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Volumn 15, Issue 3, 2014, Pages 240-255

CPP mediated insulin delivery: Current status and promising future

Author keywords

Bioavailability; Cell penetrating peptide; Insulin; Nonparenteral administration

Indexed keywords

CELL PENETRATING PEPTIDE; INSULIN; MORPHOLINO OLIGONUCLEOTIDE; NANOPARTICLE; PENETRATIN; POLYMER; SOLID LIPID NANOPARTICLE; TRANSACTIVATOR PROTEIN; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALPHA INTERFERON; BETA CYCLODEXTRIN; CHYMOTRYPSIN; CHYMOTRYPSIN A; DEXTRAN; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; LEUPRORELIN; LIPID NANOPARTICLE; LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE; OLIGOARGININE; POLYARGININE; PROTAMINE; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT;

EID: 84907342376     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/1389201015666140813125840     Document Type: Article
Times cited : (9)

References (102)
  • 3
    • 84907353130 scopus 로고    scopus 로고
    • Novel carrier systems for oral delivery of insulin
    • Shinde, P.V. Novel carrier systems for oral delivery of insulin. Asian J. Pharm. Tech. Innov., 2013, 1(02), 01-09.
    • (2013) Asian J. Pharm. Tech. Innov , vol.1 , Issue.2 , pp. 01-09
    • Shinde, P.V.1
  • 4
    • 36248965689 scopus 로고    scopus 로고
    • Current challenges in non-invasive insulin delivery systems: A comparative review
    • Khafagy, E.S.; Morishita, M.; Onuki, Y.; Takayama, K. Current challenges in non-invasive insulin delivery systems: A comparative review. Adv. Drug. Delivery. Rev., 2007, 59(15), 1521-1546.
    • (2007) Adv. Drug. Delivery. Rev , vol.59 , Issue.15 , pp. 1521-1546
    • Khafagy, E.S.1    Morishita, M.2    Onuki, Y.3    Takayama, K.4
  • 5
    • 4344640503 scopus 로고    scopus 로고
    • The physiological rationale for oral insulin administration
    • Arbit, E. The physiological rationale for oral insulin administration. Diabetes Technol. Ther., 2004, 6(4), 510-517.
    • (2004) Diabetes Technol. Ther , vol.6 , Issue.4 , pp. 510-517
    • Arbit, E.1
  • 6
    • 84863510349 scopus 로고    scopus 로고
    • An overview of natural polymers for oral insulin delivery
    • Sonia, T.; Sharma, C.P. An overview of natural polymers for oral insulin delivery. Drug Discov. Today, 2012, 17(13), 784-792.
    • (2012) Drug Discov. Today , vol.17 , Issue.13 , pp. 784-792
    • Sonia, T.1    Sharma, C.P.2
  • 7
    • 84857531754 scopus 로고    scopus 로고
    • Insulin versus lipid emulsion in a rabbit model of severe propranolol toxicity: A pilot study
    • article ID 361737
    • Harvey, M.; Cave, G.; Lahner, D.; Desmet, J.; Prince, G.; Hopgood, G. Insulin versus lipid emulsion in a rabbit model of severe propranolol toxicity: a pilot study. Crit. Care Res. Pract., 2011, article ID 361737.
    • (2011) Crit. Care Res. Pract
    • Harvey, M.1    Cave, G.2    Lahner, D.3    Desmet, J.4    Prince, G.5    Hopgood, G.6
  • 8
    • 84862833264 scopus 로고    scopus 로고
    • Liposomes containing glycocholate as potential oral insulin delivery systems: Preparation, in vitro characterization, and improved protection against enzymatic degradation
    • Niu, M.; Lu, Y.; Hovgaard, L.; Wu, W. Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation. Int. J. Nanomedicine, 2011, 6, 1155-1166.
    • (2011) Int. J. Nanomedicine , vol.6 , pp. 1155-1166
    • Niu, M.1    Lu, Y.2    Hovgaard, L.3    Wu, W.4
  • 9
    • 79960480209 scopus 로고    scopus 로고
    • Insulin-loaded SLN prepared with the emulsion dilution technique: In vivo tracking of nanoparticles after oral administration to rats
    • Trotta, M.; Carlotti, M.; Gallarate, M.; Zara, G.; Muntoni, E.; Battaglia, L. Insulin-loaded SLN prepared with the emulsion dilution technique: in vivo tracking of nanoparticles after oral administration to rats. J. Dispers. Sci. Technol., 2011, 32(7), 1041-1045.
    • (2011) J. Dispers. Sci. Technol , vol.32 , Issue.7 , pp. 1041-1045
    • Trotta, M.1    Carlotti, M.2    Gallarate, M.3    Zara, G.4    Muntoni, E.5    Battaglia, L.6
  • 12
    • 84892724171 scopus 로고    scopus 로고
    • Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation
    • Soltani-Arabshahi, R.; Wong, J.W.; Duffy, K.L.; Powell, D.L. Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation. JAMA Dermatol., 2014, 150(1), 68-72.
    • (2014) JAMA Dermatol , vol.150 , Issue.1 , pp. 68-72
    • Soltani-Arabshahi, R.1    Wong, J.W.2    Duffy, K.L.3    Powell, D.L.4
  • 13
    • 84874945035 scopus 로고    scopus 로고
    • Approaches for enhancing oral bioavailability of peptides and proteins
    • Renukuntla, J.; Vadlapudi, A.D.; Patel, A.; Boddu, S.H.; Mitra, A.K. Approaches for enhancing oral bioavailability of peptides and proteins. Int. J. Pharm., 2013, 447(1), 75-93.
