메뉴 건너뛰기




Volumn 8, Issue 11, 2013, Pages

Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL TRANSPORT; CALCIUM; CELL LINE; GLUCURONIDASE; HUMANS; INFLAMMATION; MACROPHAGES; MICE; MITOCHONDRIA; QUERCETIN;

EID: 84894133414     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080843     Document Type: Article
Times cited : (94)

References (50)
  • 1
    • 0001868668 scopus 로고
    • Vitamin P: Flavonols as vitamins
    • doi:10.1038/138027b0
    • Rusznyak ST, Szent-Gyorgyi A (1936) Vitamin P: flavonols as vitamins. Nature 138: 27. doi:10.1038/138027b0.
    • (1936) Nature , vol.138 , pp. 27
    • Rusznyak, S.T.1    Szent-Gyorgyi, A.2
  • 2
    • 51149186854 scopus 로고
    • Vitamin nature of flavones
    • doi:10.1038/138798a0
    • Bentsath A, Rusznyak ST, Szent-Gyorgyi A (1936) Vitamin nature of flavones. Nature 138: 798. doi:10.1038/138798a0.
    • (1936) Nature , vol.138 , pp. 798
    • Bentsath, A.1    Rusznyak, S.T.2    Szent-Gyorgyi, A.3
  • 3
    • 33751391867 scopus 로고
    • Content of Potentially Anticarcinogenic Flavonoids of 28 Vegetables and 9 Fruits Commonly Consumed in The Netherlands
    • Hertog MG, Hollman PC, Katan MB (1992) Content of Potentially Anticarcinogenic Flavonoids of 28 Vegetables and 9 Fruits Commonly Consumed in The Netherlands. J Agr Food Chem 40: 2379-2383.
    • (1992) J Agr Food Chem , vol.40 , pp. 2379-2383
    • Hertog, M.G.1    Hollman, P.C.2    Katan, M.B.3
  • 4
    • 0347197907 scopus 로고
    • Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
    • Hertog PG, Hollman PC, van de Putte B (1993) Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. J Agr Food Chem 41: 1242-1246.
    • (1993) J Agr Food Chem , vol.41 , pp. 1242-1246
    • Hertog, P.G.1    Hollman, P.C.2    Van De Putte, B.3
  • 5
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands
    • Hertog MG, Hollman PC, Katan MB, Kromhout D (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 20: 21-29. doi: 10.1080/01635589309514267. PubMed: 8415127. (Pubitemid 23225364)
    • (1993) Nutrition and Cancer , vol.20 , Issue.1 , pp. 21-29
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3    Kromhout, D.4
  • 6
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study
    • DOI 10.1016/0140-6736(93)92876-U
    • Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011. doi:10.1016/0140-6736(93)92876-U. PubMed: 8105262. (Pubitemid 23314801)
    • (1993) Lancet , vol.342 , Issue.8878 , pp. 1007-1011
    • Hertog, M.G.L.1    Feskens, E.J.M.2    Hollman, P.C.H.3    Katan, M.B.4    Kromhout, D.5
  • 8
    • 0028925089 scopus 로고
    • Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study
    • doi:10.1001/archinte.1995.00430040053006. PubMed: 7848021
    • Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R et al. (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 155: 381-386. doi:10.1001/archinte.1995. 00430040053006. PubMed: 7848021.
