Effects of sperminated polymers on the pulmonary absorption of insulin

Journal of Controlled Release

Volumn 125, Issue 3, 2008, Pages 246-251

  Seki, Toshinobu ^a   Fukushi, Nanako ^a   Chono, Sumio ^a   Morimoto, Kazuhiro ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Gelatin; Insulin; Pullulan; Pulmonary absorption; Sperminated polymers

Indexed keywords

CELLS; DEXTRAN; INSULIN; MONOLAYERS; ZETA POTENTIAL;

GELATIN; LUMINAL SURFACE; PULLULAN; PULMONARY ABSORPTION; SPERMINATED POLYMERS;

CONJUGATED POLYMERS;

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GELATIN; INSULIN; POLYMER; PULLULAN;

ABSORPTION; ANIMAL EXPERIMENT; ARTICLE; ERYTHROCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MUCOSA; NONHUMAN; PRIORITY JOURNAL; RAT; ZETA POTENTIAL;

ABSORPTION; ADMINISTRATION, INHALATION; ANIMALS; AREA UNDER CURVE; BLOOD GLUCOSE; CELL LINE, TUMOR; FASTING; GELATIN; HUMANS; INSULIN; LUNG; MALE; MOLECULAR WEIGHT; POLYMERS; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SPERMINE;

EID: 38349086145     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.10.017     Document Type: Article

References (24)

1. Gonda I. Systemic delivery of drugs to humans via inhalation. J. Aerosol Med. 19 (2006) 47-53
2. Wearley L.L. Recent progress in protein and peptide delivery by noninvasive routes. Crit. Rev. Ther. Drug Carrier Syst. 8 (1991) 331-394
3. Sakagami M., and Byron P.R. Respirable microsheres for inhalation: the potential of manipulating pulmonary disposition for improved therapeutic efficacy. Clin. Pharmacokinet. 44 (2005) 263-277
4. Davis S.S., and Illum L. Absorption enhancers for nasal drug delivery. Clin. Pharmacokinet. 42 (2003) 1107-1128
5. Thanou M., Verhoef J.C., and Junginger H.E. Oral drug absorption enhancement by chitosan and its derivatives. Adv. Drug Deliv. Rev. 5 (2001) 117-126
6. Marttin E., Verhoef J.C., Romeijin S.G., and Merkus F.W.H.M. Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity. Pharm. Res. 12 (1995) 1151-1157
7. Merkus F.W.H.M., Schiepper N.G.M., Hermens W.A.J.J., Romeijin V.S.G., and Verhoef J.C. Absorption enhancers in nasal drug delivery: efficacy and safety. J. Control. Release 24 (1993) 201-208
8. Natsume H., Iwata S., Ohtake K., Miyamoto M., Yamaguchi M., Hosoya K., Kobayashi D., Sugibayashi K., and Morimoto Y. Screening of cationic compounds as an absorption enhancer for nasal drug delivery. Int. J. Pharm. 185 (1999) 1-12
9. Wang J., Sakai S., Deguchi Y., Bi D., Tabata Y., and Morimoto K. Aminated gelatin as a nasal absorption enhancer for peptide drugs: evolution of absorption enhancing effect and nasal mucosa perturbation in rats. J. Pharm. Pharmacol. 54 (2002) 181-188
10. Seki T., Kanbayashi H., Chono S., Tabata Y., and Morimoto K. Effects of a sperminated gelatin on the nasal absorption of insulin. Int. J. Pharm. 338 (2007) 213-218
11. Kanatani I., Ikai T., Okazaki A., Jo J., Yamamoto M., Imamura M., Kanematsu A., Yamamoto S., Ito N., Ogawa O., and Tabata Y. Effect of transfer by pullulan-spermine occurs through both clathrin- and raft/caveolae-dependent mechanisms. J. Control. Rlease. 116 (2006) 75-82
12. Seki T., Kanbayashi H., Nagao T., Chono S., Tomita M., Hayashi M., Tabata Y., and Morimoto K. Effect of aminated gelatin on the nasal absorption of insulin in rats. Biol. Pharm. Bull. 28 (2005) 510-514
13. Seki T., Kanbayashi H., Nagao T., Chono S., Tabata Y., and Morimoto K. Effect of cationized gelatins on the paracellular transport of drugs through Caco-2 cell monolayers. J. Pharm. Sci. 95 (2006) 1393-1401
14. Miyamoto M., Natsume H., Iwata S., Ohtake K., Yamaguchi M., Kobayashi D., Sugibayashi K., Yamashita M., and Morimoto Y. Improved nasal absorption of drugs using poly-l-arginine: effects of concentration and molecular weight of poly-l-arginine on the nasal absorption of fuorescein isothiocyanate-dextran in rats. Eur. J. Pharm. Biopharm. 52 (2001) 21-30
15. Florea B.I., Cassara M.L., Junginger H.E., and Borchard G. Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. J. Control. Release 87 (2003) 131-138
16. Nagendry V.C., Patrick H., Mitch K., and Maureen D.D. Comparison of human tracheal/bronchial epithelial cell culture and bovine nasal respiratory explants for nasal drug transport studies. J. Pharm. Sci. 94 (2005) 1976-1985
17. Williams L., and Domen R.E. Zeta potential and vancomycin-red blood cell interactions. Arch. Pathol. Lab. Med. 114 (1990) 1262-1263
18. Mellgren R.L. Interaction of human erythrocyte multicatalytic proteinase with polycations. Biochem. Biophys. Acta. 1040 (1990) 28-34
19. Schipper N.G.M., Olsson S., Hoogstraate J.A., deBoer A.G., Vårum K.M., and Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm. Res. 14 (1997) 923-929
20. Muranishi S. Absorption enhancers. Crit. Rev. Ther. Drug Carrier Syst. 7 (1990) 1-33
21. Yang T., Hussain A., Bai S., Khalil I.A., Harashima H., and Ahsan F. Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin. J. Control. Release 115 (2006) 289-297
22. Watson C.J., Rowland M., and Warhurst G. Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers. Am. J. Physiol. Cell Physiol. 281 (2001) C388-C397
23. Karczewski J., and Groot J. Molecular physiology and pathophysiology of tight junctions III. Tight junction regulation by intracellular messengers: differences in response within and between epithelia. Am. J. Physiol. Gastrointest. Physiol. 279 (2000) G660-G665
24. Ohtake K., Maeno T., Ueda H., Natsume H., and Morimoto Y. Poly-L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro. Pharm. Res. 20 (2003) 153-160