    • (2013) Int. J. Pharm , vol.447 , Issue.1 , pp. 75-93
    • Renukuntla, J.1    Vadlapudi, A.D.2    Patel, A.3    Boddu, S.H.4    Mitra, A.K.5
  • 15
    • 33748960636 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of a novel oral insulin formulation1
    • MA, H.; LIU, Z.; Zheng, C.X. In vitro and in vivo evaluation of a novel oral insulin formulation1. Acta. Pharmacol. Sin., 2006, 27(10), 1382-1388.
    • (2006) Acta. Pharmacol. Sin , vol.27 , Issue.10 , pp. 1382-1388
    • Ma, H.1    Liu, Z.2    Zheng, C.X.3
  • 16
    • 84862828348 scopus 로고    scopus 로고
    • Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration
    • Zhang, X.; Sun, M.; Zheng, A.; Cao, D.; Bi, Y.; Sun, J. Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration. Eur. J. Pharm. Sci., 2012, 45(5), 632-638.
    • (2012) Eur. J. Pharm. Sci , vol.45 , Issue.5 , pp. 632-638
    • Zhang, X.1    Sun, M.2    Zheng, A.3    Cao, D.4    Bi, Y.5    Sun, J.6
  • 17
    • 30844445734 scopus 로고    scopus 로고
    • Rectal and vaginal administration of insulin-chitosan formulations: An experimental study in rabbits
    • Degim, Z.; Degim, T.; Acartürk, F.; Erdogan, D.; Özogul, C.; Köksal, M. Rectal and vaginal administration of insulin-chitosan formulations: An experimental study in rabbits. J. Drug Target, 2005, 13(10), 563-572.
    • (2005) J. Drug Target , vol.13 , Issue.10 , pp. 563-572
    • Degim, Z.1    Degim, T.2    Acartürk, F.3    Erdogan, D.4    Özogul, C.5    Köksal, M.6
  • 18
    • 84907300671 scopus 로고    scopus 로고
    • Oral Delivery of Insulin: Novel Approaches
    • Elsayed, A.M. Oral Delivery of Insulin: Novel Approaches. 2012.
    • (2012)
    • Elsayed, A.M.1
  • 19
    • 35848959714 scopus 로고    scopus 로고
    • Alginate/chitosan nanoparticles are effective for oral insulin delivery
    • Sarmento, B.; Ribeiro, A.; Veiga, F.; Sampaio, P.; Neufeld, R.; Ferreira, D. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm. Res., 2007, 24(12), 2198-2206.
    • (2007) Pharm. Res , vol.24 , Issue.12 , pp. 2198-2206
    • Sarmento, B.1    Ribeiro, A.2    Veiga, F.3    Sampaio, P.4    Neufeld, R.5    Ferreira, D.6
  • 20
    • 76749103819 scopus 로고    scopus 로고
    • Enteric-coated capsules filled with freeze-dried chitosan/poly (γ-glutamic acid) nanoparticles for oral insulin delivery
    • Sonaje, K.; Chen, Y.J.; Chen, H.L.; Wey, S.P.; Juang, J.H.; Nguyen, H.N.; Hsu, C.W.; Lin, K.J.; Sung, H.W. Enteric-coated capsules filled with freeze-dried chitosan/poly (γ-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials, 2010, 31(12), 3384-3394.
    • (2010) Biomaterials , vol.31 , Issue.12 , pp. 3384-3394
    • Sonaje, K.1    Chen, Y.J.2    Chen, H.L.3    Wey, S.P.4    Juang, J.H.5    Nguyen, H.N.6    Hsu, C.W.7    Lin, K.J.8    Sung, H.W.9
  • 21
    • 84855967689 scopus 로고    scopus 로고
    • Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery
    • Su, F.Y.; Lin, K.J.; Sonaje, K.; Wey, S.P.; Yen, T.C.; Ho, Y.C.; Panda, N.; Chuang, E.Y.; Maiti, B.; Sung, H.W. Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery. Biomaterials, 2012, 33(9), 2801-2811.
    • (2012) Biomaterials , vol.33 , Issue.9 , pp. 2801-2811
    • Su, F.Y.1    Lin, K.J.2    Sonaje, K.3    Wey, S.P.4    Yen, T.C.5    Ho, Y.C.6    Panda, N.7    Chuang, E.Y.8    Maiti, B.9    Sung, H.W.10
  • 22
    • 75749129504 scopus 로고    scopus 로고
    • Novel solid lipid nanoparticles as carriers for oral administration of insulin
    • Zhang, Z.; Lv, H.; Zhou, J. Novel solid lipid nanoparticles as carriers for oral administration of insulin. Die. Pharmazie. - An Int. J. Pharm. Sci, 2009, 64(9), 574-578.
    • (2009) Die. Pharmazie. - An Int. J. Pharm. Sci , vol.64 , Issue.9 , pp. 574-578
    • Zhang, Z.1    Lv, H.2    Zhou, J.3
  • 23
    • 84870361288 scopus 로고    scopus 로고
    • Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin
    • Zhang, Z.H.; Zhang, Y.L.; Zhou, J.P.; Lv, H.X. Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin. Int. J. Nanomedicine, 2012, 7, 3333-3339.
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 3333-3339
    • Zhang, Z.H.1    Zhang, Y.L.2    Zhou, J.P.3    Lv, H.X.4
  • 25
    • 84863099046 scopus 로고    scopus 로고
    • Cell-penetrating peptides: Breaking through to the other side
    • Koren, E.; Torchilin, V.P. Cell-penetrating peptides: Breaking through to the other side. Trends Mol. Med., 2012, 18(7), 385-393.
    • (2012) Trends Mol. Med , vol.18 , Issue.7 , pp. 385-393
    • Koren, E.1    Torchilin, V.P.2
  • 26
    • 84864631153 scopus 로고    scopus 로고
    • Cell-penetrating peptides: Classes, origin, and current landscape
    • Milletti, F. Cell-penetrating peptides: Classes, origin, and current landscape. Drug Discov. Today, 2012, 17(15), 850-860.