    • (1995) Arch Intern Med , vol.155 , pp. 381-386
    • Hertog, M.G.1    Kromhout, D.2    Aravanis, C.3    Blackburn, H.4    Buzina, R.5
  • 10
    • 0029868401 scopus 로고    scopus 로고
    • Dietary flavonoids, antioxidant vitamins, and incidence of stroke: The Zutphen study
    • DOI 10.1001/archinte.156.6.637
    • Keli SO, Hertog MG, Feskens EJ, Kromhout D (1996) Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 156: 637-642. doi:10.1001/archinte.156.6.637. PubMed: 8629875. (Pubitemid 26095013)
    • (1996) Archives of Internal Medicine , vol.156 , Issue.6 , pp. 637-642
    • Keli, S.O.1    Hertog, M.G.L.2    Feskens, E.J.M.3    Kromhout, D.4
  • 13
    • 0036725818 scopus 로고    scopus 로고
    • Risk factors for Alzheimer's disease: A prospective analysis from the Canadian Study of Health and Aging
    • DOI 10.1093/aje/kwf074
    • Lindsay J, Laurin D, Verreault R, Hébert R, Helliwell B et al. (2002) Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156: 445-453. doi:10.1093/aje/kwf074. PubMed: 12196314. (Pubitemid 34976983)
    • (2002) American Journal of Epidemiology , vol.156 , Issue.5 , pp. 445-453
    • Lindsay, J.1    Laurin, D.2    Verreault, R.3    Hebert, R.4    Helliwell, B.5    Hill, G.B.6    McDowell, I.7
  • 14
    • 25444446804 scopus 로고    scopus 로고
    • Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage
    • DOI 10.1016/j.freeradbiomed.2005.05.024, PII S0891584905002996
    • Sakano K, Mizutani M, Murata M, Oikawa S, Hiraku Y et al. (2005) Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. Free Radic Biol Med 39: 1041-1049. doi:10.1016/j.freeradbiomed.2005.05.024. PubMed: 16198231. (Pubitemid 41356720)
    • (2005) Free Radical Biology and Medicine , vol.39 , Issue.8 , pp. 1041-1049
    • Sakano, K.1    Mizutani, M.2    Murata, M.3    Oikawa, S.4    Hiraku, Y.5    Kawanishi, S.6
  • 15
    • 0141957301 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA
    • DOI 10.1016/S0006-2952(03)00541-0
    • Furukawa A, Oikawa S, Murata M, Hiraku Y, Kawanishi S (2003) (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular. DNA - Biochem Pharmacol 66: 1769-1778. doi:10.1016/S0006-2952(03)00541-0. (Pubitemid 37249321)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.9 , pp. 1769-1778
    • Furukawa, A.1    Oikawa, S.2    Murata, M.3    Hiraku, Y.4    Kawanishi, S.5
  • 16
    • 0034493221 scopus 로고    scopus 로고
    • Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin
    • Yamashita N, Kawanishi S (2000) Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin. Free Radic Res 33: 623-633. doi:10.1080/10715760000301141. PubMed: 11200093. (Pubitemid 32103702)
    • (2000) Free Radical Research , vol.33 , Issue.5 , pp. 623-633
    • Yamashita, N.1    Kawanishi, S.2
  • 17
    • 24144464518 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells
    • DOI 10.1093/carcin/bgi104
    • Kim M, Murakami A, Kawabata K, Ohigashi H (2005) (-)-Epigallocatechin-3- gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. Carcinogenesis 26: 1553-1562. doi:10.1093/carcin/bgi104. PubMed: 15860507. (Pubitemid 41236048)
    • (2005) Carcinogenesis , vol.26 , Issue.9 , pp. 1553-1562
    • Kim, M.1    Murakami, A.2    Kawabata, K.3    Ohigashi, H.4
  • 18
    • 19044388959 scopus 로고    scopus 로고
    • In vitro biological properties of flavonoid conjugates found in vivo
    • DOI 10.1080/10715760500053610
    • Williamson G, Barron D, Shimoi K, Terao J (2005) In vitro biological properties of flavonoid conjugates found in vivo. Free Radic Res 39: 457-469. doi:10.1080/10715760500053610. PubMed: 16036321. (Pubitemid 40711878)
    • (2005) Free Radical Research , vol.39 , Issue.5 , pp. 457-469
    • Williamson, G.1    Barron, D.2    Shimoi, K.3    Terao, J.4
  • 19
    • 0035692180 scopus 로고    scopus 로고
    • Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin
    • Day AJ, Mellon F, Barron D, Sarrazin G, Morgan MR et al. (2001) Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res 35: 941-952. doi:10.1080/10715760100301441. PubMed: 11811545. (Pubitemid 34065683)
    • (2001) Free Radical Research , vol.35 , Issue.6 , pp. 941-952
    • Day, A.J.1    Mellon, F.2    Barron, D.3    Sarrazin, G.4    Morgan, M.R.A.5    Williamson, G.6
  • 20
    • 0033843864 scopus 로고    scopus 로고
    • Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols
    • Kim S, Lee MJ, Hong J, Li C, Smith TJ et al. (2000) Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols. Nutr Cancer 37: 41-48. doi:10.1207/S15327914NC3701-5. PubMed: 10965518. (Pubitemid 30650665)
    • (2000) Nutrition and Cancer , vol.37 , Issue.1 , pp. 41-48
    • Kim, S.1    Lee, M.-J.2    Hong, J.3    Li, C.4    Smith, T.J.5    Yang, G.-Y.6    Seril, D.N.7    Yang, C.S.8
  • 22
    • 49449084484 scopus 로고    scopus 로고
    • Tissue distribution of quercetin in pigs after long-term dietary supplementation
    • PubMed: 18641184
    • Bieger J, Cermak R, Blank R, de Boer VC, Hollman PC et al. (2008) Tissue distribution of quercetin in pigs after long-term dietary supplementation. J Nutr 138: 1417-1420. PubMed: 18641184.
