α/βTCRs differ in the degree of their specificity for the positively selecting MHC/peptide ligand

Journal of Immunology

Volumn 166, Issue 4, 2001, Pages 2251-2259

  Kraj, P ^a   Pacholczyk, R ^a   Ignatowicz, L ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOCHROME C DERIVED PEPTIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; PEPTIDE AB; PEPTIDE E ALPHA; PEPTIDE EP; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; STRAIN DIFFERENCE; T LYMPHOCYTE SUBPOPULATION; THYMUS; TRANSGENIC MOUSE;

EID: 0035865335     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.4.2251     Document Type: Article

References (72)

1. How many thymocytes audition for selection?
2. The MHC reactivity of the T cell repertoire prior to positive and negative selection
3. Positive selection of thymocytes
4. Peptides in positive selection: A delicate balance
5. T cell receptor antagonist peptides induce positive selection
6. Evidence for a differential avidity model of T cell selection in the thymus
7. + thymocytes
8. T cell tolerance by clonal elimination in the thymus
9. T-cell apoptosis detected in situ during positive and negative selection in the thymus
10. + cells
11. + T cell selection in mice lacking invariant chain expression
12. MHC class II expression in double mutant mice lacking invariant chain and DM functions
13. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules
14. Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms
15. + T cells in the thymus
16. Permissive recognition during positive selection
17. H2-M mutant mice are deficient in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
18. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
19. The repertoire of T cells shaped by a single MHC/peptide ligand
20. + thymocytes selection by a single MHC class II/peptide ligand affected by its expression level in the thymus
21. + T cells in H-2Ma0/0 mice
22. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide
23. + T cells
24. Positive and negative selection of an antigen receptor on T cells in transgenic mice
25. lo thymocytes in vivo
26. + thymocytes in suspension culture by extrathymic antigen-presenting cells
27. Regulation of T cell production in T cell receptor transgenic mice
28. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
29. Weak positive selection of transgenic T cell receptor-bearing thymocytes: Importance of major histocompatibility complex class II, T cell receptor and CD4 surface molecule densities
30. Organ-specific disease provoked by systemic autoimmunity
31. TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand
32. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice
33. Cassette vectors directing expression of T cell receptor genes in transgenic mice
34. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
35. + single positive cells with a class II major histocompatibility complex-restricted receptor
36. k peptide combination
37. Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage
38. Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death
39. + T cells, a single class II MHC/peptide complex positively selects TCRs with various antigen specificities
40. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas: Lack of independent antigen and H-2 recognition
41. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
42. Evidence for the overexpression of the VH4-34(VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire
43. Determination of amino acids on agretopes of pigeon cytochrome c-related peptides specifically bound to 1-A allelic products
44. An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stability
45. Requirement for diverse, low-abundance peptides in positive selection of T cells
46. bm12-reactive T cells
47. A novel MHC class II epitope expressed in thymic medulla but not on cortex
48. b complex by isolated thymic stromal cells
49. Mice lacking the MHC class II-associated invariant chain
50. Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain
51. The influence of invariant chain on the positive selection of single T cell receptor specificities
52. Antigen presentation and T cell development in H2-M-deficient mice
53. Mice lacking MHC class II molecules
54. Evidence for a single-niche model of positive selection
55. In vitro construction of graded thymus chimeras
56. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
57. Inefficient positive selection of T cells directed by haematopoietic cells
58. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
59. Invariant chain can bind MHC class II at a site other than the peptide binding groove
60. Identification of a naturally occurring ligand for thymic positive selection
61. Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes
62. Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide
63. + T cells in lymphopenic hosts
64. A differential-avidity model for T-cell selection
65. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
66. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
67. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
68. +, double-positive stage
69. Molecular requirements for lineage commitment in the thymus: Antibody-mediated receptor engagements reveal a central role for lck in lineage decisions
70. Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures
71. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
72. The crystal structure of a T cell receptor in complex with peptide and MHC class II