메뉴 건너뛰기




Volumn 7, Issue 1, 2014, Pages

Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice

Author keywords

Autophagy; Brain; IL 1 ; Inflammation; Lipopolysaccharide; Mouse

Indexed keywords

BECLIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROTEIN P62; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; BIOLOGICAL MARKER; CYTOKINE; TARGET OF RAPAMYCIN KINASE;

EID: 84907057534     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/s13041-014-0056-z     Document Type: Article
Times cited : (54)

References (82)
  • 1
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • 22500797
    • mTOR signaling in growth control and disease. M Laplante, DM Sabatini, Cell 2012 149 274 293 10.1016/j.cell.2012.03.017 22500797
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 2
    • 84875423993 scopus 로고    scopus 로고
    • Amino acid signalling upstream of mTOR
    • 23361334
    • Amino acid signalling upstream of mTOR. JL Jewell, RC Russell, KL Guan, Nat Rev Mol Cell Biol 2013 14 133 139 10.1038/nrm3522 23361334
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 133-139
    • Jewell, J.L.1    Russell, R.C.2    Guan, K.L.3
  • 3
    • 33645738458 scopus 로고    scopus 로고
    • Complexity of the TOR signaling network
    • 16516475
    • Complexity of the TOR signaling network. K Inoki, KL Guan, Trends Cell Biol 2006 16 206 212 10.1016/j.tcb.2006.02.002 16516475
    • (2006) Trends Cell Biol , vol.16 , pp. 206-212
    • Inoki, K.1    Guan, K.L.2
  • 6
    • 0038124345 scopus 로고    scopus 로고
    • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling
    • 12858558
    • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. RS Williams, P Rosenberg, Cold Spring Harb Symp Quant Biol 2002 67 339 344 10.1101/sqb.2002.67.339 12858558
    • (2002) Cold Spring Harb Symp Quant Biol , vol.67 , pp. 339-344
    • Williams, R.S.1    Rosenberg, P.2
  • 8
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    • 18570871
    • JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Y Wei, S Pattingre, S Sinha, M Bassik, B Levine, Mol Cell 2008 30 678 688 10.1016/j.molcel.2008.06.001 18570871
    • (2008) Mol Cell , vol.30 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 11
    • 84884634690 scopus 로고    scopus 로고
    • Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: Autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
    • 24059496
    • Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers. S Sarkar, Biochem Soc Trans 2013 41 1103 1130 10.1042/BST20130134 24059496
    • (2013) Biochem Soc Trans , vol.41 , pp. 1103-1130
    • Sarkar, S.1
  • 12
    • 84873546725 scopus 로고    scopus 로고
    • Life in the balance - A mechanistic view of the crosstalk between autophagy and apoptosis
    • 23377657
    • Life in the balance-a mechanistic view of the crosstalk between autophagy and apoptosis. AD Rubinstein, A Kimchi, J Cell Sci 2012 125 5259 5268 10.1242/jcs.115865 23377657
    • (2012) J Cell Sci , vol.125 , pp. 5259-5268
    • Rubinstein, A.D.1    Kimchi, A.2
  • 14
    • 84857039937 scopus 로고    scopus 로고
    • Autophagy as an innate immunity paradigm: Expanding the scope and repertoire of pattern recognition receptors
    • 22118953
    • Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. V Deretic, Curr Opin Immunol 2012 24 21 31 10.1016/j.coi.2011.10.006 22118953
    • (2012) Curr Opin Immunol , vol.24 , pp. 21-31
    • Deretic, V.1
  • 15