    • (2008) J Nutr , vol.138 , pp. 1417-1420
    • Bieger, J.1    Cermak, R.2    Blank, R.3    De Boer, V.C.4    Hollman, P.C.5
  • 23
    • 15844419387 scopus 로고    scopus 로고
    • Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit
    • DOI 10.1080/10715760400019638
    • Kamada C, da Silva EL, Ohnishi-Kameyama M, Moon JH, Terao J (2005) Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit. Free Radic Res 39: 185-194. doi:10.1080/10715760400019638. PubMed: 15763966. (Pubitemid 40425740)
    • (2005) Free Radical Research , vol.39 , Issue.2 , pp. 185-194
    • Kamada, C.1    Da, S.E.L.2    Ohnishi-Kameyama, M.3    Moon, J.-H.4    Terao, J.5
  • 24
    • 0035370769 scopus 로고    scopus 로고
    • Identification of quercetin 3-O-β-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin
    • DOI 10.1016/S0891-5849(01)00522-6, PII S0891584901005226
    • Moon JH, Tsushida T, Nakahara K, Terao J (2001) Identification of quercetin 3-O-β-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 30: 1274-1285. doi:10.1016/S0891-5849(01)00522-6. PubMed: 11368925. (Pubitemid 32463938)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.11 , pp. 1274-1285
    • Moon, J.-H.1    Tsushida, T.2    Nakahara, K.3    Terao, J.4
  • 25
    • 44049084958 scopus 로고    scopus 로고
    • Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the anti-atherosclerotic mechanism of dietary flavonoids
    • doi:10.1074/jbc.M706571200. PubMed: 18199750
    • Kawai Y, Nishikawa T, Shiba Y, Saito S, Murota K et al. (2008) Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 283: 9424-9434. doi:10.1074/jbc.M706571200. PubMed: 18199750.
    • (2008) J Biol Chem , vol.283 , pp. 9424-9434
    • Kawai, Y.1    Nishikawa, T.2    Shiba, Y.3    Saito, S.4    Murota, K.5
  • 26
    • 48849091582 scopus 로고    scopus 로고
    • (-)-Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: Implication in the anti-atherosclerotic actions of tea catechins
    • doi:10.1016/j.bbrc. 2008.07.086. PubMed: 18657514
    • Kawai Y, Tanaka H, Murota K, Naito M, Terao J (2008) (-)-Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: implication in the anti-atherosclerotic actions of tea catechins. Biochem Biophys Res Commun 374: 527-532. doi:10.1016/j.bbrc. 2008.07.086. PubMed: 18657514.
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 527-532
    • Kawai, Y.1    Tanaka, H.2    Murota, K.3    Naito, M.4    Terao, J.5
  • 27
    • 0037044751 scopus 로고    scopus 로고
    • A molecular sensor detects signal transduction from caveolae in living cells
    • DOI 10.1074/jbc.M205411200
    • Isshiki M, Ying YS, Fujita T, Anderson RG (2002) A molecular sensor detects signal transduction from caveolae in living cells. J Biol Chem 277: 43389-43398. doi:10.1074/jbc.M205411200. PubMed: 12177060. (Pubitemid 35285727)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.45 , pp. 43389-43398
    • Isshiki, M.1    Ying, Y.-S.2    Fujita, T.3    Anderson, R.G.W.4
  • 28
    • 80052269348 scopus 로고    scopus 로고
    • Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
    • doi:10.1016/j.freeradbiomed.2011.06.017. PubMed: 21741473
    • Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T et al. (2011) Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med 51: 1329-1336. doi:10.1016/j.freeradbiomed.2011.06.017. PubMed: 21741473.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1329-1336
    • Ishisaka, A.1    Ichikawa, S.2    Sakakibara, H.3    Piskula, M.K.4    Nakamura, T.5
  • 29
    • 0015529173 scopus 로고
    • The nature of the membrane sites controlling anion permeability of human red blood cells as determined by studies with disulfonic stilbene derivatives
    • doi:10.1007/BF01867863. PubMed: 4667922
    • Cabantchik ZI, Rothstein A (1972) The nature of the membrane sites controlling anion permeability of human red blood cells as determined by studies with disulfonic stilbene derivatives. J Membr Biol 10: 311-330. doi:10.1007/BF01867863. PubMed: 4667922.
