메뉴 건너뛰기




Volumn 29, Issue 5, 2014, Pages 304-313

The gut-adipose-liver axis in the metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; GASTROINTESTINAL TRACT; HUMAN; INSULIN RESISTANCE; LIVER; METABOLIC SYNDROME X; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSIOLOGY;

EID: 84906896358     PISSN: 15489213     EISSN: 15489221     Source Type: Journal    
DOI: 10.1152/physiol.00014.2014     Document Type: Review
Times cited : (82)

References (136)
  • 2
    • 79952046540 scopus 로고    scopus 로고
    • Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet
    • Adapala VJ, Buhman KK, Ajuwon KM. Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet. J Inflamm 8: 5, 2011
    • (2011) J Inflamm , vol.8 , pp. 5
    • Adapala, V.J.1    Buhman, K.K.2    Ajuwon, K.M.3
  • 10
    • 0018404843 scopus 로고
    • Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model
    • Berg RD, Garlington AW. Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 23: 403-411, 1979
    • (1979) Infect Immun , vol.23 , pp. 403-411
    • Berg, R.D.1    Garlington, A.W.2
  • 12
    • 0346731246 scopus 로고    scopus 로고
    • How we detect microbes and respond to them: The Toll-like receptors and their transducers
    • Beutler B, Hoebe K, Du X, Ulevitch RJ. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J Leukoc Biol 74: 479-485, 2003
    • (2003) J Leukoc Biol , vol.74 , pp. 479-485
    • Beutler, B.1    Hoebe, K.2    Du, X.3    Ulevitch, R.J.4
  • 16
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet- induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet- induced obesity and diabetes in mice. Diabetes 57: 1470-1481, 2008
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 18
    • 34250748977 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/ TCF4(TCF7L2)-dependent pathway
    • Cawthorn WP, Heyd F, Hegyi K, Sethi JK. Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/ TCF4(TCF7L2)-dependent pathway. Cell Death Differentiation 14: 1361-1373, 2007
    • (2007) Cell Death Differentiation , vol.14 , pp. 1361-1373
    • Cawthorn, W.P.1    Heyd, F.2    Hegyi, K.3    Sethi, J.K.4
  • 20
    • 84871305315 scopus 로고    scopus 로고
    • Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation
    • Corbitt N, Kimura S, Isse K, Specht S, Chedwick L, Rosborough BR, Lunz JG, Murase N, Yokota S, Demetris AJ. Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation. Am J Pathol 182: 180-191, 2013
    • (2013) Am J Pathol , vol.182 , pp. 180-191
    • Corbitt, N.1    Kimura, S.2    Isse, K.3    Specht, S.4    Chedwick, L.5    Rosborough, B.R.6    Lunz, J.G.7    Murase, N.8    Yokota, S.9    Demetris, A.J.10
  • 24
    • 0036121583 scopus 로고    scopus 로고
    • Bacterial translocation or lymphatic drainage of toxic products from the gut: What is important in human beings
    • Deitch EA. Bacterial translocation or lymphatic drainage of toxic products from the gut: What is important in human beings? Surgery 131: 241-244, 2002
    • (2002) Surgery , vol.131 , pp. 241-244
    • Deitch, E.A.1
  • 25
    • 0035003391 scopus 로고    scopus 로고
    • Role of the gut lymphatic system in multiple organ failure
    • Deitch EA. Role of the gut lymphatic system in multiple organ failure. Curr Opin Crit Care 7: 92-98, 2001
    • (2001) Curr Opin Crit Care , vol.7 , pp. 92-98
    • Deitch, E.A.1
  • 26
    • 0031831765 scopus 로고    scopus 로고
    • Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum
    • DiGirolamo M, Fine JB, Tagra K, Rossmanith R. Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum. Am J Physiol Regul Integr Comp Physiol 274: R1460-R1467, 1998
    • (1998) Am J Physiol Regul Integr Comp Physiol , vol.274
    • Digirolamo, M.1    Fine, J.B.2    Tagra, K.3    Rossmanith, R.4
  • 27
    • 77957880664 scopus 로고    scopus 로고
    • High-fat diet: Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse
    • Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLos One 5: e12191, 2010
    • (2010) PLos One , vol.5
    • Ding, S.1    Chi, M.M.2    Scull, B.P.3    Rigby, R.4    Schwerbrock, N.M.5    Magness, S.6    Jobin, C.7    Lund, P.K.8
  • 28
    • 77955271961 scopus 로고    scopus 로고
    • Lymphatic lipid transport: Sewer or subway?