    • (2012) Drug Discov. Today , vol.17 , Issue.15 , pp. 850-860
    • Milletti, F.1
  • 27
    • 57349182296 scopus 로고    scopus 로고
    • Effect of cell-penetrating peptides on the nasal absorption of insulin
    • Khafagy, E.S.; Morishita, M.; Isowa, K.; Imai, J.; Takayama, K. Effect of cell-penetrating peptides on the nasal absorption of insulin. J. Control. Release, 2009, 133(2), 103-108.
    • (2009) J. Control. Release , vol.133 , Issue.2 , pp. 103-108
    • Khafagy, E.S.1    Morishita, M.2    Isowa, K.3    Imai, J.4    Takayama, K.5
  • 28
    • 33847281527 scopus 로고    scopus 로고
    • A novel approach using functional peptides for efficient intestinal absorption of insulin
    • Morishita, M.; Kamei, N.; Ehara, J.; Isowa, K.; Takayama, K. A novel approach using functional peptides for efficient intestinal absorption of insulin. J. Control. Release, 2007, 118(2), 177-184.
    • (2007) J. Control. Release , vol.118 , Issue.2 , pp. 177-184
    • Morishita, M.1    Kamei, N.2    Ehara, J.3    Isowa, K.4    Takayama, K.5
  • 30
    • 54849439914 scopus 로고    scopus 로고
    • Usefulness of cell-penetrating peptides to improve intestinal insulin absorption
    • Kamei, N.; Morishita, M.; Eda, Y.; Ida, N.; Nishio, R.; Takayama, K. Usefulness of cell-penetrating peptides to improve intestinal insulin absorption. J. Control. Release, 2008, 132(1), 21-25.
    • (2008) J. Control. Release , vol.132 , Issue.1 , pp. 21-25
    • Kamei, N.1    Morishita, M.2    Eda, Y.3    Ida, N.4    Nishio, R.5    Takayama, K.6
  • 31
    • 84859720244 scopus 로고    scopus 로고
    • Oral biodrug delivery using cellpenetrating peptide
    • Khafagy, E.S.; Morishita, M. Oral biodrug delivery using cellpenetrating peptide. Adv. Drug Delivery Rev., 2012, 64(6), 531-539.
    • (2012) Adv. Drug Delivery Rev , vol.64 , Issue.6 , pp. 531-539
    • Khafagy, E.S.1    Morishita, M.2
  • 32
    • 84874584382 scopus 로고    scopus 로고
    • Noninvasive insulin delivery: The great potential of cell-penetrating peptides
    • Kamei, N.; Nielsen, E.J.B.; Khafagy, E.S.; Morishita, M. Noninvasive insulin delivery: the great potential of cell-penetrating peptides. Therapeut. Deliv., 2013, 4(3), 315-326.
    • (2013) Therapeut. Deliv , vol.4 , Issue.3 , pp. 315-326
    • Kamei, N.1    Nielsen, E.J.B.2    Khafagy, E.S.3    Morishita, M.4
  • 33
    • 77952887464 scopus 로고    scopus 로고
    • Developing macromolecular therapeutics: The future drug-of-choice
    • He, H.; Dong, W.; Gong, J.; Wang, J.; Yang, V.C. Developing macromolecular therapeutics: the future drug-of-choice. Front. Chem. Sci. Eng., 2010, 4(1),10-17.
    • (2010) Front. Chem. Sci. Eng , vol.4 , Issue.1 , pp. 10-17
    • He, H.1    Dong, W.2    Gong, J.3    Wang, J.4    Yang, V.C.5
  • 34
    • 84900339062 scopus 로고    scopus 로고
    • COPA and SLC4A4 are required for cellular entry of arginine-rich peptides
    • Tsumuraya, T.; Matsushita, M. COPA and SLC4A4 are required for cellular entry of arginine-rich peptides. Plos One, 2014, 9(1), e86639.
    • (2014) Plos One , vol.9 , Issue.1
    • Tsumuraya, T.1    Matsushita, M.2
  • 35
    • 11844293998 scopus 로고    scopus 로고
    • The cationic cell-penetrating peptide CPPTAT derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: Optical, biophysical, and metabolic evidence
    • Ziegler, A.; Nervi, P.; Dürrenberger, M.; Seelig, J. The cationic cell-penetrating peptide CPPTAT derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence. Biochemistry, 2005, 44(1), 138-148.
    • (2005) Biochemistry , vol.44 , Issue.1 , pp. 138-148
    • Ziegler, A.1    Nervi, P.2    Dürrenberger, M.3    Seelig, J.4
  • 37
    • 77949890248 scopus 로고    scopus 로고
    • Cell penetrating peptides: Overview and applications to the delivery of oligonucleotides
    • Hassane, F.S.; Saleh, A.; Abes, R.; Gait, M.; Lebleu, B. Cell penetrating peptides: Overview and applications to the delivery of oligonucleotides. Cell Mol. Life Sci., 2010, 67(5), 715-726.
    • (2010) Cell Mol. Life Sci , vol.67 , Issue.5 , pp. 715-726
    • Hassane, F.S.1    Saleh, A.2    Abes, R.3    Gait, M.4    Lebleu, B.5
  • 38
    • 82555169705 scopus 로고    scopus 로고
    • The CPP Tat enhances eGFP cell internalization and transepithelial transport by the larval midgut of Bombyx mori (Lepidoptera, Bombycidae)
    • Cermenati, G.; Terracciano, I.; Castelli, I.; Giordana, B.; Rao, R.; Pennacchio, F.; Casartelli, M. The CPP Tat enhances eGFP cell internalization and transepithelial transport by the larval midgut of Bombyx mori (Lepidoptera, Bombycidae). J. Insect. Physiol., 2011, 57(12), 1689-1697.
