TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population

Lupus

Volumn 19, Issue 10, 2010, Pages 1181-1186

  He, C F ^a,b   Liu, Y S ^a,b   Cheng, Y L ^b   Gao, J P ^a,b   Pan, T M ^a,b   Han, J W ^a,b   Quan, C ^a,b   Sun, L D ^a,b   Zheng, H F ^a,b   Zuo, X B ^a,b   Xu, S X ^a,b   Sheng, Y J ^a,b   Yao, S ^a,b   Hu, W L ^a,b   Li, Y ^a,b   Yu, Z Y ^a,b   Yin, X Y ^a,b   Zhang, X J ^a,b   Cui, Y ^a,b   Yang, S ^a,b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Chinese Han population; susceptibility gene; systemic lupus erythematosus

Indexed keywords

ANTINUCLEAR ANTIBODY; ETS1 PROTEIN; IKZF1 PROTEIN; PROTEIN; RASGRP3 PROTEIN; SLC15A4 PROTEIN; TNIP1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTHRITIS; ARTICLE; CHINESE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HEMATOLOGIC DISEASE; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MOUTH ULCER; NEUROLOGIC DISEASE; PHENOTYPE; PHOTOSENSITIVITY; PRIORITY JOURNAL; RASH; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; VASCULITIS;

ADULT; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; CARRIER PROTEINS; CHINA; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IKAROS TRANSCRIPTION FACTOR; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEIN C-ETS-1;

EID: 77956261467     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203310367918     Document Type: Article

References (28)

1. Nath SK, Kilpatrick J., Harley JB Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin Immunol 2004 ; 16: 794-800.
2. Danchenko N., Satia JA, Anthony MS Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus 2006 ; 15: 308-318.
3. Zeng QY, Chen R., Darmawan J., et al. Rheumatic diseases in China. Arthritis Res Ther 2008 ; 10: R17.
4. Graham RR, Cotsapas C., Davies L., et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 2008 ; 40: 1059-1061.
5. Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008 ; 40: 204-210.
6. Hom G., Graham RR, Modrek B., et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008 ; 358: 900-909.
7. Kozyrev SV, Abelson AK, Wojcik J., et al. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nat Genet 2008 ; 40: 211-216.
8. Han JW, Zheng HF, Cui Y., et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009 ; 361: 2609-2618.
9. Gateva V., Sandling JK, Hom G., et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 2009 ; 41: 1228-1233.
10. Taylor KE, Remmers EF, Lee AT, et al. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet 2008 ; 4: e1000084.
11. Cai LQ, Wang ZX, Lu WS, et al. A single-nucleotide polymorphism of the TNFAIP3 gene is associated with systemic lupus erythematosus in Chinese Han population. Mol Biol Rep 2010 ; 37: 389-394.
12. Hochberg MC Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997 ; 40: 1725.
13. Purcell S., Neale B., Todd-Brown K., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007 ; 81: 559-575.
14. Mauro C., Pacifico F., Lavorgna A., et al. ABIN-1 binds to NEMO/ IKKgamma and co-operates with A20 in inhibiting NF-kappaB. J Biol Chem 2006 ; 281: 18482-18488.
15. Musone SL, Taylor KE, Lu TT, et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet 2008 ; 40: 1062-1064.
16. Nair RP, Duffin KC, Helms C., et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 2009 ; 41: 199-204.
17. Lee J., Tattoli I., Wojtal KA, Vavricka SR, Philpott DJ, Girardin SE pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem 2009 ; 284: 23818-23829.
18. Gallant S., Gilkeson G. ETS transcription factors and regulation of immunity. Arch Immunol Ther Exp (Warsz) 2006 ; 54: 149-163.
19. Bories JC, Willerford DM, Grevin D., et al. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature 1995 ; 377: 635-638.
20. Stone JC Regulation of Ras in lymphocytes: get a GRP. Biochem Soc Trans 2006 ; 34: 858-861.
21. Coughlin JJ, Stang SL, Dower NA, Stone JC The role of RasGRPs in regulation of lymphocyte proliferation. Immunol Lett 2006 ; 105: 77-82.
22. Coughlin JJ, Stang SL, Dower NA, Stone JC RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol 2005 ; 175: 7179-7184.
23. Nera KP, Alinikula J., Terho P., et al. Ikaros has a crucial role in regulation of B cell receptor signaling. Eur J Immunol 2006 ; 36: 516-525.
24. Yap WH, Yeoh E., Tay A., Brenner S., Venkatesh B. STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells. FEBS Lett 2005 ; 579: 4470-4478.
25. Plenge RM, Padyukov L., Remmers EF, et al. Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet 2005 ; 77: 1044-1060.
26. Lee AT, Li W., Liew A., et al. The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status. Genes Immun 2005 ; 6: 129-133.
27. Kawasaki A., Ito I., Hikami K., et al. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Arthritis Res Ther 2008 ; 10: R113.
28. Thorburn CM, Prokunina-Olsson L., Sterba KA, et al. Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort. Genes Immun 2007 ; 8: 279-287.