Dynamic expressions of beclin 1 and tyrosine hydroxylase in different areas of 6-hydroxydopamine-induced parkinsonian rats

Cellular and Molecular Neurobiology

Volumn 33, Issue 7, 2013, Pages 973-981

  Zhang, Sheng ^a   Xue, Zhong Feng ^a   Huang, Li Ping ^a   Fang, Ruo Ming ^a   He, Yu Ping ^a   Li, Ling ^a   Fang, Yong Qi ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Beclin 1; Cortex; Hippocampus; Parkinson's disease; Striatum; Tyrosine hydroxylase

Indexed keywords

BECLIN 1; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; FEMALE; FLOW CYTOMETRY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

PARKINSONIA; RATTUS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BRAIN; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INJECTIONS; ORGAN SPECIFICITY; OXIDOPAMINE; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE;

EID: 84885173202     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-013-9964-1     Document Type: Article

References (33)

1. Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, Savitt JM (2012) Development and characterization of a new Parkinson's disease model resulting from impaired autophagy. J Neurosci 32(46):16503-16509
2. Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J, Mouatt-Prigent A, Ruberg M, Hirsch EC, Agid Y (1997) Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 12:25-31
3. Chung KK, Dawson VL, Dawson TM (2003) New insights into Parkinson's disease. J Neurol 250(Suppl 3):15-24
4. Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305:1292-1295
5. Dagda RK, Zhu J, Kulich SM, Chu CT (2008) Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy 4:770-782
6. Erlich S, Shohami E, Pinkas-Kramarski R (2006) Neurodegeneration induces upregulation of Beclin 1. Autophagy 2:49-51
7. Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F (2007) Ambra1 regulates autophagy and development of the nervous system. Nature 447:1121-1125
8. Fouillet A, Levet C, Virgone A, Robin M, Dourlen P, Rieusset J, Belaidi E, Ovize M, Touret M, Nataf S, Mollereau B (2012) ER stress inhibits neuronal death by promoting autophagy. Autophagy 8(6):915-926
9. Funderburk SF, Wang QJ, Yue Z (2010) The Beclin 1-VPS34 complex at the crossroads of autophagy and beyond. Trends Cell Biol 20:355-362
10. Gee P, Davison AJ (1989) Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditions. Free Radic Biol Med 6:271-284
11. Hamacher-Brady A, Brady NR, Gottlieb RA (2006) Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 281:29776-29787
12. He Y, Mo Z, Xue Z, Fang Y (2013) Establish a flow cytometric method for quantitative detection of Beclin-1 expression. Cytotechnology. doi: 10.1007/s10616-012-9503-9
13. Hong Z, Wang G, Gu J, Pan J, Bai L, Zhang S, Chen SD (2007) Tripchlorolide protects against MPTP-induced neurotoxicity in C57BL/6 mice. Eur J Neurosci 26(6):1500-1508
14. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N (2004) The role of autophagy during the early neonatal starvation period. Nature 432:1032-1036
15. Lehmensiek V, Tan EM, Liebau S, Lenk T, Zettlmeisl H, Schwarz J, Storch A (2006) Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease. Neurochem Int 483:329-340
16. Levitt M, Spector S, Sjoerdsma A, Udenfriend S (1965) Elucidation of the rate limiting step in norepinephrine biosynthesis in the perfused guinea pig heart. J Pharmacol Exp Ther 148:1-8
17. Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z (2011) Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett 489:62-67
18. Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU (2006) Autophagic and tumour suppressor activity of a novel Beclin 1-binding protein UVRAG. Nat Cell Biol 8:688-699
19. Liu K, Shi N, Sun Y, Zhang T, Sun X (2013) Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice. Neurochem Res 38:201-207
20. Lopez Verrilli MA, Pirola CJ, Pascual MM, Dominici FP, Turyn D, Gironacci MM (2009) Angiotensin-(1-7) through AT receptors mediates tyrosine hydroxylase degradation via the ubiquitin proteasome pathway. J Neurochem 109:326-335
21. Marin C, Aguilar E (2011) In vivo 6-OHDA-induced neurodegeneration and nigral autophagic markers expression. Neurochem Int 58(4):521-526
22. Nakashima A, Mori K, Kaneko YS, Hayashi N, Nagatsu T, Ota A (2011) Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme. Biochem Biophys Res Commun 407:343-347
23. Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S (2009) Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 461:654-658
24. Pan T, Kondo S, Le W, Jankovic J (2008a) The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 131:1969-1978
25. Pan T, Kondo S, Zhu W, Xie W, Jankovic J, Le W (2008b) Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement. Neurobiol Dis 32:16-25
26. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic, San Diego
27. Rodríguez S, Uchida K, Nakayama H (2013) Striatal TH-immunopositive fibers recover after an intrastriatal injection of 6-hydroxydopamine in golden hamsters treated with prednisolone: roles of tumor necrosis factor-α and inducible nitric oxide synthase in neurodegeneration. Neurosci Res. doi: 10.1016/j.neures.2013.02.004
28. Scatton B, Simon H, Le Moal M, Bischoff S (1980) Origin of dopaminergic innervation of the rat hippocampal formation. Neurosci Lett 18:125-131
29. Shen YF, Tang Y, Zhang XJ, Huang KX, Le WD (2013) Adaptive changes in autophagy after UPS impairment in Parkinson's disease. Acta Pharmacol Sin 34:667-673
30. Solesio ME, Saez-Atienzar S, Jordán J, Galindo MF (2012) Characterization of mitophagy in the 6-hydroxydopamine Parkinson's disease model. Toxicol Sci 129(2):411-420
31. Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E (2009) Beclin 1 Gene transfer activates autophagy and ameliorates the neurodegenerative pathology in α-synuclein models of Parkinson's and lewy body diseases. J Neurosci 29(43):13578-13588
32. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ (2004) Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304:1500-1502
33. Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100:15077-15082