    • (1972) J Membr Biol , vol.10 , pp. 311-330
    • Cabantchik, Z.I.1    Rothstein, A.2
  • 30
    • 78649376594 scopus 로고    scopus 로고
    • Distribution and functions of catechol-O-methyltransferase proteins: Do recent findings change the picture?
    • doi:10.1016/ B978-0-12-381326-8.00003-X. PubMed: 21095458
    • Myöhänen TT, Männistö PT (2010) Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? Int Rev Neurobiol 95: 29-47. doi:10.1016/ B978-0-12-381326-8.00003- X. PubMed: 21095458.
    • (2010) Int Rev Neurobiol , vol.95 , pp. 29-47
    • Myöhänen, T.T.1    Männistö, P.T.2
  • 33
    • 84855227974 scopus 로고    scopus 로고
    • 2+ by reactive oxygen species in osteoblasts treated with antimycin A
    • doi:10.1002/jat.1642. PubMed: 21381053
    • 2+ by reactive oxygen species in osteoblasts treated with antimycin A. J Appl Toxicol 32: 118-125. doi:10.1002/jat.1642. PubMed: 21381053.
    • (2012) J Appl Toxicol , vol.32 , pp. 118-125
    • Choi, E.M.1
  • 34
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • doi:10.1083/jcb.200809125. PubMed: 19029340
    • Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795-803. doi:10.1083/jcb.200809125. PubMed: 19029340.
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 35
    • 65349188107 scopus 로고    scopus 로고
    • Different profiles of quercetin metabolites in rat plasma: Comparison of two administration methods
    • doi:10.1271/bbb.80516. PubMed: 19270373
    • Kawai Y, Saito S, Nishikawa T, Ishisaka A, Murota K et al. (2009) Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods. Biosci Biotechnol Biochem 73: 517-523. doi:10.1271/bbb.80516. PubMed: 19270373.
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 517-523
    • Kawai, Y.1    Saito, S.2    Nishikawa, T.3    Ishisaka, A.4    Murota, K.5
  • 36
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • doi:10.1038/nature04723. PubMed: 16625205
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884. doi:10.1038/nature04723. PubMed: 16625205.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5
  • 37
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • doi:10.1038/nature04724. PubMed: 16625204
    • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y et al. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889. doi:10.1038/nature04724. PubMed: 16625204.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5
  • 38
    • 52749094770 scopus 로고    scopus 로고
    • Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    • doi:10.1016/j.cmet.2008.08.013. PubMed: 18840362
    • Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M et al. (2008) Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 8: 318-324. doi:10.1016/j.cmet.2008.08.013. PubMed: 18840362.
    • (2008) Cell Metab , vol.8 , pp. 318-324
    • Jung, H.S.1    Chung, K.W.2    Won Kim, J.3    Kim, J.4    Komatsu, M.5
  • 39
    • 77952409809 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
    • Albany NY PubMed: 20157526
    • Wu JJ, Quijano C, Chen E, Liu H, Cao L et al. (2009) Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany NY) 1: 425-437. PubMed: 20157526.
    • (2009) Aging , vol.1 , pp. 425-437
    • Wu, J.J.1    Quijano, C.2    Chen, E.3    Liu, H.4    Cao, L.5
  • 40
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • PubMed: 20173742
    • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A et al. (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12: 213-223. PubMed: 20173742.
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3    Taguchi, K.4    Kobayashi, A.5
  • 41
    • 79955377420 scopus 로고    scopus 로고
    • Autophagy-deficient mice develop multiple liver tumors
    • doi:10.1101/gad.2016211. PubMed: 21498569
    • Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C et al. (2011) Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25: 795-800. doi:10.1101/gad.2016211. PubMed: 21498569.
    • (2011) Genes Dev , vol.25 , pp. 795-800
    • Takamura, A.1    Komatsu, M.2    Hara, T.3    Sakamoto, A.4    Kishi, C.5
  • 42
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • doi:10.1038/ni.1980. PubMed: 21151103
    • Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T et al. (2011) Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 12: 222-230. doi:10.1038/ni.1980. PubMed: 21151103.
