One-month subchronic toxicity study of cell-penetrating peptides for insulin nasal delivery in rats

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART A, 2013, Pages 736-743

  Khafagy, El Sayed ^a,b   Kamei, Noriyasu ^a   Nielsen, Ebbe Juel Bech ^a,c   Nishio, Reiji ^d   Takeda Morishita, Mariko ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b Suez Canal University   (Egypt)

^c NOVO NORDISK A S   (Denmark)

^d TORAY INDUSTRIES INC   (Japan)

Author keywords

Cell penetrating peptide; Insulin; Long term administration; Nasal delivery; Penetratin; Toxicity

Indexed keywords

INSULIN; PENETRATIN; TAURODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; IMMUNOGENICITY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NOSE CAVITY; NOSE MUCOSA; NOSE MUCUS; PLASMA CONCENTRATION-TIME CURVE; RAT; RISK FACTOR; TIME TO MAXIMUM PLASMA CONCENTRATION;

CELL-PENETRATING PEPTIDE; INSULIN; LONG-TERM ADMINISTRATION; NASAL DELIVERY; PENETRATIN; TOXICITY;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL AVAILABILITY; CARRIER PROTEINS; CELL-PENETRATING PEPTIDES; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; NASAL MUCOSA; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TOXICITY TESTS, SUBCHRONIC;

EID: 84888357305     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.09.014     Document Type: Article

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