    • Dixon JB. Lymphatic lipid transport: sewer or subway? Trends Endocrinol Metab 21: 480-487, 2010
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 480-487
    • Dixon, J.B.1
  • 29
    • 0035102168 scopus 로고    scopus 로고
    • Effect of ischemia on intestinal permeability of lipopolysaccharides
    • Drewe J, Beglinger C, Fricker G. Effect of ischemia on intestinal permeability of lipopolysaccharides. Eur J Clin Invest 31: 138-144, 2001
    • (2001) Eur J Clin Invest , vol.31 , pp. 138-144
    • Drewe, J.1    Beglinger, C.2    Fricker, G.3
  • 39
    • 67649216750 scopus 로고    scopus 로고
    • Intestinal barrier function: Molecular regulation and disease pathogenesis
    • quiz 21-22, 2009
    • Groschwitz KR, Hogan SP. Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol 124: 3-20; quiz 21-22, 2009
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 3-20
    • Groschwitz, K.R.1    Hogan, S.P.2
  • 40
    • 84887336799 scopus 로고    scopus 로고
    • Induction of cytosolic phospholipase a2alpha is required for adipose neutrophil infiltration and hepatic insulin resistance early in the course of high-fat feeding
    • Hadad N, Burgazliev O, Elgazar-Carmon V, Solomonov Y, Wueest S, Item F, Konrad D, Rudich A, Levy R. Induction of cytosolic phospholipase a2alpha is required for adipose neutrophil infiltration and hepatic insulin resistance early in the course of high-fat feeding. Diabetes 62: 3053-3063, 2013
    • (2013) Diabetes , vol.62 , pp. 3053-3063
    • Hadad, N.1    Burgazliev, O.2    Elgazar-Carmon, V.3    Solomonov, Y.4    Wueest, S.5    Item, F.6    Konrad, D.7    Rudich, A.8    Levy, R.9
  • 41
    • 42649141962 scopus 로고    scopus 로고
    • Location, location, location
    • Harris RB, Leibel RL. Location, location, location. Cell Metab 7: 359-361, 2008
    • (2008) Cell Metab , vol.7 , pp. 359-361
    • Harris, R.B.1    Leibel, R.L.2
  • 43
    • 41849094743 scopus 로고    scopus 로고
    • Studies of regional adipose transplantation reveal a unique and beneficial interaction between subcutaneous adipose tissue and the intra-abdominal compartment
    • Hocking SL, Chisholm DJ, James DE. Studies of regional adipose transplantation reveal a unique and beneficial interaction between subcutaneous adipose tissue and the intra-abdominal compartment. Diabetologia 51: 900-902, 2008
    • (2008) Diabetologia , vol.51 , pp. 900-902
    • Hocking, S.L.1    Chisholm, D.J.2    James, D.E.3
  • 44
    • 70349525063 scopus 로고    scopus 로고
    • Prox-1 and FOXC2 gene expression in adipose tissue: A potential contributory role of the lymphatic system to familial combined hyperlipidaemia
    • Horra A, Salazar J, Ferre R, Vallve JC, Guardiola M, Rosales R, Masana L, Ribalta J. Prox-1 and FOXC2 gene expression in adipose tissue: a potential contributory role of the lymphatic system to familial combined hyperlipidaemia. Atherosclerosis 206: 343-345, 2009
    • (2009) Atherosclerosis , vol.206 , pp. 343-345
    • Horra, A.1    Salazar, J.2    Ferre, R.3    Vallve, J.C.4    Guardiola, M.5    Rosales, R.6    Masana, L.7    Ribalta, J.8
  • 46
    • 67650242164 scopus 로고    scopus 로고
    • Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factor-alpha, and inflammation
    • Isakson P, Hammarstedt A, Gustafson B, Smith U. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes 58: 1550-1557, 2009
    • (2009) Diabetes , vol.58 , pp. 1550-1557
    • Isakson, P.1    Hammarstedt, A.2    Gustafson, B.3    Smith, U.4
  • 47
    • 84868159135 scopus 로고    scopus 로고
    • Visceral fat and metabolic inflammation: The portal theory revisited
    • Item F, Konrad D. Visceral fat and metabolic inflammation: the portal theory revisited. Obes Rev 13, Suppl 2: 30-39, 2012
    • (2012) Obes Rev , vol.13 , Issue.SUPPL. 2 , pp. 30-39