    • (2011) J. Insect. Physiol , vol.57 , Issue.12 , pp. 1689-1697
    • Cermenati, G.1    Terracciano, I.2    Castelli, I.3    Giordana, B.4    Rao, R.5    Pennacchio, F.6    Casartelli, M.7
  • 39
    • 84880958999 scopus 로고    scopus 로고
    • The use of low molecular weight protamine chemical chimera to enhance monomeric insulin intestinal absorption
    • He, H.; Sheng, J.; David, A.E.; Kwon, Y.M.; Zhang, J.; Huang, Y.; Wang, J.; Yang, V.C. The use of low molecular weight protamine chemical chimera to enhance monomeric insulin intestinal absorption. Biomaterials, 2013, 34(31), 7733-7743.
    • (2013) Biomaterials , vol.34 , Issue.31 , pp. 7733-7743
    • He, H.1    Sheng, J.2    David, A.E.3    Kwon, Y.M.4    Zhang, J.5    Huang, Y.6    Wang, J.7    Yang, V.C.8
  • 40
    • 23944512155 scopus 로고    scopus 로고
    • Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency
    • Liang, J.F.; Yang, V.C. Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency. Biochem. Biophys. Res. Commun., 2005, 335(3), 734-738.
    • (2005) Biochem. Biophys. Res. Commun , vol.335 , Issue.3 , pp. 734-738
    • Liang, J.F.1    Yang, V.C.2
  • 41
    • 64649092671 scopus 로고    scopus 로고
    • Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin
    • Patel, L.N.; Wang, J.; Kim, K.J.; Borok, Z.; Crandall, E.D.; Shen, W.C. Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Mol. Pharm., 2009, 6(2), 492-503.
    • (2009) Mol. Pharm , vol.6 , Issue.2 , pp. 492-503
    • Patel, L.N.1    Wang, J.2    Kim, K.J.3    Borok, Z.4    Crandall, E.D.5    Shen, W.C.6
  • 42
    • 0033119594 scopus 로고    scopus 로고
    • Low molecular weight protamine: A potential nontoxic heparin antagonist
    • Byun, Y.; Singh, V.K.; Yang, V.C. Low molecular weight protamine: A potential nontoxic heparin antagonist. Thromb. Res., 1999, 94(1), 53-61.
    • (1999) Thromb. Res , vol.94 , Issue.1 , pp. 53-61
    • Byun, Y.1    Singh, V.K.2    Yang, V.C.3
  • 43
    • 34548840911 scopus 로고
    • The effect of zinc salts on the action of insulin
    • Scott, D.; Fisher, A. The effect of zinc salts on the action of insulin. J. Pharmacol. Exp. Ther., 1935, 55(2), 206-221.
    • (1935) J. Pharmacol. Exp. Ther , vol.55 , Issue.2 , pp. 206-221
    • Scott, D.1    Fisher, A.2
  • 46
    • 0035279632 scopus 로고    scopus 로고
    • Reduced reactivity towards anti-protamine antibodies of a low molecular weight protamine analogue
    • Tsui, B.; Singh, V.K.; Liang, J.F.; Yang, V.C. Reduced reactivity towards anti-protamine antibodies of a low molecular weight protamine analogue. Thromb. Res., 2001, 101(5), 417-420.
    • (2001) Thromb. Res , vol.101 , Issue.5 , pp. 417-420
    • Tsui, B.1    Singh, V.K.2    Liang, J.F.3    Yang, V.C.4
  • 47
    • 0011967676 scopus 로고    scopus 로고
    • Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (I): Preparation and characterization
    • Chang, L.C.; Lee, H.F.; Yang, Z.; Yang, V.C. Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (I): Preparation and characterization. AAPS PharmSci., 2001, 3(3), 7-14.
    • (2001) AAPS PharmSci , vol.3 , Issue.3 , pp. 7-14
    • Chang, L.C.1    Lee, H.F.2    Yang, Z.3    Yang, V.C.4
  • 48
    • 0035783151 scopus 로고    scopus 로고
    • Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (II): In vitro evaluation of efficacy and toxicity
    • Chang, L.C.; Liang, J.F.; Lee, H.F.; Lee, L.M.; Yang, V.C. Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (II): In vitro evaluation of efficacy and toxicity. AAPS Pharm. Sci., 2001, 3(3), 15-23.
    • (2001) AAPS Pharm. Sci , vol.3 , Issue.3 , pp. 15-23
    • Chang, L.C.1    Liang, J.F.2    Lee, H.F.3    Lee, L.M.4    Yang, V.C.5
  • 49
    • 33845461883 scopus 로고    scopus 로고
    • Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): Preliminary in vivo evaluation of efficacy and toxicity using a canine model
    • Chang, L.C.; Wrobleski, S.; Wakefield, T.W.; Lee, L.M.; Yang, V.C. Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): Preliminary in vivo evaluation of efficacy and toxicity using a canine model. AAPS PharmSci., 2001, 3(3), 24-31.
    • (2001) AAPS PharmSci , vol.3 , Issue.3 , pp. 24-31
    • Chang, L.C.1    Wrobleski, S.2    Wakefield, T.W.3    Lee, L.M.4    Yang, V.C.5
  • 50
    • 24644512176 scopus 로고    scopus 로고
    • Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: In vitro and in vivo study
    • Park, Y.J.; Chang, L.C.; Liang, J.F.; Moon, C.; Chung, C.P.; Yang, V.C. Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: In vitro and in vivo study. FASEB J., 2005, 19(11), 1555-1557.
