Constitutive abnormal expression of RasGRP-1 isoforms and low expression of PARP-1 in patients with systemic lupus erythematosus

Lupus

Volumn 20, Issue 14, 2011, Pages 1501-1509

  Rapoport, M J ^a   Bloch, O ^a   Amit Vasina, M ^a   Yona, E ^a   Molad, Y ^b  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

Author keywords

apoptosis; MAP kinases; PARP 1; RasGRP 1; SLE

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN; RAS GUANIL RELEASING PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CORRELATION ANALYSIS; DISEASE ACTIVITY; FEMALE; FOLLOW UP; HUMAN; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMISSION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; DNA-BINDING PROTEINS; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROSPECTIVE STUDIES; PROTEIN ISOFORMS;

EID: 82955207664     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203311418790     Document Type: Article

References (45)

1. Rapoport MJ, Mor A, Amit M, et al. Decreased expression of the p21ras stimulatory factor hSOS in PBMC from inactive SLE patients. Lupus. 1999 ; 8: 24-28 (Pubitemid 29050216)
2. Deng C, Kaplan MJ, Yang J, et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum. 2001 ; 44: 397-407
3. Rapoport MJ, Amit M, Aharoni D, et al. Constitutive up-regulated activity of MAP kinase is associated with down-regulated early p21Ras pathway in lymphocytes of SLE patients. J Autoimmun. 2002 ; 9: 63-70 (Pubitemid 35205201)
4. Cedeno S, Cifarelli DF, Blasini AM, et al. Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells. Clin Immunol. 2003 ; 106: 41-49 (Pubitemid 36263301)
5. Yasuda S, Stevens RL, Terada T, et al. Defective expression of Ras Guanyl Nucleotide-Releasing Protein 1 in a subset of patients with systemic lupus erythematosus. J Immunol. 2007 ; 179: 4890-4900
6. Molad Y, Amit-Vasina M, Bloch O, Yona E, Rapoport MJ. Increased ERK and JNK activities correlate with disease activity in patients with systemic lupus erythematosus. Ann Rheum Dis. 2010 ; 69: 175-180
7. Katzav A, Kloog Y, Korczyn AD, et al. Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). Clin Exp Immunol. 2001 ; 126: 570-577 (Pubitemid 34008734)
8. Deng C, Lu Q, Zhang Z, et al. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum. 2003 ; 48: 746-756 (Pubitemid 36302012)
9. Rapoport MJ, Sharabi A, Aharoni D, et al. Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a downregulation of apoptosis and of the pro-apoptotic factor JNK kinase. Clin Immunol. 2005 ; 117: 262-270 (Pubitemid 43005212)
10. Wong CK, Wong PTY, Tam LS, Li EK, Chen DP, Lam CWK. Activation profile of intracellular Mitogen-Activated Protein Kinases in peripheral lymphocytes of patients with Systemic Lupus Erythematosus. J Clin Immunol. 2009 ; 29: 738-746
11. Mor A, Philips MR, Pillinger MH. The role of Ras signaling in lupus T lymphocytes: Biology and pathogenesis. Clin Immunol. 2007 ; 125: 215-223 (Pubitemid 350116716)
12. Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. JImmunol. 1994 ; 152: 3685-3692 (Pubitemid 24098067)
13. Lorenz H-M, Grünke M, Hieronymus T, et al. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum. 1997 ; 40: 306-317 (Pubitemid 27114095)
14. Perniok A, Wedekind F, Herrmann M, Specker C, Schneider M. High levels of circulating early apoptotic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus. 1998 ; 7: 113-118 (Pubitemid 28107976)
15. Gröndal G, Traustadottir KH, Kristjansdottir H, et al. Increased T-lymphocyte apoptosis/necrosis and IL-10 producing cells in patients and their spouses in Icelandic systemic lupus erythematosus multicase families. Lupus. 2002 ; 11: 435-442
16. Silvestris F, Grinello D, Tucci M, Cafforio P, Dammacco F. Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-I) in active lupus. Lupus. 2003 ; 12: 8-14 (Pubitemid 36172656)
17. Tao D, Shangwu L, Qun W, et al. CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus. J Immunol. 2005 ; 174: 1281-1290
18. Cerboni B, Morozzi G, Galeazzi M, et al. Poly(ADP-ribose) polymerase activity in systemic lupus erythematosus and systemic sclerosis. Hum Immunol. 2009 ; 70: 487-491