    • Item, F.1    Konrad, D.2
  • 49
    • 84863808516 scopus 로고    scopus 로고
    • Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4
    • Ji Y, Sun S, Xia S, Yang L, Li X, Qi L. Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4. J Biol Chem 287: 24378-24386, 2012
    • (2012) J Biol Chem , vol.287 , pp. 24378-24386
    • Ji, Y.1    Sun, S.2    Xia, S.3    Yang, L.4    Li, X.5    Qi, L.6
  • 50
    • 70350228797 scopus 로고    scopus 로고
    • Depotspecific differences in adipogenic progenitor abundance and proliferative response to high-fat diet
    • Joe AW, Yi L, Even Y, Vogl AW, Rossi FM. Depotspecific differences in adipogenic progenitor abundance and proliferative response to high-fat diet. Stem Cells 27: 2563-2570, 2009
    • (2009) Stem Cells , vol.27 , pp. 2563-2570
    • Joe, A.W.1    Yi, L.2    Even, Y.3    Vogl, A.W.4    Rossi, F.M.5
  • 52
    • 44449145060 scopus 로고    scopus 로고
    • Visceral fat accumulation induced by a high-fat diet causes the atrophy of mesenteric lymph nodes in obese mice
    • Kim CS, Lee SC, Kim YM, Kim BS, Choi HS, Kawada T, Kwon BS, Yu R. Visceral fat accumulation induced by a high-fat diet causes the atrophy of mesenteric lymph nodes in obese mice. Obesity (Silver Spring) 16: 1261-1269, 2008
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1261-1269
    • Kim, C.S.1    Lee, S.C.2    Kim, Y.M.3    Kim, B.S.4    Choi, H.S.5    Kawada, T.6    Kwon, B.S.7    Yu, R.8
  • 54
    • 0000644552 scopus 로고
    • Die Ätiologie der Milzbrand-Krankheit, begründet auf die Entwicklungsgeschichte des Bacillus anthracis
    • Koch Untersuchungen über Bakterien
    • Koch Untersuchungen über Bakterien: VR. Die Ätiologie der Milzbrand-Krankheit, begründet auf die Entwicklungsgeschichte des Bacillus anthracis. Cohns Beitrage zur Biologie der Pflanzen 2: 277-310, 1876
    • (1876) Cohns Beitrage Zur Biologie Der Pflanzen , vol.2 , pp. 277-310
  • 56
    • 33847637510 scopus 로고    scopus 로고
    • Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue
    • Konrad D, Rudich A, Schoenle EJ. Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue. Diabetologia 50: 833-839, 2007
    • (2007) Diabetologia , vol.50 , pp. 833-839
    • Konrad, D.1    Rudich, A.2    Schoenle, E.J.3
  • 57
  • 59
    • 79151473768 scopus 로고    scopus 로고
    • The use of adipose tissue-conditioned media to demonstrate the differential effects of fat depots on insulin-stimulated glucose uptake in a skeletal muscle cell line
    • Lam YY, Janovska A, McAinch AJ, Belobrajdic DP, Hatzinikolas G, Game P, Wittert GA. The use of adipose tissue-conditioned media to demonstrate the differential effects of fat depots on insulin-stimulated glucose uptake in a skeletal muscle cell line. Obes Res Clin Pract 5: e1-e78, 2011
    • (2011) Obes Res Clin Pract , vol.5
    • Lam, Y.Y.1    Janovska, A.2    McAinch, A.J.3    Belobrajdic, D.P.4    Hatzinikolas, G.5    Game, P.6    Wittert, G.A.7
  • 60
    • 84859159458 scopus 로고    scopus 로고
    • Postprandial metabolism of meal triglyceride in humans
    • Lambert JE, Parks EJ. Postprandial metabolism of meal triglyceride in humans. Biochim Biophys Acta 1821: 721-726, 2012
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 721-726
    • Lambert, J.E.1    Parks, E.J.2
  • 64
    • 34249650125 scopus 로고    scopus 로고
    • Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences
    • Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol 47: 142-156, 2007
    • (2007) J Hepatol , vol.47 , pp. 142-156
    • Leclercq, I.A.1    Da Silva Morais, A.2    Schroyen, B.3    van Hul, N.4    Geerts, A.5
  • 65
    • 84880317157 scopus 로고    scopus 로고
    • The effect of high-fat diet-induced pathophysiological changes in the gut on obesity: What Should be the ideal treatment?