    • (2005) FASEB J , vol.19 , Issue.11 , pp. 1555-1557
    • Park, Y.J.1    Chang, L.C.2    Liang, J.F.3    Moon, C.4    Chung, C.P.5    Yang, V.C.6
  • 51
    • 53049085052 scopus 로고    scopus 로고
    • Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery
    • Kamei, N.; Morishita, M.; Ehara, J.; Takayama, K. Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery. J. Control. Release, 2008, 131(2), 94-99.
    • (2008) J. Control. Release , vol.131 , Issue.2 , pp. 94-99
    • Kamei, N.1    Morishita, M.2    Ehara, J.3    Takayama, K.4
  • 52
    • 84859643885 scopus 로고    scopus 로고
    • The agony of choice: How to find a suitable CPP for cargo delivery
    • Müller, J.; Triebus, J.; Kretzschmar, I.; Volkmer, R.; Boisguerin, P. The agony of choice: how to find a suitable CPP for cargo delivery. J. Pept. Sci., 2012, 18(5), 293-301.
    • (2012) J. Pept. Sci , vol.18 , Issue.5 , pp. 293-301
    • Müller, J.1    Triebus, J.2    Kretzschmar, I.3    Volkmer, R.4    Boisguerin, P.5
  • 53
    • 84881258428 scopus 로고    scopus 로고
    • Potent and prolonged hypoglycemic activity of an oral insulin-Tat mixture in diabetic mice
    • Manosroi, J.; Tangjai, T.; Werner, R.; Götz, F.; Manosroi, W.; Manosroi, A. Potent and prolonged hypoglycemic activity of an oral insulin-Tat mixture in diabetic mice. Drug Res., 2013, 63(7), 351-356.
    • (2013) Drug Res , vol.63 , Issue.7 , pp. 351-356
    • Manosroi, J.1    Tangjai, T.2    Werner, R.3    Götz, F.4    Manosroi, W.5    Manosroi, A.6
  • 54
    • 2342476860 scopus 로고    scopus 로고
    • Low molecular weight protamine as an efficient and nontoxic gene carrier: In vitro study
    • Park, Y.J.; Liang, J.F.; Ko, K.S.; Kim, S.W.; Yang, V.C. Low molecular weight protamine as an efficient and nontoxic gene carrier: in vitro study. J. Gene Med., 2003, 5(8), 700-711.
    • (2003) J. Gene Med , vol.5 , Issue.8 , pp. 700-711
    • Park, Y.J.1    Liang, J.F.2    Ko, K.S.3    Kim, S.W.4    Yang, V.C.5
  • 56
    • 80755126054 scopus 로고    scopus 로고
    • Low molecular weight protamine/insulin formulation with potential to attenuate protamine-masqueraded insulin allergy
    • He, H.; David, A.E.; Zhang, J.; Park, Y.S.; Wang, J.; Huang, Y.; Wang, J.; Yang, V.C. Low molecular weight protamine/insulin formulation with potential to attenuate protamine-masqueraded insulin allergy. Macromol, Res., 2011, 19(12), 1224-1226.
    • (2011) Macromol, Res , vol.19 , Issue.12 , pp. 1224-1226
    • He, H.1    David, A.E.2    Zhang, J.3    Park, Y.S.4    Wang, J.5    Huang, Y.6    Wang, J.7    Yang, V.C.8
  • 57
    • 67349268446 scopus 로고    scopus 로고
    • Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides
    • Kamei, N.; Morishita, M.; Takayama, K. Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides. J. Control. Release, 2009, 136(3), 179-186.
    • (2009) J. Control. Release , vol.136 , Issue.3 , pp. 179-186
    • Kamei, N.1    Morishita, M.2    Takayama, K.3
  • 58
    • 81255157835 scopus 로고    scopus 로고
    • Improving intestinal insulin absorption efficiency through coadministration of cellpenetrating peptide and hydroxypropyl-β-cyclodextrin
    • Zhang, L.; Song, L.; Zhang, C.; Ren, Y. Improving intestinal insulin absorption efficiency through coadministration of cellpenetrating peptide and hydroxypropyl-β-cyclodextrin. Carbohydr. Polym., 2012, 87(2), 1822-1827.
    • (2012) Carbohydr. Polym , vol.87 , Issue.2 , pp. 1822-1827
    • Zhang, L.1    Song, L.2    Zhang, C.3    Ren, Y.4
  • 59
    • 77952239068 scopus 로고    scopus 로고
    • Structural requirements of penetratin absorption enhancement efficiency for insulin delivery
    • Khafagy, E.S.; Morishita, M.; Ida, N.; Nishio, R.; Isowa, K.; Takayama, K. Structural requirements of penetratin absorption enhancement efficiency for insulin delivery. J. Control. Release, 2010, 143(3), 302-310.
    • (2010) J. Control. Release , vol.143 , Issue.3 , pp. 302-310
    • Khafagy, E.S.1    Morishita, M.2    Ida, N.3    Nishio, R.4    Isowa, K.5    Takayama, K.6
  • 60
    • 76549110719 scopus 로고    scopus 로고
    • The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides
    • Khafagy, E.S.; Morishita, M.; Takayama, K. The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides. Int. J. Pharm., 2010, 388(1), 209-212.
    • (2010) Int. J. Pharm , vol.388 , Issue.1 , pp. 209-212
    • Khafagy, E.S.1    Morishita, M.2    Takayama, K.3
  • 61
    • 84872497161 scopus 로고    scopus 로고
    • Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organizing maps
    • Kamei, N.; Kikuchi, S.; Morishita, M.; Terasawa, Y.; Yasuda, A.; Yamamoto, S.; Ida, N.; Nishio, R.; Takayama, K. Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organizing maps. J. Pharm. Sci., 2013, 102(2), 469-479.
