Modafinil inhibits K Ca3.1 currents and muscle contraction via a cAMP-dependent mechanism

Pharmacological Research

Volumn 66, Issue 1, 2012, Pages 51-59

  Choi, Shinkyu ^a   Kim, Moon Young ^a,b   Joo, Ka Young ^a   Park, Seonghee ^a   Kim, Ji Aee ^a   Jung, Jae Chul ^a   Oh, Seikwan ^a   Suh, Suk Hyo ^a  

^a Ewha Womans University   (South Korea)

^b Eulji University   (South Korea)

Author keywords

Ca 2+ activated K + channel; cAMP; Modafinil; Phosphorylation; Vascular smooth muscle contraction

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; MODAFINIL; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; AORTA; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FIBROBLAST; IC 50; INHIBITION KINETICS; MOUSE; MUSCLE CONTRACTION; MYOGRAPHY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VOLTAGE CLAMP; WESTERN BLOTTING;

ANIMALS; BENZHYDRYL COMPOUNDS; CARRIER PROTEINS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME ACTIVATORS; FORSKOLIN; HUMANS; ILOPROST; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ISOQUINOLINES; MALE; MEMBRANE POTENTIALS; MICE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NIH 3T3 CELLS; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; POTASSIUM CHANNEL BLOCKERS; PROTEIN KINASE INHIBITORS; RATS; SECOND MESSENGER SYSTEMS; SULFONAMIDES; TIME FACTORS; UP-REGULATION; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 84862828635     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.02.009     Document Type: Article

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