    • Lee Y. The effect of high-fat diet-induced pathophysiological changes in the gut on obesity: What Should be the ideal treatment? Clin Trans Gastroenterol 4: e39, 2013
    • (2013) Clin Trans Gastroenterol , vol.4
    • Lee, Y.1
  • 66
    • 12444334643 scopus 로고    scopus 로고
    • Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
    • Lelliott C, Vidal-Puig AJ. Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord 28, Suppl 4: S22-S28, 2004
    • (2004) Int J Obes Relat Metab Disord , vol.28 , Issue.SUPPL. 54
    • Lelliott, C.1    Vidal-Puig, A.J.2
  • 68
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 444: 1022-1023, 2006
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 71
    • 84883259378 scopus 로고    scopus 로고
    • Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism
    • Luche E, Cousin B, Garidou L, Serino M, Waget A, Barreau C, Andre M, Valet P, Courtney M, Casteilla L, Burcelin R. Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism. Mol Metab 2: 281-291, 2013
    • (2013) Mol Metab , vol.2 , pp. 281-291
    • Luche, E.1    Cousin, B.2    Garidou, L.3    Serino, M.4    Waget, A.5    Barreau, C.6    Andre, M.7    Valet, P.8    Courtney, M.9    Casteilla, L.10    Burcelin, R.11
  • 72
  • 73
    • 5044228305 scopus 로고    scopus 로고
    • Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation
    • Ma Y, Liu H, Tu-Rapp H, Thiesen HJ, Ibrahim SM, Cole SM, Pope RM. Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation. Nat Immunol 5: 380-387, 2004
    • (2004) Nat Immunol , vol.5 , pp. 380-387
    • Ma, Y.1    Liu, H.2    Tu-Rapp, H.3    Thiesen, H.J.4    Ibrahim, S.M.5    Cole, S.M.6    Pope, R.M.7
  • 74
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson AJ, Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303: 1662-1665, 2004
    • (2004) Science , vol.303 , pp. 1662-1665
    • Macpherson, A.J.1    Uhr, T.2
  • 75
    • 78650465542 scopus 로고    scopus 로고
    • Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk
    • Manco M, Putignani L, Bottazzo GF. Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. Endocr Rev 31: 817-844, 2010
    • (2010) Endocr Rev , vol.31 , pp. 817-844
    • Manco, M.1    Putignani, L.2    Bottazzo, G.F.3
  • 76
    • 33846207822 scopus 로고    scopus 로고
    • Adaptive immunity: Care for the community
    • McFall-Ngai M. Adaptive immunity: care for the community. Nature 445: 153, 2007
    • (2007) Nature , vol.445 , pp. 153
    • McFall-Ngai, M.1
  • 78
    • 24144473122 scopus 로고    scopus 로고
    • Counterpoint: Visceral adiposity is not causally related to insulin resistance
    • Miles JM, Jensen MD. Counterpoint: visceral adiposity is not causally related to insulin resistance. Diabetes Care 28: 2326-2328, 2005
    • (2005) Diabetes Care , vol.28 , pp. 2326-2328
    • Miles, J.M.1    Jensen, M.D.2
  • 82
    • 50949108719 scopus 로고    scopus 로고
    • Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
    • Murano I, Barbatelli G, Parisani V, Latini C, Muzzonigro G, Castellucci M, Cinti S. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 49: 1562-1568, 2008
    • (2008) J Lipid Res , vol.49 , pp. 1562-1568
    • Murano, I.1    Barbatelli, G.2    Parisani, V.3    Latini, C.4    Muzzonigro, G.5    Castellucci, M.6    Cinti, S.7
  • 84
    • 59849113547 scopus 로고    scopus 로고
    • Microbes in gastrointestinal health and disease
    • Neish AS. Microbes in gastrointestinal health and disease. Gastroenterology 136: 65-80, 2009
    • (2009) Gastroenterology , vol.136 , pp. 65-80
    • Neish, A.S.1
  • 87
    • 0022408652 scopus 로고
    • The influence of body fat distribution on the incidence of diabetes mellitus. 135 years of follow- up of the participants in the study of men born in 1913
