SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 18, 2013, Pages

  Weisbrod, David ^a   Peretz, Asher ^a   Ziskind, Anna ^b   Menaker, Nataly ^a   Oz, Shimrit ^a   Barad, Lili ^b,c   Eliyahu, Sivan ^b   Itskovitz Eldor, Joseph ^b,d   Dascal, Nathan ^a   Khananshvili, Daniel ^a   Binah, Ofer ^b,c   Attali, Bernard ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b The Sohnis Family Stem Cells Center   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d Rappaport Family Institute for Research in the Medical Sciences ^*  (Israel)

Author keywords

Ca2+ activated K+ channel SK4; Calcium clock; Hyperpolarization activated cyclic nucleotide gated channel; Na+ Ca2+ exchanger; Voltage clock

Indexed keywords

CLOTRIMAZOLE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL; POTASSIUM CHANNEL SK4; UNCLASSIFIED DRUG; 1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; 2 (2 (4 (4 NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; DRUG DERIVATIVE; ICI D2788; KCNN4 PROTEIN, HUMAN; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RYANODINE RECEPTOR; THIOUREA;

ARTICLE; CELL POPULATION; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYONIC STEM CELL; HEART DEPOLARIZATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SINUS NODE; VOLTAGE CLAMP; WESTERN BLOTTING; ACTION POTENTIAL; BIOLOGICAL MODEL; CELL LINE; CYTOLOGY; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ACTION POTENTIALS; CELL LINE; EMBRYONIC STEM CELLS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; PYRAZOLES; PYRIMIDINES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SINOATRIAL NODE; THIOUREA;

MLCS; MLOWN;

EID: 84876906103     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221022110     Document Type: Article

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