    • (2013) J. Pharm. Sci , vol.102 , Issue.2 , pp. 469-479
    • Kamei, N.1    Kikuchi, S.2    Morishita, M.3    Terasawa, Y.4    Yasuda, A.5    Yamamoto, S.6    Ida, N.7    Nishio, R.8    Takayama, K.9
  • 62
    • 50849144942 scopus 로고    scopus 로고
    • Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery
    • Torchilin, V. P. Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Peptide Sci., 2008, 90(5), 604-610.
    • (2008) Peptide Sci , vol.90 , Issue.5 , pp. 604-610
    • Torchilin, V.P.1
  • 63
    • 84907300868 scopus 로고    scopus 로고
    • Co-administration with cell penetrating peptide enhances the oral bioavailability of docetaxelloaded nanoparticles
    • Bu, X.; Zhu, T.; Ma, Y.; Shen, Q. Co-administration with cell penetrating peptide enhances the oral bioavailability of docetaxelloaded nanoparticles. Drug Dev. Ind. Pharm., 2014, 1-8.
    • (2014) Drug Dev. Ind. Pharm , pp. 1-8
    • Bu, X.1    Zhu, T.2    Ma, Y.3    Shen, Q.4
  • 64
    • 53149128040 scopus 로고    scopus 로고
    • Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape
    • El-Sayed, A.; Khalil, I.A.; Kogure, K.; Futaki, S.; Harashima, H. Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape. J. Biol. Chem., 2008, 283(34), 23450-23461.
    • (2008) J. Biol. Chem , vol.283 , Issue.34 , pp. 23450-23461
    • El-Sayed, A.1    Khalil, I.A.2    Kogure, K.3    Futaki, S.4    Harashima, H.5
  • 65
    • 21144447321 scopus 로고    scopus 로고
    • Transport Of Surface-Modified Nanoparticles Through Cell Monolayers
    • Koch, A.M.; Reynolds, F.; Merkle, H.P.; Weissleder, R.; Josephson, L. Transport Of Surface-Modified Nanoparticles Through Cell Monolayers. Chembiochem, 2005, 6(2), 337-345.
    • (2005) Chembiochem , vol.6 , Issue.2 , pp. 337-345
    • Koch, A.M.1    Reynolds, F.2    Merkle, H.P.3    Weissleder, R.4    Josephson, L.5
  • 66
    • 80054088405 scopus 로고    scopus 로고
    • Low molecular weight protaminefunctionalized nanoparticles for drug delivery to the brain after intranasal administration
    • Xia, H.; Gao, X.; Gu, G.; Liu, Z.; Zeng, N.; Hu, Q.; Song, Q.; Yao, L.; Pang, Z.; Jiang, X. Low molecular weight protaminefunctionalized nanoparticles for drug delivery to the brain after intranasal administration. Biomaterials, 2011, 32(36), 9888-9898.
    • (2011) Biomaterials , vol.32 , Issue.36 , pp. 9888-9898
    • Xia, H.1    Gao, X.2    Gu, G.3    Liu, Z.4    Zeng, N.5    Hu, Q.6    Song, Q.7    Yao, L.8    Pang, Z.9    Jiang, X.10
  • 67
    • 84877791708 scopus 로고    scopus 로고
    • Cell-penetrating peptide-modified plga nanoparticles for enhanced nose-to-brain macromolecular delivery
    • Yan, L.; Wang, H.; Jiang, Y.; Liu, J.; Wang, Z.; Yang, Y.; Huang, S.; Huang, Y. Cell-penetrating peptide-modified plga nanoparticles for enhanced nose-to-brain macromolecular delivery. Macromol. Res., 2013, 21(4), 435-441.
    • (2013) Macromol. Res , vol.21 , Issue.4 , pp. 435-441
    • Yan, L.1    Wang, H.2    Jiang, Y.3    Liu, J.4    Wang, Z.5    Yang, Y.6    Huang, S.7    Huang, Y.8
  • 68
    • 84875913755 scopus 로고    scopus 로고
    • Oligoarginine-modified biodegradable nanoparticles improve the intestinal absorption of insulin
    • Liu, X.; Liu, C.; Zhang, W.; Xie, C.; Wei, G.; Lu, W. Oligoarginine-modified biodegradable nanoparticles improve the intestinal absorption of insulin. Int. J. Pharm., 2013, 448(1), 159-167.
    • (2013) Int. J. Pharm , vol.448 , Issue.1 , pp. 159-167
    • Liu, X.1    Liu, C.2    Zhang, W.3    Xie, C.4    Wei, G.5    Lu, W.6
  • 69
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art
    • MuÈller, R.H.; MaÈder, K.; Gohla, S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art. Eur. J. Pharm. Biopharm., 2000, 50(1), 161-177.
    • (2000) Eur. J. Pharm. Biopharm , vol.50 , Issue.1 , pp. 161-177
    • Muèller, R.H.1    Maèder, K.2    Gohla, S.3
  • 70
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • Mehnert, W.; Mäder, K. Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev., 2001, 47(2), 165-196.
    • (2001) Adv. Drug Deliv. Rev , vol.47 , Issue.2 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 71
    • 84870356727 scopus 로고    scopus 로고
    • Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine
    • Chen, Y.; Yuan, L.; Zhou, L.; Zhang, Z.; Cao, W.; Wu, Q. Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine. Int. J. Nanomedicine, 2011, 7, 4581-4591.
    • (2011) Int. J. Nanomedicine , vol.7 , pp. 4581-4591
    • Chen, Y.1    Yuan, L.2    Zhou, L.3    Zhang, Z.4    Cao, W.5    Wu, Q.6
  • 72
    • 84867403685 scopus 로고    scopus 로고
    • Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by argininerich peptides
    • Tahara, Y.; Honda, S.; Kamiya, N.; Goto, M. Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by argininerich peptides. Med. Chem. Comm., 2012, 3(12), 1496-1499.
