Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6

Molecular Vision

Volumn 13, Issue , 2007, Pages 57-65

  Spence, Jason R ^a,b   Madhavan, Mayur ^a,b   Aycinena, Juan Carlos ^a   Del Rio Tsonis, Katia ^a  

^a MIAMI UNIVERSITY   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; MATRIX PROTEIN; MELANOSOMAL MATRIX PROTEIN 115; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MITF; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHICK EMBRYO; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROPHTHALMIA; NONHUMAN; OPTIC DISK CUP; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA DEVELOPMENT; SIGNAL TRANSDUCTION; TIME; TISSUE DIFFERENTIATION; TISSUE REGENERATION; UPREGULATION;

ANIMALS; AVIAN PROTEINS; CELL PROLIFERATION; CHICK EMBRYO; DOWN-REGULATION; EMBRYONIC DEVELOPMENT; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; EYE PROTEINS; FIBROBLAST GROWTH FACTOR 2; HOMEODOMAIN PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PAIRED BOX TRANSCRIPTION FACTORS; PIGMENT EPITHELIUM OF EYE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, FIBROBLAST GROWTH FACTOR; REGENERATION; REPRESSOR PROTEINS; RETINA; RETROVIRIDAE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33846521209     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Spence JR, Madhavan M, Ewing JD, Jones DK, Lehman BM, Del Rio-Tsonis K. The hedgehog pathway is a modulator of retina regeneration. Development 2004; 131:4607-21.
2. Del Rio-Tsonis K, Tsonis PA. Eye regeneration at the molecular age. Dev Dyn 2003; 226:211-24.
3. Tsonis PA, Del Rio-Tsonis K. Lens and retina regeneration: transdifferentiation, stem cells and clinical applications. Exp Eye Res 2004; 78:161-72.
4. Coulombre JL, Coulombre AJ. Regeneration of neural retina from the pigmented epithelium in the chick embryo. Dev Biol 1965; 12:79-92.
5. Park CM, Hollenberg MJ. Basic fibroblast growth factor induces retinal regeneration in vivo. Dev Biol 1989; 134:201-5.
6. Park CM, Hollenberg MJ. Induction of retinal regeneration in vivo by growth factors. Dev Biol 1991; 148:322-33.
7. Zhao S, Hung FC, Colvin JS, White A, Dai W, Lovicu FJ, Ornitz DM, Overbeek PA. Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development 2001; 128:5051-60.
8. Nguyen M, Arnheiter H. Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development 2000; 127:3581-91.
9. Vogel-Hopker A, Momose T, Rohrer H, Yasuda K, Ishihara L, Rapaport DH. Multiple functions of fibroblast growth factor-8 (FGF-8) in chick eye development. Mech Dev 2000; 94:25-36.
10. Galy A, Neron B, Planque N, Saule S, Eychene A. Activated MAPK/Erk kinase (MEK-1) induces transdifferentiation of pigmented epithelium into neural retina. Dev Biol 2002; 248:251-64.
11. Hill RE, Favor J, Hogan BL, Ton CC, Saunders GF, Hanson IM, Prosser J, Jordan T, Hastie ND, van Heyningen V. Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 1991; 354:522-5. Erratum in: Nature. 1992; 355(6362): 750.
12. Burmeister M, Novak J, Liang MY, Basu S, Ploder L, Hawes NL, Vidgen D, Hoover F, Goldman D, Kalnins VI, Roderick TH, Taylor BA, Hankin MH, McInnes RR. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 1996; 12:376-84.
13. Barabino SM, Spada F, Cotelli F, Boncinelli E. Inactivation of the zebrafish homologue of Chx10 by antisense oligonucleotides causes eye malformations similar to the ocular retardation phenotype. Mech Dev 1997; 63:133-43.
14. Ferda Percin E, Ploder LA, Yu JJ, Arici K, Horsford DJ, Rutherford A, Bapat B, Cox DW, Duncan AM, Kalnins VI, Kocak-Altintas A, Sowden JC, Traboulsi E, Sarfarazi M, McInnes RR. Human microphthalmia associated with mutations in the retinal homeobox gene CHX10. Nat Genet 2000; 25:397-401.
15. Ashery-Padan R, Gruss P. Pax6 lights-up the way for eye development. Curr Opin Cell Biol 2001; 13:706-14.
16. Marquardt T, Ashery-Padan R, Andrejewski N, Scardigli R, Guillemot F, Gruss P. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 2001; 105:43-55.
17. Horsford DJ, Nguyen MT, Sellar GC, Kothary R, Arnheiter H, McInnes RR. Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development 2005; 132:177-87.
18. Mochii M, Ono T, Matsubara Y, Eguchi G. Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in the Mitf gene. Dev Biol 1998; 196:145-59.
19. Scholtz CL, Chan KK. Complicated colobomatous microphthalmia in the microphthalmic (mi/mi) mouse. Development 1987; 99:501-8.
20. Bumsted KM, Barnstable CJ. Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse. Invest Ophthalmol Vis Sci 2000; 41:903-8.
21. Mochii M, Mazaki Y, Mizuno N, Hayashi H, Eguchi G. Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell. Dev Biol 1998; 193:47-62.
22. Planque N, Leconte L, Coquelle FM, Martin P, Saule S. Specific Pax-6/ microphthalmia transcription factor interactions involve their DNA-binding domains and inhibit transcriptional properties of both proteins. J Biol Chem 2001; 276:29330-7.
23. Azuma N, Tadokoro K, Asaka A, Yamada M, Yamaguchi Y, Handa H, Matsushima S, Watanabe T, Kida Y, Ogura T, Torii M, Shimamura K, Nakafuku M. Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor. Hum Mol Genet 2005; 14:1059-68.
24. Planque N, Raposo G, Leconte L, Anezo O, Martin P, Saule S. Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells. J Biol Chem 2004; 279:41911-7.
25. Kumasaka M, Sato S, Yajima I, Goding CR, Yamamoto H. Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf. Dev Dyn 2005; 234:523-34.
26. Mochii M, Agata K, Eguchi G. Complete sequence and expression of a cDNA encoding a chicken 115-kDa melanosomal matrix protein. Pigment Cell Res 1991; 4:41-7.
27. Fuhrmann S, Levine EM, Reh TA. Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick. Development 2000; 127:4599-609.
28. Iwakiri R, Kobayashi K, Okinami S, Kobayashi H. Suppression of Mitf by small interfering RNA induces dedifferentiation of chick embryonic retinal pigment epithelium. Exp Eye Res 2005; 81:15-21.
29. Pittack C, Grunwald GB, Reh TA. Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos. Development 1997; 124:805-16.
30. Desire L, Head MW, Fayein NA, Courtois Y, Jeanny JC. Suppression of fibroblast growth factor 2 expression by antisense oligonucleotides inhibits embryonic chick neural retina cell differentiation and survival in vivo. Dev Dyn 1998; 212:63-74.
31. Martinez-Morales JR, Dolez V, Rodrigo I, Zaccarini R, Leconte L, Bovolenta P, Saule S. OTX2 activates the molecular network underlying retina pigment epithelium differentiation. J Biol Chem 2003; 278:21721-31.
32. Madhavan M, Haynes TL, Frisch NC, Call MK, Minich CM, Tsonis PA, Del Rio-Tsonis K. The role of Pax-6 in lens regeneration. Proc Natl Acad Sci U S A 2006; 103:14848-53.