How PEGylation enhances the stability and potency of insulin: A molecular dynamics simulation

Biochemistry

Volumn 50, Issue 13, 2011, Pages 2585-2593

  Yang, Cheng ^a   Lu, Diannan ^a   Liu, Zheng ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEALING PROCEDURES; CONJUGATED PROTEINS; HYDROPHOBIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR INSIGHTS; MOLECULAR LEVELS; OPTIMAL CHAINS; PEGYLATED PROTEINS; PEGYLATION; PROTEIN DRUGS; PROTEIN PHARMACEUTICALS; PROTEIN SURFACE; ROOT MEAN SQUARES; SECONDARY STRUCTURES; SIDE EFFECT; SIMULATION RESULT; SOLVENT ACCESSIBLE SURFACE AREAS; STRUCTURAL STABILITIES; UNDERLYING MECHANISM; WATER MOLECULE;

CHAIN LENGTH; CONJUGATED POLYMERS; DRUG PRODUCTS; HYDROGEN BONDS; HYDROPHOBICITY; INSULIN; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; SIMULATED ANNEALING; STABILITY;

PROTEINS;

HYDROGEN; INSULIN; MACROGOL; PROTEIN; SOLVENT; WATER;

ARTICLE; ATOM; CONJUGATION; CONTROLLED STUDY; DRUG POTENCY; DRUG STABILITY; GLOMERULUS FILTRATION; HYDROGEN BOND; HYDROPHOBICITY; IMMUNOGENICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; SURFACE PROPERTY;

HALF-LIFE; HOT TEMPERATURE; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPOGLYCEMIC AGENTS; INSULIN; MOLECULAR DYNAMICS SIMULATION; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SURFACE PROPERTIES;

EID: 79953186583     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101926u     Document Type: Article

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