RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase

Nature Communications

Volumn 5, Issue , 2014, Pages

  Tang, Songqing ^a,b   Chen, Taoyong ^b   Yu, Zhou ^a   Zhu, Xuhui ^b   Yang, Mingjin ^b,c   Xie, Bin ^a   Li, Nan ^b   Cao, Xuetao ^a,b,c   Wang, Jianli ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; I KAPPA B ALPHA; I KAPPA B BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE C; RAP1 PROTEIN; RAS GUANINE NUCLEOTIDE RELEASING PROTEIN 1; RAS GUANINE NUCLEOTIDE RELEASING PROTEIN 2; RAS GUANINE NUCLEOTIDE RELEASING PROTEIN 3; RAS GUANINE NUCLEOTIDE RELEASING PROTEIN 4; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; RASGRP3 PROTEIN, MOUSE; TLR3 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE;

CYTOLOGY; ENZYME ACTIVITY; GENOME; MOLECULAR ANALYSIS; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; CYTOKINE PRODUCTION; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; ENZYME ACTIVATION; FEMALE; INFLAMMATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DISEASE MODEL; EXPERIMENTAL ARTHRITIS; GENETICS; KNOCKOUT MOUSE; MACROPHAGE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GTP PHOSPHOHYDROLASES; INFLAMMATION; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RAP1 GTP-BINDING PROTEINS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS;

EID: 84907371287     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5657     Document Type: Article

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