    • (2012) Med. Chem. Comm , vol.3 , Issue.12 , pp. 1496-1499
    • Tahara, Y.1    Honda, S.2    Kamiya, N.3    Goto, M.4
  • 73
    • 0037331715 scopus 로고    scopus 로고
    • Poly- L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro
    • Ohtake, K.; Maeno, T.; Ueda, H.; Natsume, H.; Morimoto, Y. Poly- L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro. Pharm. Res., 2003, 20(2), 153-160.
    • (2003) Pharm. Res , vol.20 , Issue.2 , pp. 153-160
    • Ohtake, K.1    Maeno, T.2    Ueda, H.3    Natsume, H.4    Morimoto, Y.5
  • 74
    • 33747589010 scopus 로고    scopus 로고
    • Review article: Polymer-matrix nanocomposites, processing, manufacturing, and application: An overview
    • Hussain, F.; Hojjati, M.; Okamoto, M.; Gorga, R.E. Review article: polymer-matrix nanocomposites, processing, manufacturing, and application: An overview. J. Compos. Mater., 2006, 40(17), 1511-1575.
    • (2006) J. Compos. Mater , vol.40 , Issue.17 , pp. 1511-1575
    • Hussain, F.1    Hojjati, M.2    Okamoto, M.3    Gorga, R.E.4
  • 75
    • 84870307914 scopus 로고    scopus 로고
    • Synthesis of TAT peptide-tagged PEGylated chitosan nanoparticles for siRNA delivery targeting neurodegenerative diseases
    • Malhotra, M.; Tomaro-Duchesneau, C.; Prakash, S. Synthesis of TAT peptide-tagged PEGylated chitosan nanoparticles for siRNA delivery targeting neurodegenerative diseases. Biomaterials, 2013, 34(4), 1270-1280.
    • (2013) Biomaterials , vol.34 , Issue.4 , pp. 1270-1280
    • Malhotra, M.1    Tomaro-Duchesneau, C.2    Prakash, S.3
  • 76
    • 84891790249 scopus 로고    scopus 로고
    • Penetratin derivative-based nanocomplexes for enhanced intestinal insulin delivery
    • Zhu, X.; Shan, W.; Zhang, P.; Jin, Y.; Guan, S.; Fan, T.; Yang, Y.; Zhou, Z.; Huang, Y. Penetratin derivative-based nanocomplexes for enhanced intestinal insulin delivery. Mol. Pharm., 2013, 11(1), 317-328.
    • (2013) Mol. Pharm , vol.11 , Issue.1 , pp. 317-328
    • Zhu, X.1    Shan, W.2    Zhang, P.3    Jin, Y.4    Guan, S.5    Fan, T.6    Yang, Y.7    Zhou, Z.8    Huang, Y.9
  • 77
    • 78651324058 scopus 로고    scopus 로고
    • Intracellular fates of cell-penetrating block copolypeptide vesicles
    • Sun, V.Z.; Li, Z.; Deming, T.J.; Kamei, D.T. Intracellular fates of cell-penetrating block copolypeptide vesicles. Biomacromolecules, 2010, 12(1), 10-13.
    • (2010) Biomacromolecules , vol.12 , Issue.1 , pp. 10-13
    • Sun, V.Z.1    Li, Z.2    Deming, T.J.3    Kamei, D.T.4
  • 78
    • 29844448699 scopus 로고    scopus 로고
    • Effects of poly-L-arginine on the permeation of hydrophilic compounds through surface ocular tissues
    • Nemoto, E.; Takahashi, H.; Kobayashi, D.; Ueda, H.; Morimoto, Y. Effects of poly-L-arginine on the permeation of hydrophilic compounds through surface ocular tissues. Biol. Pharm. Bull., 2006, 29(1), 155-160.
    • (2006) Biol. Pharm. Bull , vol.29 , Issue.1 , pp. 155-160
    • Nemoto, E.1    Takahashi, H.2    Kobayashi, D.3    Ueda, H.4    Morimoto, Y.5
  • 79
    • 34248674912 scopus 로고    scopus 로고
    • Effects of a sperminated gelatin on the nasal absorption of insulin
    • Seki, T.; Kanbayashi, H.; Chono, S.; Tabata, Y.; Morimoto, K. Effects of a sperminated gelatin on the nasal absorption of insulin. Int. J. Pharm., 2007, 338(1), 213-218.
    • (2007) Int. J. Pharm , vol.338 , Issue.1 , pp. 213-218
    • Seki, T.1    Kanbayashi, H.2    Chono, S.3    Tabata, Y.4    Morimoto, K.5
  • 80
    • 38349086145 scopus 로고    scopus 로고
    • Effects of sperminated polymers on the pulmonary absorption of insulin
    • Seki, T.; Fukushi, N.; Chono, S.; Morimoto, K. Effects of sperminated polymers on the pulmonary absorption of insulin. J. Control. Release, 2008, 125(3), 246-251.
    • (2008) J. Control. Release , vol.125 , Issue.3 , pp. 246-251
    • Seki, T.1    Fukushi, N.2    Chono, S.3    Morimoto, K.4
  • 84
    • 84870242534 scopus 로고    scopus 로고
    • Nanoparticle and targeted systems for cancer therapy
    • Brannon-Peppas, L.; Blanchette, J.O. Nanoparticle and targeted systems for cancer therapy. Adv. Drug Deliv. Rev., 2012, 64, 206-212.
    • (2012) Adv. Drug Deliv. Rev , vol.64 , pp. 206-212
    • Brannon-Peppas, L.1    Blanchette, J.O.2
  • 85
    • 0035207025 scopus 로고    scopus 로고
    • Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo
    • Lee, H.J.; Pardridge, W.M. Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo. Bioconjug. Chem., 2001, 12(6), 995-999.
