anwyl, R.3


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