    • 84882712453 scopus 로고    scopus 로고
    • Autophagy and cellular immune responses
    • 23973220
    • Autophagy and cellular immune responses. Y Ma, L Galluzzi, L Zitvogel, G Kroemer, Immunity 2013 39 211 227 10.1016/j.immuni.2013.07.017 23973220
    • (2013) Immunity , vol.39 , pp. 211-227
    • Ma, Y.1    Galluzzi, L.2    Zitvogel, L.3    Kroemer, G.4
  • 16
    • 84907061966 scopus 로고    scopus 로고
    • Role of Autophagy in the Control of Body Metabolism
    • Role of Autophagy in the Control of Body Metabolism. W Quan, MS Lee, Endocrinol Metab (Seoul) 2013 28 6 11 10.3803/EnM.2013.28.1.6
    • (2013) Endocrinol Metab (Seoul) , vol.28 , pp. 6-11
    • Quan, W.1    Lee, M.S.2
  • 20
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. WTCC Consortium, Nature 2007 447 661 678 10.1038/nature05911
    • (2007) Nature , vol.447 , pp. 661-678
    • Consortium, W.1
  • 26
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
    • 22286270
    • Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. CS Shi, K Shenderov, NN Huang, J Kabat, M Abu-Asab, KA Fitzgerald, A Sher, JH Kehrl, Nat Immunol 2012 13 255 263 10.1038/ni.2215 22286270
    • (2012) Nat Immunol , vol.13 , pp. 255-263
    • Shi, C.S.1    Shenderov, K.2    Huang, N.N.3    Kabat, J.4    Abu-Asab, M.5    Fitzgerald, K.A.6    Sher, A.7    Kehrl, J.H.8
  • 27
    • 84876439466 scopus 로고    scopus 로고
    • Negative regulation of NLRP3 inflammasome signaling
    • 23519777
    • Negative regulation of NLRP3 inflammasome signaling. S Chen, B Sun, Protein Cell 2013 4 251 258 10.1007/s13238-013-2128-8 23519777
    • (2013) Protein Cell , vol.4 , pp. 251-258
    • Chen, S.1    Sun, B.2
  • 28
    • 84900420410 scopus 로고    scopus 로고
    • Crosstalk between autophagy and inflammasomes
    • 24213677
    • Crosstalk between autophagy and inflammasomes. JM Yuk, EK Jo, Mol Cells 2013 36 393 399 10.1007/s10059-013-0298-0 24213677
    • (2013) Mol Cells , vol.36 , pp. 393-399
    • Yuk, J.M.1    Jo, E.K.2
  • 29
    • 84890364356 scopus 로고    scopus 로고
    • Inflammasome activation by altered proteostasis
    • 24178293
    • Inflammasome activation by altered proteostasis. JN Shin, EA Fattah, A Bhattacharya, S Ko, NT Eissa, J Biol Chem 2013 288 35886 35895 10.1074/jbc.M113.514919 24178293
    • (2013) J Biol Chem , vol.288 , pp. 35886-35895
    • Shin, J.N.1    Fattah, E.A.2    Bhattacharya, A.3    Ko, S.4    Eissa, N.T.5
  • 31
    • 84879604162 scopus 로고    scopus 로고
    • NF-kappaB-mediated induction of autophagy in cardiac ischemia/reperfusion injury
    • 23727575
    • NF-kappaB-mediated induction of autophagy in cardiac ischemia/reperfusion injury. M Zeng, X Wei, Z Wu, W Li, B Li, Y Zhen, J Chen, P Wang, Y Fei, Biochem Biophys Res Commun 2013 436 180 185 10.1016/j.bbrc.2013.05.070 23727575
    • (2013) Biochem Biophys Res Commun , vol.436 , pp. 180-185
    • Zeng, M.1    Wei, X.2    Wu, Z.3    Li, W.4    Li, B.5    Zhen, Y.6    Chen, J.7    Wang, P.8    Fei, Y.9
  • 33
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • 15607973
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. MG Gutierrez, SS Master, SB Singh, GA Taylor, MI Colombo, V Deretic, Cell 2004 119 753 766 10.1016/j.cell.2004.11.038 15607973
    • (2004) Cell , vol.119 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 34
    • 34548700401 scopus 로고    scopus 로고
    • T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis
    • 17892853