    • Ohlson LO, Larsson B, Svardsudd K, Welin L, Eriksson H, Wilhelmsen L, Bjorntorp P, Tibblin G. The influence of body fat distribution on the incidence of diabetes mellitus. 135 years of follow- up of the participants in the study of men born in 1913. Diabetes 34: 1055-1058, 1985
    • (1985) Diabetes , vol.34 , pp. 1055-1058
    • Ohlson, L.O.1    Larsson, B.2    Svardsudd, K.3    Welin, L.4    Eriksson, H.5    Wilhelmsen, L.6    Bjorntorp, P.7    Tibblin, G.8
  • 90
    • 84893145824 scopus 로고    scopus 로고
    • Endothelial cells from visceral adipose tissue disrupt adipocyte functions in a three-dimensional setting: Partial rescue by angiopoietin- 1
    • Pellegrinelli V, Rouault C, Veyrie N, Clement K, Lacasa D. Endothelial cells from visceral adipose tissue disrupt adipocyte functions in a three-dimensional setting: partial rescue by angiopoietin- 1. Diabetes 63: 535-549, 2014
    • (2014) Diabetes , vol.63 , pp. 535-549
    • Pellegrinelli, V.1    Rouault, C.2    Veyrie, N.3    Clement, K.4    Lacasa, D.5
  • 92
    • 33947637709 scopus 로고    scopus 로고
    • Preadipocyte response and impairment of differentiation in an inflammatory environment
    • Poulain-Godefroy O, Froguel P. Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun 356: 662-667, 2007
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 662-667
    • Poulain-Godefroy, O.1    Froguel, P.2
  • 94
    • 33847147251 scopus 로고    scopus 로고
    • Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages
    • Ramana KV, Srivastava SK. Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine 36: 115-122, 2006
    • (2006) Cytokine , vol.36 , pp. 115-122
    • Ramana, K.V.1    Srivastava, S.K.2
  • 95
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332: 974-977, 2011
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3    Tran, G.4    Jabri, B.5    Chatila, T.A.6    Mazmanian, S.K.7
  • 96
    • 78751494530 scopus 로고    scopus 로고
    • The portal theory supported by venous drainage-selective fat transplantation
    • Rytka JM, Wueest S, Schoenle EJ, Konrad D. The portal theory supported by venous drainage-selective fat transplantation. Diabetes 60: 56-63, 2011
    • (2011) Diabetes , vol.60 , pp. 56-63
    • Rytka, J.M.1    Wueest, S.2    Schoenle, E.J.3    Konrad, D.4
  • 98
    • 33847269251 scopus 로고    scopus 로고
    • Debugging how bacteria manipulate the immune response
    • Sansonetti PJ, Di Santo JP. Debugging how bacteria manipulate the immune response. Immunity 26: 149-161, 2007
    • (2007) Immunity , vol.26 , pp. 149-161
    • Sansonetti, P.J.1    Di Santo, J.P.2
  • 99
    • 34548531751 scopus 로고    scopus 로고
    • Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs
    • Schaffler A, Scholmerich J, Salzberger B. Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs. Trends Immunol 28: 393-399, 2007
    • (2007) Trends Immunol , vol.28 , pp. 393-399
    • Schaffler, A.1    Scholmerich, J.2    Salzberger, B.3
  • 101
    • 0036309971 scopus 로고    scopus 로고
    • Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists
    • Sewter CP, Blows F, Vidal-Puig A, O'Rahilly S. Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists. Diabetes 51: 718-723, 2002
    • (2002) Diabetes , vol.51 , pp. 718-723
    • Sewter, C.P.1    Blows, F.2    Vidal-Puig, A.3    O'Rahilly, S.4
  • 102
    • 35148866159 scopus 로고    scopus 로고
    • The effect of fat removal on glucose tolerance is depot specific in male and female mice
    • Shi H, Strader AD, Woods SC, Seeley RJ. The effect of fat removal on glucose tolerance is depot specific in male and female mice. Am J Physiol Endocrinol Metab 293: E1012-E1020, 2007
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Shi, H.1    Strader, A.D.2    Woods, S.C.3    Seeley, R.J.4
  • 103
    • 33947502786 scopus 로고    scopus 로고
    • Relationship between adipocyte size and adipokine expression and secretion