    • (2001) Bioconjug. Chem , vol.12 , Issue.6 , pp. 995-999
    • Lee, H.J.1    Pardridge, W.M.2
  • 86
  • 88
    • 84859510563 scopus 로고    scopus 로고
    • The journey of a drug-carrier in the body: An anatomo-physiological perspective
    • Bertrand, N.; Leroux, J.C. The journey of a drug-carrier in the body: an anatomo-physiological perspective. J. Control. Release, 2012, 161(2), 152-163.
    • (2012) J. Control. Release , vol.161 , Issue.2 , pp. 152-163
    • Bertrand, N.1    Leroux, J.C.2
  • 90
    • 84868121994 scopus 로고    scopus 로고
    • PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy
    • Gu, G.; Xia, H.; Hu, Q.; Liu, Z.; Jiang, M.; Kang, T.; Miao, D.; Tu, Y.; Pang, Z.; Song, Q. PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy. Biomaterials, 2013, 34(1), 196-208.
    • (2013) Biomaterials , vol.34 , Issue.1 , pp. 196-208
    • Gu, G.1    Xia, H.2    Hu, Q.3    Liu, Z.4    Jiang, M.5    Kang, T.6    Miao, D.7    Tu, Y.8    Pang, Z.9    Song, Q.10
  • 92
    • 84888357305 scopus 로고    scopus 로고
    • One-month subchronic toxicity study of cell-penetrating peptides for insulin nasal delivery in rats
    • Khafagy, E.S.; Kamei, N.; Nielsen, E.J.B.; Nishio, R.; Morishita, M. One-month subchronic toxicity study of cell-penetrating peptides for insulin nasal delivery in rats. Eur. J. Pharm. Biopharm., 2013, 85(3), 736-743.
    • (2013) Eur. J. Pharm. Biopharm , vol.85 , Issue.3 , pp. 736-743
    • Khafagy, E.S.1    Kamei, N.2    Nielsen, E.J.B.3    Nishio, R.4    Morishita, M.5
  • 93
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • Vives, E.; Brodin, P.; Lebleu, B. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J. Biol. Chem., 1997, 272(25), 16010-16017.
    • (1997) J. Biol. Chem , vol.272 , Issue.25 , pp. 16010-16017
    • Vives, E.1    Brodin, P.2    Lebleu, B.3
  • 95
  • 96
    • 79953186583 scopus 로고    scopus 로고
    • How PEGylation enhances the stability and potency of insulin: A molecular dynamics simulation
    • Yang, C.; Lu, D.; Liu, Z. How PEGylation enhances the stability and potency of insulin: a molecular dynamics simulation. Biochemistry, 2011, 50(13), 2585-2593.
    • (2011) Biochemistry , vol.50 , Issue.13 , pp. 2585-2593
    • Yang, C.1    Lu, D.2    Liu, Z.3
  • 97
    • 70349198899 scopus 로고    scopus 로고
    • Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins
    • Khafagy, E.S.; Morishita, M.; Kamei, N.; Eda, Y.; Ikeno, Y.; Takayama, K. Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins. Int. J. Pharm., 2009, 381(1), 49-55.
    • (2009) Int. J. Pharm , vol.381 , Issue.1 , pp. 49-55
    • Khafagy, E.S.1    Morishita, M.2    Kamei, N.3    Eda, Y.4    Ikeno, Y.5    Takayama, K.6
  • 98
    • 84862221693 scopus 로고    scopus 로고
    • Poly (arginine) 8 enhanced intestinal absorption of insulin-loaded nanoparticles
    • Liu, X.; Zhang, W.; Wei, G.; Lu, W. [Poly (arginine) 8 enhanced intestinal absorption of insulin-loaded nanoparticles]. Yao xue xue bao= Acta. Pharmaceutica. Sinica., 2012, 47(4), 512-516.
    • (2012) Yao Xue Xue Bao= Acta. Pharmaceutica. Sinica , vol.47 , Issue.4 , pp. 512-516
    • Liu, X.1    Zhang, W.2    Wei, G.3    Lu, W.4
  • 99
    • 0025733478 scopus 로고
    • Formation, nutritional value, and safety of D-amino acids
    • Friedman, M. Formation, nutritional value, and safety of D-amino acids. Adv. Exp. Med. Biol., 1991, 289, 447-481.
    • (1991) Adv. Exp. Med. Biol , vol.289 , pp. 447-481
    • Friedman, M.1
  • 100
    • 84874558061 scopus 로고    scopus 로고
    • Overcoming oral insulin delivery barriers: Application of cell penetrating peptide and silica-based nanoporous composites
    • He, H.; Ye, J.; Sheng, J.; Wang, J.; Huang, Y.; Chen, G.; Wang, J.; Yang, V.C. Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites. Front. Chem. Sci. Eng., 2013, 7(1), 9-19.
    • (2013) Front. Chem. Sci. Eng , vol.7 , Issue.1 , pp. 9-19
    • He, H.1    Ye, J.2    Sheng, J.3    Wang, J.4    Huang, Y.5    Chen, G.6    Wang, J.7    Yang, V.C.8
  • 101
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • Frankel, A.D.; Pabo, C.O. Cellular uptake of the tat protein from human immunodeficiency virus. Cell, 1988, 55(6), 1189-1193.
    • (1988) Cell , vol.55 , Issue.6 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 102
    • 84860781205 scopus 로고    scopus 로고
    • Identification of a novel skin penetration enhancement peptide by phage display peptide library screening
    • Kumar, S.; Sahdev, P.; Perumal, O.; Tummala, H. Identification of a novel skin penetration enhancement peptide by phage display peptide library screening. Mol. Pharm., 2012, 9(5), 1320-1330.
    • (2012) Mol. Pharm , vol.9 , Issue.5 , pp. 1320-1330
    • Kumar, S.1    Sahdev, P.2    Perumal, O.3    Tummala, H.4


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