    • T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. J Harris, SA De Haro, SS Master, J Keane, EA Roberts, M Delgado, V Deretic, Immunity 2007 27 505 517 10.1016/j.immuni.2007.07.022 17892853
    • (2007) Immunity , vol.27 , pp. 505-517
    • Harris, J.1    De Haro, S.A.2    Master, S.S.3    Keane, J.4    Roberts, E.A.5    Delgado, M.6    Deretic, V.7
  • 35
    • 84885998575 scopus 로고    scopus 로고
    • Intestinal Epithelium and Autophagy: Partners in Gut Homeostasis
    • 24137160
    • Intestinal Epithelium and Autophagy: Partners in Gut Homeostasis. S Randall-Demllo, M Chieppa, R Eri, Front Immunol 2013 4 301 10.3389/fimmu.2013.00301 24137160
    • (2013) Front Immunol , vol.4 , pp. 301
    • Randall-Demllo, S.1    Chieppa, M.2    Eri, R.3
  • 37
    • 84860491083 scopus 로고    scopus 로고
    • Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation
    • 22558139
    • Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation. L Pan, Y Li, L Jia, Y Qin, G Qi, J Cheng, Y Qi, H Li, J Du, PLoS One 2012 7 35315 10.1371/journal.pone.0035315 22558139
    • (2012) PLoS One , vol.7 , pp. 535315
    • Pan, L.1    Li, Y.2    Jia, L.3    Qin, Y.4    Qi, G.5    Cheng, J.6    Qi, Y.7    Li, H.8    Du, J.9
  • 38
    • 84896957356 scopus 로고    scopus 로고
    • The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections
    • 24434788
    • The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections. RD Junkins, C McCormick, TJ Lin, Autophagy 2014 10 538 547 10.4161/auto.27750 24434788
    • (2014) Autophagy , vol.10 , pp. 538-547
    • Junkins, R.D.1    McCormick, C.2    Lin, T.J.3
  • 39
    • 84893714992 scopus 로고    scopus 로고
    • Autophagy in aging and neurodegenerative diseases: Implications for pathogenesis and therapy
    • 24360503
    • Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy. CC Tan, JT Yu, MS Tan, T Jiang, XC Zhu, L Tan, Neurobiol Aging 2014 35 941 957 10.1016/j.neurobiolaging.2013.11.019 24360503
    • (2014) Neurobiol Aging , vol.35 , pp. 941-957
    • Tan, C.C.1    Yu, J.T.2    Tan, M.S.3    Jiang, T.4    Zhu, X.C.5    Tan, L.6
  • 40
    • 67349280877 scopus 로고    scopus 로고
    • Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice
    • 18987969
    • Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice. T Nishioku, S Dohgu, F Takata, T Eto, N Ishikawa, KB Kodama, S Nakagawa, A Yamauchi, Y Kataoka, Cell Mol Neurobiol 2009 29 309 316 10.1007/s10571-008-9322-x 18987969
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 309-316
    • Nishioku, T.1    Dohgu, S.2    Takata, F.3    Eto, T.4    Ishikawa, N.5    Kodama, K.B.6    Nakagawa, S.7    Yamauchi, A.8    Kataoka, Y.9
  • 41
    • 84882747218 scopus 로고    scopus 로고
    • Various roles of astrocytes during recovery from repeated exposure to different doses of lipopolysaccharide
    • 23896049
    • Various roles of astrocytes during recovery from repeated exposure to different doses of lipopolysaccharide. Y Bian, X Zhao, M Li, S Zeng, B Zhao, Behav Brain Res 2013 253 253 261 10.1016/j.bbr.2013.07.028 23896049
    • (2013) Behav Brain Res , vol.253 , pp. 253-261
    • Bian, Y.1    Zhao, X.2    Li, M.3    Zeng, S.4    Zhao, B.5
  • 42
    • 52049098912 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP technology
    • 18771691
    • Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP technology. SC Datta, MR Opp, J Neurosci Methods 2008 175 119 124 10.1016/j.jneumeth.2008.08.007 18771691