    • Skurk T, Alberti-Huber C, Herder C, Hauner H. Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92: 1023-1033, 2007
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1023-1033
    • Skurk, T.1    Alberti-Huber, C.2    Herder, C.3    Hauner, H.4
  • 104
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, Kim JB. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346: 739-745, 2006
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 105
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 45: 42-72, 2006
    • (2006) Prog Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 106
    • 84872327440 scopus 로고    scopus 로고
    • Pathophysiology of human visceral obesity: An update
    • Tchernof A, Despres JP. Pathophysiology of human visceral obesity: an update. Physiol Rev 93: 359-404, 2013
    • (2013) Physiol Rev , vol.93 , pp. 359-404
    • Tchernof, A.1    Despres, J.P.2
  • 108
    • 77950296018 scopus 로고    scopus 로고
    • Transplantation of adipose tissue and stem cells: Role in metabolism and disease
    • Tran TT, Kahn CR. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nature Rev 6: 195-213, 2010
    • (2010) Nature Rev , vol.6 , pp. 195-213
    • Tran, T.T.1    Kahn, C.R.2
  • 109
    • 42649144463 scopus 로고    scopus 로고
    • Beneficial effects of subcutaneous fat transplantation on metabolism
    • Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 7: 410-420, 2008
    • (2008) Cell Metab , vol.7 , pp. 410-420
    • Tran, T.T.1    Yamamoto, Y.2    Gesta, S.3    Kahn, C.R.4
  • 111
    • 84876673360 scopus 로고    scopus 로고
    • Insulin resistance: An adaptive mechanism becomes maladaptive in the current environment: An evolutionary perspective
    • Tsatsoulis A, Mantzaris MD, Bellou S, Andrikoula M. Insulin resistance: an adaptive mechanism becomes maladaptive in the current environment: an evolutionary perspective. Metabolism 62: 622-633, 2013
    • (2013) Metabolism , vol.62 , pp. 622-633
    • Tsatsoulis, A.1    Mantzaris, M.D.2    Bellou, S.3    Andrikoula, M.4
  • 112
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • Turnbaugh PJ, Backhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3: 213-223, 2008
    • (2008) Cell Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Backhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 114
    • 0017331682 scopus 로고
    • Intestinal lymph flow and lymphatic transport of protein during fat absorption
    • Turner SG, Barrowman JA. Intestinal lymph flow and lymphatic transport of protein during fat absorption. Q J Exp Physiol Cogn Med Sci 62: 175-180, 1977
    • (1977) Q J Exp Physiol Cogn Med Sci , vol.62 , pp. 175-180
    • Turner, S.G.1    Barrowman, J.A.2
  • 115
    • 77049292123 scopus 로고
    • The degree of masculine differentiation of obesities: A factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease
    • Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr 4: 20-34, 1956
    • (1956) Am J Clin Nutr , vol.4 , pp. 20-34
    • Vague, J.1
  • 116
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome: An allostatic perspective
    • Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome: an allostatic perspective. Biochim Biophys Acta 1801: 338-349, 2010
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 117
    • 77955751803 scopus 로고    scopus 로고
    • Lymphatic system and associated adipose tissue in the development of inflammatory bowel disease
    • von der Weid PY, Rainey KJ. Lymphatic system and associated adipose tissue in the development of inflammatory bowel disease. Aliment Pharmacol Ther 32: 697-711, 2010
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 697-711
    • von der Weid, P.Y.1    Rainey, K.J.2
  • 120
    • 84890555675 scopus 로고    scopus 로고
