Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

Archives of Biochemistry and Biophysics

Volumn 559, Issue , 2014, Pages 53-61

  Qin, Si ^a,b   Deng, Fangming ^a   Wu, Weiguo ^a   Jiang, Liwen ^a   Yamashiro, Takaaki ^b   Yano, Satoshi ^b   Hou, De Xing ^a,b  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Baicalein; Keap1 modification; Nrf2 ubiquitination; Nrf2 Keap1 system

Indexed keywords

ALPHA TUBULIN; BAICALEIN; CYCLOHEXIMIDE; JANUS KINASE 1; JANUS KINASE 2; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CANCER CELL; CANCER PREVENTION; CELL PROTECTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

SCUTELLARIA BAICALENSIS;

BAICALEIN; KEAP1 MODIFICATION; NRF2 UBIQUITINATION; NRF2/KEAP1 SYSTEM;

ANTIOXIDANTS; CHEMOPREVENTION; CYTOPROTECTION; FLAVANONES; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PHOSPHORYLATION; PROTEIN KINASES; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC; UBIQUITINATION;

EID: 84906790394     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2014.03.011     Document Type: Article

References (54)

1. M. Li-Weber Cancer Treat. Rev. 35 2009 57 68
2. J.I. Chao, W.C. Su, and H.F. Liu Mol. Cancer Ther. 6 2007 3039 3048
3. G. Donald, K. Hertzer, and G. Eibl Curr. Drug Targets 13 2012 1772 1776
4. G.P. Pidgeon, M. Kandouz, A. Meram, and K.V. Honn Cancer Res. 62 2002 2721 2727
5. S. Qin, J. Chen, S. Tanigawa, and D.X. Hou J. Ethnopharmacol. 140 2012 131 140
6. A.T. Dinkova-Kostova, W.D. Holtzclaw, R.N. Cole, K. Itoh, N. Wakabayashi, Y. Katoh, M. Yamamoto, and P. Talalay Proc. Natl. Acad. Sci. USA 99 2002 11908 11913
7. H. Motohashi, and M. Yamamoto Trends Mol. Med. 10 2004 549 557
8. T.W. Kensler, N. Wakabayashi, and S. Biswal Annu. Rev. Pharmacol. Toxicol. 47 2007 89 116
9. J.D. Hayes, M. McMahon, S. Chowdhry, and A.T. Dinkova-Kostova Antioxid. Redox Signal. 13 2010 1713 1748
10. L. Baird, and A.T. Dinkova-Kostova Arch. Toxicol. 85 2011 241 272
11. D.D. Zhang, and M. Hannink Mol. Cell. Biol. 23 2003 8137 8151
12. H.C. Huang, T. Nguyen, and C.B. Pickett J. Biol. Chem. 277 2002 42769 42774
13. R. Yu, W. Lei, S. Mandlekar, M.J. Weber, C.J. Der, J. Wu, and A.N. Kong J. Biol. Chem. 274 1999 27545 27552
14. J.M. Lee, J.M. Hanson, W.A. Chu, and J.A. Johnson J. Biol. Chem. 276 2001 20011 20016
15. S.B. Cullinan, D. Zhang, M. Hannink, E. Arvisais, R.J. Kaufman, and J.A. Diehl Mol. Cell. Biol. 23 2003 7198 7209
16. J. Pi, Y. Bai, J.M. Reece, J. Williams, D. Liu, M.L. Freeman, W.E. Fahl, D. Shugar, J. Liu, W. Qu, S. Collins, and M.P. Waalkes Free Radic. Biol. Med. 42 2007 1797 1806
17. T. Kumamoto, M. Fujii, and D.X. Hou Cancer Lett. 275 2009 17 26
18. S.A. Rushworth, L. Zaitseva, M.Y. Murray, N.M. Shah, K.M. Bowles, and D.J. MacEwan Blood 120 2012 5188 5198
19. T. Ohtsubo, S. Kamada, T. Mikami, H. Murakami, and Y. Tsujimoto Cell Death Differ. 6 1999 865 872
20. G.M. DeNicola, F.A. Karreth, T.J. Humpton, A. Gopinathan, C. Wei, K. Frese, D. Mangal, K.H. Yu, C.J. Yeo, E.S. Calhoun, F. Scrimieri, J.M. Winter, R.H. Hruban, C. Iacobuzio-Donahue, S.E. Kern, I.A. Blair, and D.A. Tuveson Nature 475 2011 106 109
21. C. Sangokoya, M.J. Telen, and J.T. Chi Blood 116 2010 4338 4348
22. W. Miao, L. Hu, P.J. Scrivens, and G. Batist J. Biol. Chem. 280 2005 20340 20348
23. B. Ramachandran, G. Yu, and T. Gulick J. Biol. Chem. 283 2008 11935 11946
24. S. Tanigawa, M. Fujii, and D.X. Hou Free Radic. Biol. Med. 42 2007 1690 1703