    • (2008) J Neurosci Methods , vol.175 , pp. 119-124
    • Datta, S.C.1    Opp, M.R.2
  • 43
    • 25144435958 scopus 로고    scopus 로고
    • Systemic inflammation induces apoptosis with variable vulnerability of different brain regions
    • 16122904
    • Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. A Semmler, T Okulla, M Sastre, L Dumitrescu-Ozimek, MT Heneka, J Chem Neuroanat 2005 30 144 157 10.1016/j.jchemneu.2005.07.003 16122904
    • (2005) J Chem Neuroanat , vol.30 , pp. 144-157
    • Semmler, A.1    Okulla, T.2    Sastre, M.3    Dumitrescu-Ozimek, L.4    Heneka, M.T.5
  • 44
    • 0028314343 scopus 로고
    • Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide
    • 8294551
    • Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide. N Quan, SK Sundar, JM Weiss, J Neuroimmunol 1994 49 125 134 10.1016/0165-5728(94)90188-0 8294551
    • (1994) J Neuroimmunol , vol.49 , pp. 125-134
    • Quan, N.1    Sundar, S.K.2    Weiss, J.M.3
  • 46
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • 21311563
    • The Beclin 1 network regulates autophagy and apoptosis. R Kang, HJ Zeh, MT Lotze, D Tang, Cell Death Differ 2011 18 571 580 10.1038/cdd.2010.191 21311563
    • (2011) Cell Death Differ , vol.18 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 48
    • 78650239404 scopus 로고    scopus 로고
    • Functions and regulation of the 70 kDa ribosomal S6 kinases
    • 20932932
    • Functions and regulation of the 70 kDa ribosomal S6 kinases. TR Fenton, IT Gout, Int J Biochem Cell Biol 2011 43 47 59 10.1016/j.biocel.2010.09.018 20932932
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 47-59
    • Fenton, T.R.1    Gout, I.T.2
  • 49
    • 79951529849 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: Hitting the bull's-eye for neurological disorders
    • Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders. ZZ Chong, YC Shang, L Zhang, S Wang, K Maiese, Oxidative Med Cell Longev 2010 3 374 391 10.4161/oxim.3.6.14787
    • (2010) Oxidative Med Cell Longev , vol.3 , pp. 374-391
    • Chong, Z.Z.1    Shang, Y.C.2    Zhang, L.3    Wang, S.4    Maiese, K.5
  • 50
    • 84889985155 scopus 로고    scopus 로고
    • Involvement of interleukin-1beta in the autophagic process of microglia: Relevance to Alzheimer's disease
    • 24330807
    • Involvement of interleukin-1beta in the autophagic process of microglia: relevance to Alzheimer's disease. A Francois, F Terro, T Janet, AR Bilan, M Paccalin, G Page, J Neuroinflammation 2013 10 151 10.1186/1742-2094-10-151 24330807
    • (2013) J Neuroinflammation , vol.10 , pp. 151
    • Francois, A.1    Terro, F.2    Janet, T.3    Bilan, A.R.4    Paccalin, M.5    Page, G.6
  • 51
    • 77956871080 scopus 로고    scopus 로고
    • Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus
    • 20696148
    • Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus. GA Czapski, B Gajkowska, JB Strosznajder, Brain Res 2010 1356 85 94 10.1016/j.brainres.2010.07.096 20696148
    • (2010) Brain Res , vol.1356 , pp. 85-94
    • Czapski, G.A.1    Gajkowska, B.2    Strosznajder, J.B.3
  • 52
    • 77955427864 scopus 로고    scopus 로고
    • Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus
    • 19908141
    • Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. DW Chung, KY Yoo, IK Hwang, DW Kim, JY Chung, CH Lee, JH Choi, SY Choi, HY Youn, IS Lee, MH Won, Cell Mol Neurobiol 2010 30 531 541 10.1007/s10571-009-9477-0 19908141
    • (2010) Cell Mol Neurobiol , vol.30 , pp. 531-541