    • Lipopolysaccharides reduce adipogenesis in 3T3-L1 adipocytes through activation of NF-kappaB pathway and downregulation of AMPK expression
    • Wang L, Li L, Ran X, Long M, Zhang M, Tao Y, Luo X, Wang Y, Jiao Y, Mao X, Ren J. Lipopolysaccharides reduce adipogenesis in 3T3-L1 adipocytes through activation of NF-kappaB pathway and downregulation of AMPK expression. Cardiovasc Toxicol 13: 338-346, 2013
    • (2013) Cardiovasc Toxicol , vol.13 , pp. 338-346
    • Wang, L.1    Li, L.2    Ran, X.3    Long, M.4    Zhang, M.5    Tao, Y.6    Luo, X.7    Wang, Y.8    Jiao, Y.9    Mao, X.10    Ren, J.11
  • 122
    • 84880981676 scopus 로고    scopus 로고
    • Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance
    • Wiedemann MS, Wueest S, Item F, Schoenle EJ, Konrad D. Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance. Am J Physiol Endocrinol Metab 305: E388-E395, 2013
    • (2013) Am J Physiol Endocrinol Metab , vol.305
    • Wiedemann, M.S.1    Wueest, S.2    Item, F.3    Schoenle, E.J.4    Konrad, D.5
  • 123
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433, 1990
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 126
    • 59449097943 scopus 로고    scopus 로고
    • Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high-fat fed mice
    • Wueest S, Rapold RA, Rytka JM, Schoenle EJ, Konrad D. Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high-fat fed mice. Diabetologia 52: 541-546, 2009
    • (2009) Diabetologia , vol.52 , pp. 541-546
    • Wueest, S.1    Rapold, R.A.2    Rytka, J.M.3    Schoenle, E.J.4    Konrad, D.5
  • 127
    • 84906912775 scopus 로고    scopus 로고
    • Depot-specific differences in adipocyte insulin sensitivity in mice are diet- and function-dependent
    • Wueest S, Schoenle EJ, Konrad D. Depot-specific differences in adipocyte insulin sensitivity in mice are diet- and function-dependent. Adipocyte 1: 153-156, 2012
    • (2012) Adipocyte , vol.1 , pp. 153-156
    • Wueest, S.1    Schoenle, E.J.2    Konrad, D.3
  • 130
    • 0033543754 scopus 로고    scopus 로고
    • Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1
    • Xu H, Sethi JK, Hotamisligil GS. Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1. J Biol Chem 274: 26287-26295, 1999
    • (1999) J Biol Chem , vol.274 , pp. 26287-26295
    • Xu, H.1    Sethi, J.K.2    Hotamisligil, G.S.3
  • 132
    • 34247855853 scopus 로고    scopus 로고
    • Adipose tissue distribution and risk of metabolic disease: Does thiazolidinedioneinduced adipose tissue redistribution provide a clue to the answer?
    • Yang X, Smith U. Adipose tissue distribution and risk of metabolic disease: does thiazolidinedioneinduced adipose tissue redistribution provide a clue to the answer? Diabetologia 50: 1127-1139, 2007
    • (2007) Diabetologia , vol.50 , pp. 1127-1139
    • Yang, X.1    Smith, U.2
  • 134
    • 41549167707 scopus 로고    scopus 로고
    • Effects of medium-chain triglycerides, long-chain triglycerides, or 2-monododecanoin on fatty acid composition in the portal vein, intestinal lymph, and systemic circulation in rats
    • You YQ, Ling PR, Qu JZ, Bistrian BR. Effects of medium-chain triglycerides, long-chain triglycerides, or 2-monododecanoin on fatty acid composition in the portal vein, intestinal lymph, and systemic circulation in rats. JPEN J Parenter Enteral Nutr 32: 169-175, 2008
    • (2008) JPEN J Parenter Enteral Nutr , vol.32 , pp. 169-175
    • You, Y.Q.1    Ling, P.R.2    Qu, J.Z.3    Bistrian, B.R.4
  • 135
    • 33750602672 scopus 로고    scopus 로고
    • Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice
    • Yu R, Kim CS, Kwon BS, Kawada T. Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity (Silver Spring) 14: 1353-1362, 2006
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 1353-1362
    • Yu, R.1    Kim, C.S.2    Kwon, B.S.3    Kawada, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.