19. Lee Js , Haug BL, Sibley JT. Decreased mRNA levels coding for poly(ADP-ribose) polymerase in lymphocytes of patients with SLE. Lupus. 1994 ; 3: 113-116 (Pubitemid 24174636)
20. McCurdy D, Tai L-Q, Frias S, Wang Z. Delayed repair of DNA damage by ionizing radiation in cells from patients with systemic lupus erythematosus and juvenile rheumatoid arthritis. Radiat Res. 1997 ; 147: 48-54 (Pubitemid 27014446)
21. Simbulan-Rosenthal CM, Rosenthal DS, Iyer S, Boulares AH, Smulson ME. Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis. J Biol Chem. 1998 ; 273: 13703-13712 (Pubitemid 28268417)
22. Wilson DJ, Forther KA, Lynch DH, et al. JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells. Eur J Immunol. 1996 ; 26: 989-994 (Pubitemid 26158492)
23. Holmström TM, Schmitz I, Söderström TS, et al. MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. EMBO J. 2000 ; 19: 5418-5428
24. Gajate C, An F, Mollinedo F. Differential Cytostatic and Apoptotic effects of Ecteinascidin-743 in cancer cells. J Biol Chem. 2002 ; 277: 41580-41589
25. Xu Y, Huang S, Liu Z-G, Han J. Poly(ADP-ribose)Polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem. 2006 ; 281: 8788-8795 (Pubitemid 43847985)
26. Ithier C, Labelle Y, Poirier GG. PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells. Apoptosis. 2007 ; 12: 2037-2049 (Pubitemid 47498234)
27. Kauppinen TM, Chan WY, Suh SW, Wiggins AK, Huang EJ, Swanson RA. Direct phosphorylation and regulation of poly(ADP-ribose)polymerase-1 by extracellular signal-regulated kinases 1/2. PNAS. 2006 ; 103: 7136-7141
28. Chang F, Steelman LS, Lee JT, et al. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia. 2003 ; 17: 1263-1293 (Pubitemid 36857335)
29. Gupta S, Barrett T, Whitmarsh AJ, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996 ; 15: 2760-2770 (Pubitemid 26176253)
30. Ha HC, Hester LD, Snyder SH. Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. PNAS. 2002 ; 99: 3270-3275 (Pubitemid 34240621)
31. Buday L, Egan SE, Rodriguez VP, Cantrell DA, Downward J. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J Biol Chem. 1994 ; 269: 9019-9023 (Pubitemid 24209221)
32. Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ, Stone JC. RasGRP, a Ras guanil nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science. 1998 ; 280: 1082-1086 (Pubitemid 28234950)
33. Dower NA, Stang SL, Bottorff DA, et al. Ras GRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol. 2000 ; 1: 317-321
34. Geyer M, Wittinghofer A. GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr Opin Struct Biol. 1997 ; 7: 786-792 (Pubitemid 28025104)
35. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol. 2005 ; 25: 4426-4441 (Pubitemid 40705750)
36. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol. 2007 ; 27: 2732-2745 (Pubitemid 46581361)
37. Zheng Y, Zha Y, Gajewski TF. Molecular regulation of T-cell anergy. EMBO Reports. 2008 ; 9: 50-55
38. Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002 ; 29: 288-291 (Pubitemid 34118775)
39. Petri M, Buyon J, Kim M. Classification and definition of major flares in SLE clinical trials. Lupus. 1999 ; 8: 685-691 (Pubitemid 29520536)
40. Dixon WJ BMDP Statistical Software. Los Angeles, California: University of California Press ; 1993 :
41. Das J, Ho M, Zikherman J, et al. Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell. 2009 ; 136: 337-351
42. Hedin KE, Bell MP, Huntoon CJ, Karnitz LM, McKean DJ. Gi proteins use a novel βγ- and Ras-independent pathway to activate Extracellular signal-Regulated Kinase and mobilize AP-1 transcription factors in Jurkat T Lymphocytes. JBC. 1999 ; 274: 19992-20001
43. Kauppinen TM, Chan WY, Suh SW, Wiggins AK, Huang EJ, Swanson RA. Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. PNAS. 2006 ; 103: 7136-7141
44. Kang SJ, Kim BM, Lee YJ, Hong SH, Chung HW. Titanium dioxide nanoparticles induce apoptosis through the JNK/p38-caspase-8-Bid pathway in phytohemagglutinin-stimulated human lymphocytes. Biochem Biophys Res Comm. 2009 ; 386: 682-687
45. Norbury CJ, Zhivotovsky B. DNA damage-induced apoptosis. Oncogene. 2004 ; 23: 2797-2808 (Pubitemid 38638843)