    • Chung, D.W.1    Yoo, K.Y.2    Hwang, I.K.3    Kim, D.W.4    Chung, J.Y.5    Lee, C.H.6    Choi, J.H.7    Choi, S.Y.8    Youn, H.Y.9    Lee, I.S.10    Won, M.H.11
  • 53
    • 53349129897 scopus 로고    scopus 로고
    • Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation
    • 18759972
    • Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. JW Lee, YK Lee, DY Yuk, DY Choi, SB Ban, KW Oh, JT Hong, J Neuroinflammation 2008 5 37 10.1186/1742-2094-5-37 18759972
    • (2008) J Neuroinflammation , vol.5 , pp. 37
    • Lee, J.W.1    Lee, Y.K.2    Yuk, D.Y.3    Choi, D.Y.4    Ban, S.B.5    Oh, K.W.6    Hong, J.T.7
  • 54
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    • 17203472
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. L Qin, X Wu, ML Block, Y Liu, GR Breese, JS Hong, DJ Knapp, FT Crews, Glia 2007 55 453 462 10.1002/glia.20467 17203472
    • (2007) Glia , vol.55 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3    Liu, Y.4    Breese, G.R.5    Hong, J.S.6    Knapp, D.J.7    Crews, F.T.8
  • 56
    • 84861179515 scopus 로고    scopus 로고
    • Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation
    • 22607609
    • Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation. K Fan, X Wu, B Fan, N Li, Y Lin, Y Yao, J Ma, J Neuroinflammation 2012 9 96 10.1186/1742-2094-9-96 22607609
    • (2012) J Neuroinflammation , vol.9 , pp. 96
    • Fan, K.1    Wu, X.2    Fan, B.3    Li, N.4    Lin, Y.5    Yao, Y.6    Ma, J.7
  • 57
    • 79955971316 scopus 로고    scopus 로고
    • Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1beta and IL-6
    • 21586125
    • Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1beta and IL-6. CL Murray, DT Skelly, C Cunningham, J Neuroinflammation 2011 8 50 10.1186/1742-2094-8-50 21586125
    • (2011) J Neuroinflammation , vol.8 , pp. 50
    • Murray, C.L.1    Skelly, D.T.2    Cunningham, C.3
  • 58
    • 67650763412 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide administration induces cytokine mRNA expression in the viscera and brain of fever-refractory mice lacking microsomal prostaglandin e synthase-1
    • 19500218
    • Peripheral lipopolysaccharide administration induces cytokine mRNA expression in the viscera and brain of fever-refractory mice lacking microsomal prostaglandin E synthase-1. C Nilsberth, N Hamzic, M Norell, A Blomqvist, J Neuroendocrinol 2009 21 715 721 10.1111/j.1365-2826.2009.01888.x 19500218
    • (2009) J Neuroendocrinol , vol.21 , pp. 715-721
    • Nilsberth, C.1    Hamzic, N.2    Norell, M.3    Blomqvist, A.4
  • 60
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • 16192374
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. M Kitazawa, S Oddo, TR Yamasaki, KN Green, FM LaFerla, J Neurosci 2005 25 8843 8853 10.1523/JNEUROSCI.2868-05.2005 16192374
    • (2005) J Neurosci , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    Laferla, F.M.5
  • 62
    • 84860285084 scopus 로고    scopus 로고
    • Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Abeta42 levels in the late stages of the Alzheimer's disease
    • 22272616
    • Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Abeta42 levels in the late stages of the Alzheimer's disease. J Couturier, M Paccalin, C Lafay-Chebassier, S Chalon, I Ingrand, J Pinguet, R Pontcharraud, O Guillard, B Fauconneau, G Page, Curr Alzheimer Res 2012 9 344 360 10.2174/156720512800107582 22272616