25. S. Qin, J. Chen, S. Tanigawa, and D.X. Hou Mol. Nutr. Food Res. 57 2013 435 446
26. K. Itoh, K.I. Tong, and M. Yamamoto Free Radic. Biol. Med. 36 2004 1208 1213
27. J.W. Kaspar, S.K. Niture, and A.K. Jaiswal Free Radic. Biol. Med. 47 2009 1304 1309
28. A.L. Eggler, G. Liu, J.M. Pezzuto, R.B. van Breemen, and A.D. Mesecar Proc. Natl. Acad. Sci. USA 102 2005 10070 10075
29. K.I. Tong, Y. Katoh, H. Kusunoki, K. Itoh, T. Tanaka, and M. Yamamoto Mol. Cell. Biol. 26 2006 2887 2900
30. K.W. Kang, S.J. Lee, J.W. Park, and S.G. Kim Mol. Pharmacol. 62 2002 1001 1010
31. C. Xu, X. Yuan, Z. Pan, G. Shen, J.H. Kim, S. Yu, T.O. Khor, W. Li, J. Ma, and A.N. Kong Mol. Cancer Ther. 5 2006 1918 1926
32. D.A. Bloom, and A.K. Jaiswal J. Biol. Chem. 278 2003 44675 44682
33. P. Rada, A.I. Rojo, N. Evrard-Todeschi, N.G. Innamorato, A. Cotte, T. Jaworski, J.C. Tobon-Velasco, H. Devijver, M.F. Garcia-Mayoral, F. Van Leuven, J.D. Hayes, G. Bertho, and A. Cuadrado Mol. Cell. Biol. 32 2012 3486 3499
34. S. Chowdhry, Y. Zhang, M. McMahon, C. Sutherland, A. Cuadrado, and J.D. Hayes Oncogene 32 2013 3765 3781
35. J.W. Kaspar, and A.K. Jaiswal FASEB J. 25 2011 1076 1087
36. H.J. Kang, Y.B. Hong, H.J. Kim, and I. Bae J. Biol. Chem. 285 2010 21258 21268
37. E. Portales-Casamar, S. Thongjuea, A.T. Kwon, D. Arenillas, X. Zhao, E. Valen, D. Yusuf, B. Lenhard, W.W. Wasserman, and A. Sandelin Nucleic Acids Res. 38 2010 D105 D110
38. D. Papp, K. Lenti, D. Modos, D. Fazekas, Z. Dul, D. Turei, L. Foldvari-Nagy, R. Nussinov, P. Csermely, and T. Korcsmaros FEBS Lett. 586 2012 1795 1802
39. R. Venugopal, and A.K. Jaiswal Oncogene 17 1998 3145 3156
40. M. Sakai, M.S. Serria, H. Ikeda, K. Yoshida, J. Imaki, and S. Nishi Nucleic Acids Res. 29 2001 1228 1237
41. J. Ninomiya-Tsuji, K. Kishimoto, A. Hiyama, J. Inoue, Z. Cao, and K. Matsumoto Nature 398 1999 252 256
42. C.S. Mitsiades, N. Mitsiades, V. Poulaki, R. Schlossman, M. Akiyama, D. Chauhan, T. Hideshima, S.P. Treon, N.C. Munshi, P.G. Richardson, and K.C. Anderson Oncogene 21 2002 5673 5683
43. J.R. Spence, M. Madhavan, J.C. Aycinena, and K. Del Rio-Tsonis Mol. Vis. 13 2007 57 65
44. Y.T. Ip, and R.J. Davis Curr. Opin. Cell Biol. 10 1998 205 219
45. J. Downward Curr. Opin. Cell Biol. 10 1998 262 267
46. A.M. Martelli, P.L. Tazzari, G. Tabellini, R. Bortul, A.M. Billi, L. Manzoli, A. Ruggeri, R. Conte, and L. Cocco Leukemia 17 2003 1794 1805
47. L.L. Belyanskaya, S. Hopkins-Donaldson, S. Kurtz, A.P. Simoes-Wust, S. Yousefi, H.U. Simon, R. Stahel, and U. Zangemeister-Wittke Int. J. Cancer 117 2005 755 763
48. Y. Miyata, T. Sato, M. Yano, and A. Ito Mol. Cancer Ther. 3 2004 839 847
49. C.W. Lin, M.J. Wu, I.Y. Liu, J.D. Su, and J.H. Yen J. Agric. Food Chem. 58 2010 4477 4486
50. M. Lorenz, S. Wessler, E. Follmann, W. Michaelis, T. Dusterhoft, G. Baumann, K. Stangl, and V. Stangl J. Biol. Chem. 279 2004 6190 6195
51. T. Akao, K. Kawabata, E. Yanagisawa, K. Ishihara, Y. Mizuhara, Y. Wakui, Y. Sakashita, and K. Kobashi J. Pharm. Pharmacol. 52 2000 1563 1568
52. M.Y. Lai, S.L. Hsiu, S.Y. Tsai, Y.C. Hou, and P.D. Chao J. Pharm. Pharmacol. 55 2003 205 209
53. A. Ishisaka, K. Kawabata, S. Miki, Y. Shiba, S. Minekawa, T. Nishikawa, R. Mukai, J. Terao, and Y. Kawai PLoS ONE 8 2013 e80843
54. K. Shimoi, N. Saka, R. Nozawa, M. Sato, I. Amano, T. Nakayama, and N. Kinae Drug Metab. Dispos. 29 2001 1521 1524