    • (2011) Nat Immunol , vol.12 , pp. 222-230
    • Nakahira, K.1    Haspel, J.A.2    Rathinam, V.A.3    Lee, S.J.4    Dolinay, T.5
  • 43
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • doi:10.1038/nature09663. PubMed: 21124315
    • Zhou R, Yazdi AS, Menu P, Tschopp J (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469: 221-225. doi:10.1038/nature09663. PubMed: 21124315.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 44
    • 84860705893 scopus 로고    scopus 로고
    • Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
    • doi:10.1038/nature10992. PubMed: 22535248
    • Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T et al. (2012) Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485: 251-255. doi:10.1038/nature10992. PubMed: 22535248.
    • (2012) Nature , vol.485 , pp. 251-255
    • Oka, T.1    Hikoso, S.2    Yamaguchi, O.3    Taneike, M.4    Takeda, T.5
  • 45
    • 77951498353 scopus 로고    scopus 로고
    • Mitochondria accumulate large amounts of quercetin: Prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid
    • doi:10.1016/j.jnutbio.2009.01.014. PubMed: 19278846
    • Fiorani M, Guidarelli A, Blasa M, Azzolini C, Candiracci M et al. (2010) Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid. J Nutr Biochem 21: 397-404. doi:10.1016/j.jnutbio.2009.01.014. PubMed: 19278846.
    • (2010) J Nutr Biochem , vol.21 , pp. 397-404
    • Fiorani, M.1    Guidarelli, A.2    Blasa, M.3    Azzolini, C.4    Candiracci, M.5
  • 46
    • 84868026885 scopus 로고    scopus 로고
    • Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins
    • doi:10.4161/cc.22027. PubMed: 23070521
    • Pietrocola F, Mariño G, Lissa D, Vacchelli E, Malik SA et al. (2012) Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins. Cell Cycle 11: 3851-3860. doi:10.4161/cc.22027. PubMed: 23070521.
    • (2012) Cell Cycle , vol.11 , pp. 3851-3860
    • Pietrocola, F.1    Mariño, G.2    Lissa, D.3    Vacchelli, E.4    Malik, S.A.5
  • 47
    • 1542605222 scopus 로고    scopus 로고
    • Flavonoids: Antioxidants or signalling molecules?
    • DOI 10.1016/j.freeradbiomed.2004.01.001, PII S0891584904000334
    • Williams RJ, Spencer JP, Rice-Evans C (2004) Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36: 838-849. doi:10.1016/j. freeradbiomed.2004.01.001. PubMed: 15019969. (Pubitemid 38352901)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.7 , pp. 838-849
    • Williams, R.J.1    Spencer, J.P.E.2    Rice-Evans, C.3
  • 48
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • DOI 10.1016/j.fct.2007.05.015, PII S0278691507001780
    • Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM et al. (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45: 2179-2205. doi:10.1016/j.fct.2007.05.015. PubMed: 17698276. (Pubitemid 47451573)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.11 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 49
    • 33749239851 scopus 로고    scopus 로고
    • Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells
    • DOI 10.1080/10715760600794287, PII T43JR880P1157173, Polyphenols and Health
    • Shirai M, Kawai Y, Yamanishi R, Kinoshita T, Chuman H et al. (2006) Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells. Free Radic Res 40: 1047-1053. doi:10.1080/10715760600794287. PubMed: 17015249. (Pubitemid 44480545)
    • (2006) Free Radical Research , vol.40 , Issue.10 , pp. 1047-1053
    • Shirai, M.1    Kawai, Y.2    Yamanishi, R.3    Kinoshita, T.4    Chuman, H.5    Terao, J.6
  • 50
    • 8444233189 scopus 로고    scopus 로고
    • Flavonoid metabolites in human plasma and urine after the consumption of red onions: Analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection
    • DOI 10.1016/j.chroma.2004.08.117, PII S0021967304014761, Mass Spectrometry: Innovation and Application. Part III
    • Mullen W, Boitier A, Stewart AJ, Crozier A (2004) Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection. J Chromatogr A 1058: 163-168. doi:10.1016/j.chroma. 2004.08.117. PubMed: 15595664. (Pubitemid 39487216)
    • (2004) Journal of Chromatography A , vol.1058 , Issue.1-2 , pp. 163-168
    • Mullen, W.1    Boitier, A.2    Stewart, A.J.3    Crozier, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.