    • (2012) Curr Alzheimer Res , vol.9 , pp. 344-360
    • Couturier, J.1    Paccalin, M.2    Lafay-Chebassier, C.3    Chalon, S.4    Ingrand, I.5    Pinguet, J.6    Pontcharraud, R.7    Guillard, O.8    Fauconneau, B.9    Page, G.10
  • 63
    • 0034130707 scopus 로고    scopus 로고
    • Cell mediators of inflammation in the Alzheimer disease brain
    • 10850730
    • Cell mediators of inflammation in the Alzheimer disease brain. H Akiyama, T Arai, H Kondo, E Tanno, C Haga, K Ikeda, Alzheimer Dis Assoc Disord 2000 14 Suppl 1 47 S53 10.1097/00002093-200000001-00008 10850730
    • (2000) Alzheimer Dis Assoc Disord , vol.14 , pp. 1947-S53
    • Akiyama, H.1    Arai, T.2    Kondo, H.3    Tanno, E.4    Haga, C.5    Ikeda, K.6
  • 64
    • 0034304390 scopus 로고    scopus 로고
    • The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review
    • 11059790
    • The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. RA Nixon, AM Cataldo, PM Mathews, Neurochem Res 2000 25 1161 1172 10.1023/A:1007675508413 11059790
    • (2000) Neurochem Res , vol.25 , pp. 1161-1172
    • Nixon, R.A.1    Cataldo, A.M.2    Mathews, P.M.3
  • 65
    • 0036198649 scopus 로고    scopus 로고
    • Peripheral LPS administrations up-regulate Fas and FasL on brain microglial cells: A brain protective or pathogenic event?
    • 11958821
    • Peripheral LPS administrations up-regulate Fas and FasL on brain microglial cells: a brain protective or pathogenic event? S Terrazzino, A Bauleo, A Baldan, A Leon, J Neuroimmunol 2002 124 45 53 10.1016/S0165-5728(02)00013-9 11958821
    • (2002) J Neuroimmunol , vol.124 , pp. 45-53
    • Terrazzino, S.1    Bauleo, A.2    Baldan, A.3    Leon, A.4
  • 67
    • 79951910694 scopus 로고    scopus 로고
    • Autophagy in immunity and cell-autonomous defense against intracellular microbes
    • 21349088
    • Autophagy in immunity and cell-autonomous defense against intracellular microbes. V Deretic, Immunol Rev 2011 240 92 104 10.1111/j.1600-065X.2010.00995.x 21349088
    • (2011) Immunol Rev , vol.240 , pp. 92-104
    • Deretic, V.1
  • 69
    • 84865299726 scopus 로고    scopus 로고
    • PAMPs and DAMPs: Signal 0 s that spur autophagy and immunity
    • 22889221
    • PAMPs and DAMPs: signal 0 s that spur autophagy and immunity. D Tang, R Kang, CB Coyne, HJ Zeh, MT Lotze, Immunol Rev 2012 249 158 175 10.1111/j.1600-065X.2012.01146.x 22889221
    • (2012) Immunol Rev , vol.249 , pp. 158-175
    • Tang, D.1    Kang, R.2    Coyne, C.B.3    Zeh, H.J.4    Lotze, M.T.5
  • 70
    • 0033609834 scopus 로고    scopus 로고
    • Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase
    • 10455142
    • Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase. LA Parrott, DJ Templeton, J Biol Chem 1999 274 24731 24736 10.1074/jbc.274.35.24731 10455142
    • (1999) J Biol Chem , vol.274 , pp. 24731-24736
    • Parrott, L.A.1    Templeton, D.J.2
  • 71
    • 0034671578 scopus 로고    scopus 로고
    • TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest
    • 11124802
    • TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. C Petritsch, H Beug, A Balmain, M Oft, Genes Dev 2000 14 3093 3101 10.1101/gad.854200 11124802
    • (2000) Genes Dev , vol.14 , pp. 3093-3101
    • Petritsch, C.1    Beug, H.2    Balmain, A.3    Oft, M.4
  • 72
    • 18444389773 scopus 로고    scopus 로고
    • TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle
    • 15534870
    • TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle. CH Lang, AM Pruznak, RA Frost, J Cell Biochem 2005 94 419 431 10.1002/jcb.20311 15534870
    • (2005) J Cell Biochem , vol.94 , pp. 419-431
    • Lang, C.H.1    Pruznak, A.M.2    Frost, R.A.3
  • 75
    • 84885173202 scopus 로고    scopus 로고
    • Dynamic expressions of Beclin 1 and tyrosine hydroxylase in different areas of 6-hydroxydopamine-induced Parkinsonian rats
    • 23868341
    • Dynamic expressions of Beclin 1 and tyrosine hydroxylase in different areas of 6-hydroxydopamine-induced Parkinsonian rats. S Zhang, ZF Xue, LP Huang, RM Fang, YP He, L Li, YQ Fang, Cell Mol Neurobiol 2013 33 973 981 10.1007/s10571-013-9964-1 23868341
    • (2013) Cell Mol Neurobiol , vol.33 , pp. 973-981
    • Zhang, S.1    Xue, Z.F.2    Huang, L.P.3    Fang, R.M.4    He, Y.P.5    Li, L.6    Fang, Y.Q.7
  • 76
    • 33746311486 scopus 로고    scopus 로고
    • The blood-brain barrier in psychoneuroimmunology
    • 16877115
    • The blood-brain barrier in psychoneuroimmunology. WA Banks, Neurol Clin 2006 24 413 419 10.1016/j.ncl.2006.03.009 16877115
    • (2006) Neurol Clin , vol.24 , pp. 413-419
    • Banks, W.A.1
  • 77
    • 2542466803 scopus 로고    scopus 로고
    • Signaling the brain in systemic inflammation: Role of sensory circumventricular organs
    • 14766367
    • Signaling the brain in systemic inflammation: role of sensory circumventricular organs. J Roth, EM Harre, C Rummel, R Gerstberger, T Hubschle, Front Biosci 2004 9 290 300 10.2741/1241 14766367
    • (2004) Front Biosci , vol.9 , pp. 290-300
    • Roth, J.1    Harre, E.M.2    Rummel, C.3    Gerstberger, R.4    Hubschle, T.5
  • 78
    • 78651412528 scopus 로고    scopus 로고
    • Immune modulation of learning, memory, neural plasticity and neurogenesis
    • 20970492
    • Immune modulation of learning, memory, neural plasticity and neurogenesis. R Yirmiya, I Goshen, Brain Behav Immun 2011 25 181 213 10.1016/j.bbi.2010.10.015 20970492
    • (2011) Brain Behav Immun , vol.25 , pp. 181-213
    • Yirmiya, R.1    Goshen, I.2
  • 79
    • 84878405540 scopus 로고    scopus 로고
    • Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress
    • 23589298
    • Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress. Q Sun, W Gao, P Loughran, R Shapiro, J Fan, TR Billiar, MJ Scott, J Biol Chem 2013 288 15947 15958 10.1074/jbc.M112.426791 23589298
    • (2013) J Biol Chem , vol.288 , pp. 15947-15958
    • Sun, Q.1    Gao, W.2    Loughran, P.3    Shapiro, R.4    Fan, J.5    Billiar, T.R.6    Scott, M.J.7
  • 80
    • 84898006751 scopus 로고    scopus 로고
    • SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity
    • 24374573
    • SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity. S Ohtsuka, Y Ishii, M Matsuyama, S Ano, Y Morishima, T Yanagawa, E Warabi, N Hizawa, Eur J Immunol 2014 44 1084 1092 10.1002/eji.201344091 24374573
    • (2014) Eur J Immunol , vol.44 , pp. 1084-1092
    • Ohtsuka, S.1    Ishii, Y.2    Matsuyama, M.3    Ano, S.4    Morishima, Y.5    Yanagawa, T.6    Warabi, E.7    Hizawa, N.8
  • 81
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • 17580304
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. S Pankiv, TH Clausen, T Lamark, A Brech, JA Bruun, H Outzen, A Overvatn, G Bjorkoy, T Johansen, J Biol Chem 2007 282 24131 24145 10.1074/jbc.M702824200 17580304
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6    Overvatn, A.7    Bjorkoy, G.8    Johansen, T.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.